Product image of Infutraze (Zinc Chloride, Potassium Iodide, Sodium Selenite, Copper Chloride Dihydrate, Manganese Chloride Tetr) supplied by GNH India

Infutraze

Active Ingredient:
Zinc Chloride, Potassium Iodide, Sodium Selenite, Copper Chloride Dihydrate, Manganese Chloride Tetr
Origin:
EU

Infutraze (Zinc Chloride, Potassium Iodide, Sodium Selenite, Copper Chloride Dihydrate, Manganese Chloride Tetr)

Zinc chloride, potassium iodide, sodium selenite, copper chloride dihydrate, and manganese chloride tetrahydrate, the active ingredients in Infutraze, are trace element supplements presented as an intravenous solution for parenteral nutrition use. They help correct trace element deficiencies in patients receiving total parenteral nutrition or who have increased metabolic demands.

GNH India supplies Infutraze as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals worldwide. The company adheres to stringent quality standards and provides regulatory‑approved batches to clinical nutrition teams across continents.

Manufacturer / TM Owner

Fresenius Kabi Ab

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Indications & Clinical Uses

Infutraze is used to address trace element deficiencies in patients receiving parenteral nutrition.

  • Trace element deficiency: restores essential zinc, iodine, selenium, copper, and manganese levels to support enzymatic activity.
  • Total parenteral nutrition (TPN): provides a balanced trace element profile to complement macronutrient solutions.
  • Post‑operative recovery: helps prevent deficiency‑related complications in patients unable to take oral nutrition.
  • Critical illness: supports metabolic processes in intensive care patients receiving intravenous feeding.

How It Works

  • Infutraze delivers a combination of essential trace elements directly into the bloodstream, bypassing gastrointestinal absorption. Zinc, copper, manganese, iodine, and selenium serve as cofactors for numerous enzymes involved in antioxidant defense, thyroid hormone synthesis, and cellular metabolism. By supplying these micronutrients intravenously, the formulation ensures immediate bioavailability, facilitating enzymatic reactions and maintaining physiological homeostasis in patients dependent on parenteral nutrition.

Side Effects

Infutraze may be associated with infusion‑related reactions and, rarely, systemic toxicities.

Common Side Effects

  • Infusion site erythema: redness at the injection site.
  • Mild nausea: transient feeling of queasiness.
  • Headache: low‑grade headache during or after infusion.

Serious or Rare Side Effects

  • Anaphylactic reaction: severe allergic response requiring immediate medical intervention.
  • Electrolyte imbalance: abnormal serum copper or zinc levels causing organ dysfunction.
  • Selenium toxicity: respiratory distress or gastrointestinal upset in cases of excess.

Precautions & Warnings

When using Infutraze, clinicians should observe several precautions to minimize risks.

  • Assess baseline trace element status: obtain serum levels before initiating therapy.
  • Monitor serum electrolytes: check zinc, copper, selenium, manganese, and iodine concentrations regularly.
  • Adjust dose in renal or hepatic impairment: reduce infusion rate if organ function is compromised.
  • Avoid concurrent high‑dose trace element supplements: prevent cumulative toxicity.
  • Observe for infusion reactions: be prepared to stop infusion and treat symptoms if they occur.
  • Store at 2-8°C: keep refrigerated, protect from light, do not freeze or shake.

Avoid Interactions

Infutraze can interact with certain medications and supplements; awareness of these interactions helps ensure safe administration.

Major Interactions (Avoid)

  • High‑dose copper chelators (e.g., penicillamine): may markedly reduce copper availability.
  • Excessive iodine‑containing contrast agents: can lead to iodine overload and thyroid dysfunction.

Moderate Interactions (Monitor Closely)

  • Parenteral vitamin C solutions: may increase copper excretion and affect balance.
  • Anticoagulants (heparin): trace elements can potentiate bleeding risk; monitor coagulation parameters.
  • Other trace element preparations: combined use may cause cumulative toxicity; adjust dosing accordingly.

Frequently Asked Questions

Infutraze is an intravenous trace element supplement used to correct deficiencies of zinc, iodine, selenium, copper, and manganese in patients who receive total parenteral nutrition or have increased metabolic needs. It helps maintain enzymatic functions and supports overall metabolic health when oral intake is insufficient or not possible.

Each component acts as a cofactor for specific enzymes. Zinc supports DNA synthesis and immune function; iodine is essential for thyroid hormone production; selenium contributes to antioxidant enzymes; copper participates in iron metabolism and connective‑tissue formation; manganese is required for carbohydrate and lipid metabolism. Delivered intravenously, they become immediately available for cellular processes.

The dose of Infutraze is individualized by the prescribing clinician based on the patient’s serum trace‑element levels, the composition of the total parenteral nutrition regimen, and clinical condition. No fixed dosing schedule is provided; the healthcare professional calculates the appropriate amount to achieve target concentrations while avoiding excess.

Safety data for Infutraze in pregnancy and lactation are limited. It should only be used when the potential benefit to the mother outweighs any possible risk to the fetus or infant, and under close medical supervision. The prescriber must evaluate the clinical situation and consider alternative options if appropriate.

To order Infutraze, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies, and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details (including cold‑chain handling if needed), and any required import documentation.

Infutraze provides a balanced blend of five essential trace elements in a single intravenous formulation, which can simplify compounding compared with using separate single‑element solutions. Its composition aligns with European parenteral nutrition guidelines, offering comparable bioavailability while reducing the risk of incompatibility that may arise when mixing multiple individual additives.

Infutraze must be stored at 2‑8 °C, protected from light, and kept in its original container. Do not freeze or shake the solution. Before use, inspect the vial for particulate matter or discoloration and allow it to reach room temperature if required by the administration protocol.

Infutraze is administered intravenously, typically added to a compatible parenteral nutrition bag or infused as a separate line according to the prescriber’s instructions. The infusion rate is adjusted based on the patient’s clinical status and laboratory monitoring to ensure safe delivery of the trace elements.

Serious risks include anaphylactic reactions, severe electrolyte imbalances (especially excess copper or zinc), and selenium toxicity, which can manifest as respiratory distress or gastrointestinal symptoms. Prompt recognition and management of these events are essential, and regular monitoring of serum trace‑element levels helps mitigate these risks.

Infutraze should be avoided in patients with known hypersensitivity to any of its components, those with severe copper or zinc overload, and individuals receiving high‑dose concurrent trace‑element supplements that could cause cumulative toxicity. Clinical judgment is required for patients with significant hepatic or renal impairment.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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