Product image of Inhanimon (Nitric Oxide) supplied by GNH India

Inhanimon

Active Ingredient:
Nitric Oxide
Origin:
EU

Inhanimon (Nitric Oxide)

Nitric Oxide, the active ingredient in Inhanimon, is a vasodilator presented as a gas for inhalation use. It relaxes smooth muscle in the pulmonary vasculature and improves ventilation‑perfusion matching in patients with respiratory and cardiovascular conditions.

GNH India supplies Inhanimon as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, transplant centres, oncology centres, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Siad Hungary Gázokat Forgalmazó És Termelő Kft.

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Indications & Clinical Uses

Inhanimon delivers inhaled nitric oxide, targeting the pulmonary vasculature and respiratory pathways.

  • Pulmonary arterial hypertension: reduces pulmonary artery pressure and improves oxygenation.
  • Neonatal persistent pulmonary hypertension: facilitates transition to normal pulmonary circulation.
  • Acute respiratory distress syndrome (ARDS): enhances ventilation‑perfusion matching and oxygen delivery.
  • Post‑cardiac surgery pulmonary hypertension: supports hemodynamic stability.
  • Severe hypoxic respiratory failure: provides temporary oxygenation support.

How It Works

  • Inhaled nitric oxide diffuses across the alveolar‑capillary membrane and activates soluble guanylate cyclase in vascular smooth‑muscle cells. This raises cyclic GMP levels, causing selective relaxation of pulmonary smooth muscle and vasodilation of ventilated lung regions, thereby improving ventilation‑perfusion matching without causing systemic hypotension.

Side Effects

Inhaled nitric oxide may be associated with a range of adverse reactions, varying in frequency and severity.

Common Side Effects

  • Headache: mild to moderate headache due to cerebral vasodilation.
  • Flushing: transient warmth and redness of the skin.
  • Nausea: occasional feeling of queasiness.
  • Dizziness: light‑headed sensation during therapy.
  • Cough: irritation of airways from gas delivery.

Serious or Rare Side Effects

  • Methemoglobinemia: elevated methemoglobin levels reducing oxygen transport.
  • Nitrogen dioxide formation: inhalation of NO₂ leading to pulmonary irritation.
  • Hypotension: systemic blood pressure drop if high doses are absorbed.
  • Bleeding: increased risk of hemorrhage in patients on anticoagulants.

Precautions & Warnings

When prescribing inhaled nitric oxide, clinicians should consider several safety measures.

  • Dose titration: adjust concentration based on patient response and monitoring.
  • Monitoring: regularly assess methemoglobin and nitrogen dioxide levels during therapy.
  • Contraindications: avoid in patients with known hypersensitivity to nitric oxide.
  • Drug interactions: review concurrent use of phosphodiesterase inhibitors and anticoagulants.
  • Pregnancy and lactation: use only if benefits outweigh potential risks.
  • Store at room temperature: keep cylinders in original packaging, protect from heat and direct sunlight.

Avoid Interactions

Inhaled nitric oxide can interact with other agents that affect the nitric oxide pathway or blood coagulation.

Major Interactions (Avoid)

  • Sildenafil or other PDE‑5 inhibitors: additive vasodilatory effect may cause severe hypotension.
  • Methylene blue: can reverse nitric oxide effects and precipitate methemoglobinemia.
  • High‑dose inhaled NO with systemic vasodilators: risk of systemic hypotension.

Moderate Interactions (Monitor Closely)

  • Anticoagulants (warfarin, heparin): increased bleeding risk when methemoglobinemia occurs.
  • Bronchodilators: may enhance airway reactivity.
  • Ventilator settings: adjust to prevent accumulation of nitrogen dioxide.

Frequently Asked Questions

Inhanimon is an inhaled form of nitric oxide used to manage pulmonary arterial hypertension, neonatal persistent pulmonary hypertension, and acute respiratory distress syndrome. By selectively dilating pulmonary vessels, it improves oxygenation and reduces the workload on the right side of the heart in these conditions.

Nitric oxide released from Inhanimon activates soluble guanylate cyclase in pulmonary smooth‑muscle cells, increasing cyclic GMP. This biochemical cascade relaxes the smooth muscle, causing selective vasodilation of well‑ventilated lung areas, which enhances ventilation‑perfusion matching and raises arterial oxygen levels.

The dose of Inhanimon is individualized and set by the prescribing clinician. Dosage is typically expressed as a concentration (parts per million) of inhaled gas and is titrated according to the patient’s response, oxygenation targets, and safety monitoring parameters.

Data on the use of inhaled nitric oxide in pregnancy and lactation are limited. It should be used only if the potential therapeutic benefit justifies any possible risk to the fetus or infant, and the decision must be made by the treating physician.

To order Inhanimon, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India supplies hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details (including any cold‑chain requirements) and import documentation.

Inhaled nitric oxide offers rapid, selective pulmonary vasodilation without significant systemic effects, unlike systemic agents such as sildenafil. Compared with inhaled prostacyclin analogues, nitric oxide has a shorter half‑life, allowing quick titration, but both classes require careful monitoring for methemoglobinemia and nitrogen dioxide formation.

Inhanimon cylinders should be stored at room temperature, kept in their original packaging, and protected from heat and direct sunlight. Ensure that cylinders are secured upright, and follow local regulations for handling compressed gases to prevent damage or accidental release.

Inhanimon is delivered via a specialized inhalation system that mixes the nitric oxide gas with the patient’s ventilator circuit or breathing apparatus. The clinician sets the desired concentration, and the device continuously monitors gas levels to maintain the prescribed therapeutic range.

The most serious adverse events include methemoglobinemia, which impairs oxygen transport, and the formation of nitrogen dioxide, a toxic pulmonary irritant. Systemic hypotension can also occur if excessive nitric oxide is absorbed. Continuous monitoring of methemoglobin and NO₂ levels is essential.

Inhanimon should be avoided in patients with known hypersensitivity to nitric oxide, those with severe anemia, or individuals receiving high‑dose systemic vasodilators that could precipitate profound hypotension. Caution is also advised for patients on anticoagulant therapy due to an increased bleeding risk.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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