Product image of Ingrezza (Valbenazine ) 40mg Capsule supplied by GNH India

Ingrezza

Active Ingredient:
Valbenazine
Form:
Capsule
Brand:
Ingrezza
Origin:
USA

Ingrezza (Valbenazine Capsule) 40mg

Valbenazine, the active ingredient in Ingrezza, is a VMAT2 inhibitor presented as a 40mg capsule for oral use. It is used to treat tardive dyskinesia and chorea associated with Huntington’s disease.

GNH India supplies Ingrezza as a licensed, GDP-compliant international pharmaceutical supplier serving hospitals, pharmacies, and clinics worldwide.

Strength

40mg

Pack Size

30s

Storage

Ambient

Manufacturer / TM Owner

Neurocrine

1
Pack/s
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Indications & Clinical Uses

Ingrezza is used to manage movement disorders.

  • Tardive dyskinesia: Reduces involuntary movements of the face, tongue, or other body parts.
  • Huntington’s chorea: Decreases involuntary movements caused by Huntington’s disease.

How It Works

  • Valbenazine works by reversibly inhibiting the vesicular monoamine transporter 2 (VMAT2), which decreases the release of dopamine and other monoamines in the brain. This action helps to reduce the symptoms of movement disorders.

Side Effects

Ingrezza may cause various side effects, ranging from mild to severe.

Common Side Effects

  • Drowsiness
  • Dizziness
  • Restlessness
  • Vomiting
  • Trouble swallowing
  • Loss of balance
  • Slowed movement
  • Shaking/tremors

Serious or Rare Side Effects

  • Depression and suicidal thoughts/attempts (especially in patients with Huntington’s disease)
  • Neuroleptic malignant syndrome (NMS)
  • Severe confusion
  • Severe tiredness
  • Muscle stiffness/pain/tenderness/weakness
  • Fever

Precautions & Warnings

Ingrezza should be used with caution and under medical supervision.

  • Depression monitoring: Regularly monitor for signs of depression or suicidal thoughts, especially in patients with Huntington’s disease.
  • MAO inhibitors: Avoid taking MAO inhibitors during treatment with Ingrezza.
  • Allergic reactions: Seek immediate medical attention if signs of a serious allergic reaction occur.
  • Kidney problems: Monitor for signs of kidney problems.
  • Storage: Store at room temperature away from light and moisture. Keep all medications away from children and pets.

Avoid Interactions

Ingrezza can interact with other medications, which may affect its efficacy or increase the risk of side effects.

Major Interactions (Avoid)

  • Monoamine oxidase inhibitors (MAOIs): Can increase the risk of MAOI side effects and make Ingrezza less effective.
  • Certain antiepileptics: Can make Ingrezza less effective.
  • Certain antifungal medications: Can increase the risk of side effects of Ingrezza.

Moderate Interactions (Monitor Closely)

  • Digoxin: Can increase the risk of side effects of digoxin.
  • Quinidine: Can increase the risk of side effects of Ingrezza.
  • Rifampin: Can make Ingrezza less effective.
  • Certain antibiotics: Can increase the risk of side effects of Ingrezza.
  • Certain antidepressants: Can increase the risk of side effects of Ingrezza.
  • Certain HIV medications: Can increase the risk of side effects of Ingrezza.

Frequently Asked Questions

Ingrezza is used to treat tardive dyskinesia, which involves involuntary movements of the face, tongue, or other body parts. It is also used to decrease the involuntary movements (chorea) caused by Huntington’s disease.

Valbenazine works by reversibly inhibiting the vesicular monoamine transporter 2 (VMAT2), which decreases the release of dopamine and other monoamines in the brain. This action helps to reduce the symptoms of movement disorders.

The dosage of Ingrezza is determined by your doctor based on your medical condition, response to treatment, and other medications you may be taking. Always follow your doctor's instructions for the correct dosage.

The safety of Ingrezza during pregnancy or breastfeeding is not well established. It is important to discuss the potential risks and benefits with your doctor if you are pregnant, planning to become pregnant, or breastfeeding.

To order Ingrezza from GNH India, submit an enquiry on the product page at gnhindia.com with the required quantity. GNH India supplies hospitals, pharmacies, and procurement teams across international markets and will ask the buyer to confirm trade or institutional credentials. The team will then reply with pricing, availability, shipping, and the import paperwork.

Ingrezza is a VMAT2 inhibitor specifically approved for tardive dyskinesia and Huntington’s chorea. It works by decreasing the release of dopamine in the brain. Other treatments may include anticholinergics or other medications that target different pathways. The choice of treatment depends on individual patient needs and response.

Ingrezza should be stored at room temperature away from light and moisture. Keep all medications away from children and pets. Do not store in the bathroom. Properly discard this product when it is expired or no longer needed.

Ingrezza is taken orally, usually once daily, with or without food. The capsules should be swallowed whole with a glass of water. If you have trouble swallowing, consult your doctor for alternative administration methods.

The most serious risks to watch for with Ingrezza include depression and suicidal thoughts/attempts, especially in patients with Huntington’s disease. Other serious risks include neuroleptic malignant syndrome (NMS), severe confusion, severe tiredness, muscle stiffness/pain/tenderness/weakness, and fever.

Ingrezza should not be used by individuals who are allergic to valbenazine or any of its ingredients. It should be used with caution in patients with a history of depression or suicidal thoughts, especially those with Huntington’s disease. Always consult your doctor before starting Ingrezza.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

References

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