Product image of Infilea (Clobetasol Propionate) supplied by GNH India

Infilea

Active Ingredient:
Clobetasol Propionate
Origin:
EU

Infilea (Clobetasol Propionate)

Clobetasol Propionate, the active ingredient in Infilea, is a potent topical corticosteroid presented as a skin‑directed formulation for topical use. It is employed to manage inflammatory dermatoses such as psoriasis, eczema, dermatitis and lichen planus in adult patients.
GNH India supplies Infilea as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Egis Pharmaceuticals Plc

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Indications & Clinical Uses

Clobetasol Propionate is a high‑potency corticosteroid used to treat inflammatory skin disorders.

  • Psoriasis: reduces plaque thickness and scaling by suppressing inflammation.
  • Eczema: alleviates itching and erythema through local immunosuppression.
  • Dermatitis: diminishes redness and swelling associated with contact or atopic dermatitis.
  • Lichen planus: controls lesions by decreasing immune‑mediated skin damage.

How It Works

  • Clobetasol Propionate binds to intracellular glucocorticoid receptors, forming a complex that translocates to the nucleus and modulates gene transcription. This interaction up‑regulates anti‑inflammatory proteins and down‑regulates pro‑inflammatory cytokines, leading to reduced leukocyte infiltration, vasoconstriction, and suppression of immune responses in the skin.

Side Effects

Topical application of clobetasol can produce local and systemic reactions, especially with prolonged use.

Common Side Effects

  • Skin irritation or burning sensation at the application site.
  • Dryness or peeling of the treated skin.
  • Mild erythema or folliculitis.
  • Pruritus after withdrawal.
  • Telangiectasia in the treated area.

Serious or Rare Side Effects

  • Atrophy of the epidermis or dermis leading to thinning skin.
  • Secondary bacterial, fungal or viral skin infections.
  • Hypopigmentation or depigmentation.
  • Systemic adrenal suppression with extensive use.
  • Allergic contact dermatitis to the formulation.

Precautions & Warnings

Clobetasol Propionate should be used according to clinical guidelines and prescriber instructions.

  • Duration of therapy: limit use to the shortest effective period to avoid skin atrophy.
  • Application area: avoid large surface areas, especially in children.
  • Occlusion: do not cover treated skin with airtight dressings unless directed.
  • Pre‑existing infections: treat bacterial, fungal or viral skin infections before initiating therapy.
  • Systemic absorption: monitor for signs of adrenal suppression with extensive or prolonged use.
  • Store at room temperature: keep in original container, protect from moisture and direct sunlight.

Avoid Interactions

Clobetasol Propionate may interact with other agents that affect skin integrity or systemic corticosteroid levels. Major Interactions (Avoid):\n- Systemic corticosteroids: concurrent use can increase risk of systemic adrenal suppression.

  • Potent immunosuppressants (e.g., tacrolimus ointment): may enhance local immunosuppression and infection risk.

Moderate Interactions (Monitor Closely)

  • Antifungal or antibacterial topicals: monitor for reduced efficacy or increased irritation.
  • Skin‑lightening agents (hydroquinone): may increase risk of hypopigmentation.
  • Occlusive dressings: may raise systemic absorption, requiring observation.

Frequently Asked Questions

Infilea contains clobetasol propionate, a high‑potency corticosteroid indicated for inflammatory skin disorders such as psoriasis, eczema, dermatitis and lichen planus. It works by reducing inflammation, itching and scaling when applied to the affected skin areas.

Clobetasol propionate binds to glucocorticoid receptors inside skin cells, altering gene expression to increase anti‑inflammatory proteins and suppress pro‑inflammatory cytokines. This results in reduced leukocyte migration, vasoconstriction, and overall suppression of the local immune response.

The dosage of Infilea is determined by the prescribing clinician based on the severity of the skin condition, the area to be treated and patient factors. The prescriber will specify the amount to apply, frequency and duration of therapy.

The safety of clobetasol propionate in pregnancy and lactation has not been definitively established. It should be used only if the potential benefit justifies any potential risk to the fetus or infant, and under the guidance of a qualified healthcare professional.

To place an order, submit an enquiry on the Infilea product page at gnhindia.com, indicating the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Infilea (clobetasol propionate) is classified as a super‑potent (Class I) topical corticosteroid, offering stronger anti‑inflammatory effects than mid‑potency agents such as betamethasone dipropionate. It is typically reserved for resistant or severe dermatoses where lower‑potency steroids have been insufficient.

Store Infilea at room temperature, below 25 °C, in its original packaging. Keep the product away from moisture, direct sunlight and extreme heat to maintain its stability and potency.

Infilea is applied topically to clean, dry skin. A thin layer should be spread over the affected area, gently massaged in, and washed off after the prescribed duration if instructed. Hands should be washed after application to avoid inadvertent contact with other skin surfaces.

Serious risks include skin atrophy, secondary infections, systemic adrenal suppression, and rare allergic reactions. Patients should be monitored for signs of thinning skin, unusual bruising, fatigue, or systemic symptoms, especially with prolonged or extensive use.

Infilea should be avoided in individuals with known hypersensitivity to clobetasol propionate or any formulation excipients, in untreated skin infections, and in children under 12 years for large‑area applications unless specifically directed by a specialist.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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