Product image of Infester (Tioconazole) supplied by GNH India

Infester

Active Ingredient:
Tioconazole
Origin:
EU

Infester (Tioconazole)

Tioconazole, the active ingredient in Infester, is an imidazole antifungal presented as a topical formulation for skin use. Approved in the European Union, it treats superficial fungal infections such as athlete’s foot, jock itch, ringworm and cutaneous candidiasis in both adults and children.

GNH India supplies Infester as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide. The company adheres to stringent quality standards and provides regulatory documentation for global distribution.

Manufacturer / TM Owner

Target Pharma Single Member Private Ltd

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Indications & Clinical Uses

Tioconazole is an imidazole antifungal that targets superficial dermatophyte and yeast infections of the skin.

  • Tinea pedis: alleviates itching and clears fungal infection on the feet.
  • Tinea cruris: reduces redness and eliminates fungal growth in the groin area.
  • Tinea corporis: treats ring‑shaped lesions on the body by eradicating the causative fungus.
  • Cutaneous candidiasis: resolves yeast‑related skin eruptions and prevents recurrence.

How It Works

  • Tioconazole inhibits the fungal enzyme lanosterol 14α‑demethylase, a key component of the ergosterol biosynthesis pathway. By blocking this enzyme, the drug prevents formation of ergosterol, an essential sterol for fungal cell membranes, leading to increased membrane permeability and ultimately fungal cell death.

Side Effects

Topical application of Tioconazole may be associated with local and systemic adverse reactions.

Common Side Effects

  • Mild burning or stinging at the application site
  • Transient itching
  • Redness or erythema
  • Dryness or peeling of the skin

Serious or Rare Side Effects

  • Severe allergic dermatitis
  • Contact urticaria
  • Systemic hypersensitivity reactions

Precautions & Warnings

When using Infester, consider the following precautions to ensure safe and effective therapy.

  • Application area: limit use to affected skin only and avoid mucous membranes.
  • Duration of therapy: follow prescriber’s recommended treatment length; prolonged use may increase irritation.
  • Concomitant skin conditions: avoid use on compromised skin, open wounds, or eczematous lesions without medical advice.
  • Pediatric use: safety in children under two years has not been established; use only if prescribed.
  • Pregnancy and lactation: consult a healthcare professional before use during pregnancy or breastfeeding.
  • Store at below 25°C: keep the product in the original container, protect from moisture and direct sunlight.

Avoid Interactions

Tioconazole may interact with other topical agents or systemic medications that affect fungal metabolism.

Major Interactions (Avoid)

  • Concurrent use of other topical antifungal creams: may increase risk of local irritation.
  • Systemic azole antifungals (e.g., fluconazole, itraconazole): can lead to additive systemic exposure if large skin areas are treated.

Moderate Interactions (Monitor Closely)

  • Corticosteroid creams applied to the same area: may reduce antifungal efficacy.
  • Occlusive dressings over treated skin: can enhance absorption and increase irritation.
  • Products containing alcohol or harsh solvents: may exacerbate skin dryness.

Frequently Asked Questions

Infester is indicated for the topical treatment of superficial fungal infections of the skin, including athlete’s foot (tinea pedis), jock itch (tinea cruris), ringworm (tinea corporis) and cutaneous candidiasis caused by yeast species.

Tioconazole blocks the fungal enzyme lanosterol 14α‑demethylase, which is essential for producing ergosterol, a key component of the fungal cell membrane. Inhibiting this pathway disrupts membrane integrity, leading to fungal cell death.

The specific dose and frequency are determined by the prescribing clinician based on the infection type, severity, and patient factors. Typically, a thin layer is applied to the affected area once or twice daily for the prescribed duration.

Safety data for Tioconazole in pregnancy and lactation are limited. Women who are pregnant, planning pregnancy, or breastfeeding should discuss potential risks and benefits with their healthcare provider before using Infester.

To order Infester, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any required import documentation.

Both Tioconazole (Infester) and clotrimazole belong to the imidazole class and share a similar mechanism of inhibiting ergosterol synthesis. Clinical studies suggest comparable efficacy for common dermatophyte infections, while formulation differences may affect patient preference and tolerability.

Infester should be stored at temperatures below 25 °C, in its original packaging, protected from moisture and direct sunlight. Do not freeze the product, and keep the container tightly closed when not in use.

Clean and dry the affected skin area before use. Apply a thin, even layer of Infester to the lesion and a small margin of surrounding skin, gently rubbing it in. Wash hands after application and avoid covering the treated area with occlusive dressings unless directed by a clinician.

Although rare, serious adverse reactions can include severe allergic dermatitis, contact urticaria and systemic hypersensitivity responses such as anaphylaxis. Patients should discontinue use and seek immediate medical attention if they experience widespread rash, swelling, or difficulty breathing.

Infester should be avoided in individuals with a known hypersensitivity to Tioconazole or any component of the formulation. It is also contraindicated on extensive broken skin, open wounds, or in patients for whom a prescriber determines that the risks outweigh the benefits.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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