Infloc (Sodium Fusidate)

Infloc, a fusidic acid antibiotic, is applied to bacterial skin infections.

• Impetigo: reduces bacterial load and promotes healing of superficial skin lesions.
• Folliculitis: eliminates the causative Staphylococcus organisms and alleviates inflammation.
• Secondary bacterial infections of dermatitis: controls bacterial overgrowth and prevents worsening of dermatitis lesions.

• Sodium fusidate inhibits bacterial protein synthesis by binding to elongation factor G (EF‑G) on the ribosome, preventing its turnover and blocking the translocation step of peptide chain elongation, which halts bacterial growth.

Adverse reactions may occur with topical use of Infloc.

Common Side Effects

• Skin irritation: mild redness or discomfort at the application site.
• Itching: localized pruritus.
• Burning sensation: transient warmth or stinging.
• Dryness: flaking or scaling of the skin.
• Rash: erythematous macular eruption.
• Contact dermatitis: localized allergic response.

Serious or Rare Side Effects

• Allergic reaction: swelling, hives, or angioedema.
• Stevens‑Johnson syndrome: severe mucocutaneous necrosis.
• Toxic epidermal necrolysis: extensive skin detachment.
• Severe dermatitis: widespread inflammation.
• Systemic hypersensitivity: fever, malaise, or organ involvement.
• Anaphylaxis: rapid onset of life‑threatening symptoms.

When using Infloc, consider the following safety measures.

• Allergy assessment: verify no known hypersensitivity to fusidic acid or formulation components.
• Indication limitation: apply only to the specified skin infections.
• Surface area restriction: avoid extensive application over large body areas.
• Monitoring: watch for signs of worsening infection or systemic absorption, especially on compromised skin.
• Avoid ocular use: do not apply to eyes or mucous membranes.
• Store at room temperature: keep in the original packaging, protect from moisture and light.

Potential drug interactions should be evaluated before prescribing Infloc.

Major Interactions (Avoid)

• Concurrent systemic fusidic acid: may increase systemic exposure.
• Topical corticosteroids: can mask infection signs and reduce efficacy.
• Other topical antibiotics: possible antagonistic effects.

Moderate Interactions (Monitor Closely)

• Silver‑containing dressings: may affect drug absorption.
• Moisturizers or emollients: could dilute the concentration.
• Phototherapy: may increase photosensitivity risk.