Product image of Inhibace (Cilazapril) supplied by GNH India

Inhibace

Active Ingredient:
Cilazapril
Origin:
EU

Inhibace (Cilazapril)

Cilazapril, the active ingredient in Inhibace, is an angiotensin-converting enzyme (ACE) inhibitor presented as an oral tablet for oral use. It is prescribed to manage high blood pressure and to support treatment of heart failure in adult patients. It is indicated for patients requiring long‑term blood pressure control and for those with symptomatic heart failure, helping to reduce cardiovascular risk.

GNH India supplies Inhibace as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide, ensuring consistent quality and regulatory compliance across global markets.

Manufacturer / TM Owner

Cheplapharm Arzneimittel Gmbh

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Indications & Clinical Uses

Cilazapril is an ACE inhibitor used to treat conditions related to the renin‑angiotensin system.

  • Hypertension: lowers elevated blood pressure and reduces the risk of stroke.
  • Heart failure: improves symptoms, decreases hospitalisation and supports cardiac function.
  • High cardiovascular risk: helps lower the incidence of major cardiovascular events in patients with hypertension or heart failure.

How It Works

  • Cilazapril selectively inhibits angiotensin‑converting enzyme, preventing the conversion of angiotensin I to the potent vasoconstrictor angiotensin II. This results in vasodilation, reduced aldosterone secretion, decreased sodium and water retention, and ultimately lower systemic blood pressure.

Side Effects

Cilazapril may cause a range of adverse reactions. Most are mild and reversible, but rare events can be serious.

Common Side Effects

  • Cough: persistent dry cough.
  • Dizziness: especially on standing.
  • Headache.
  • Fatigue.

Serious or Rare Side Effects

  • Angioedema: swelling of face, lips, tongue or airway.
  • Severe hypotension: marked drop in blood pressure.
  • Acute renal failure: sudden decline in kidney function.

Precautions & Warnings

Before initiating Cilazapril, several safety considerations should be reviewed.

  • Blood pressure monitoring: ensure adequate control and avoid excessive hypotension.
  • Renal function assessment: check serum creatinine and eGFR regularly.
  • Serum potassium: monitor for hyperkalaemia, especially with potassium‑sparing agents.
  • Pregnancy: classified as Category D; avoid use during pregnancy.
  • History of angioedema: contraindicated in patients with prior ACE‑inhibitor‑induced angioedema.
  • Store at room temperature: keep in the original container, protect from moisture and direct sunlight.

Avoid Interactions

Cilazapril can interact with several drug classes, requiring attention to avoid adverse outcomes.

Major Interactions (Avoid)

  • Aliskiren: combined renin‑angiotensin blockade increases risk of renal impairment and hyperkalaemia.
  • Potassium‑sparing diuretics (e.g., spironolactone): may cause dangerous hyperkalaemia.
  • NSAIDs (e.g., ibuprofen): can blunt antihypertensive effect and worsen renal function.

Moderate Interactions (Monitor Closely)

  • Loop or thiazide diuretics: may enhance hypotensive response.
  • Lithium: ACE inhibition can raise lithium concentrations, risking toxicity.
  • Other antihypertensives (e.g., beta‑blockers): additive blood‑pressure‑lowering effect requires dose adjustment.

Frequently Asked Questions

Inhibace contains the ACE inhibitor cilazapril and is prescribed to lower high blood pressure (hypertension) and to treat chronic heart failure. By reducing vascular resistance and fluid overload, it helps improve cardiovascular outcomes in adult patients.

Cilazapril blocks the angiotensin‑converting enzyme, which stops the conversion of angiotensin I into angiotensin II. This reduces vasoconstriction, lowers aldosterone release, promotes sodium excretion, and ultimately leads to lower systemic blood pressure and decreased cardiac workload.

The dose of Inhibace is individualized by the prescribing clinician based on the patient’s blood‑pressure goals, renal function, and overall clinical status. Only a qualified healthcare professional should determine the appropriate regimen.

Cilazapril is classified as Pregnancy Category D, indicating evidence of risk to the fetus. It should be avoided during pregnancy, and breastfeeding is not recommended because the drug can be excreted in milk and may affect the infant.

To order Inhibace, submit an enquiry on the product page at gnhindia.com specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Inhibace (cilazapril) belongs to the same class as enalapril, lisinopril and ramipril. All share a similar mechanism of blocking ACE, but they differ in pharmacokinetic profiles, dosing frequency and potency. Cilazapril is often chosen for its once‑daily dosing and favorable tolerability in many patients.

Store Inhibace at room temperature, below 25 °C, in the original blister or bottle. Keep the product away from moisture, heat and direct sunlight to maintain its stability and potency.

Inhibace is supplied as an oral tablet that should be swallowed whole with a glass of water. It is usually taken once daily, but the exact timing and any food considerations are determined by the prescribing clinician.

The most serious adverse events include angioedema (swelling of the face, lips, tongue or airway), severe hypotension (especially after the first dose), and acute renal impairment. Patients should seek immediate medical attention if any of these symptoms occur.

Inhibace is contraindicated in patients with a known history of angioedema related to ACE‑inhibitor therapy, in pregnant women, and in individuals with severe renal artery stenosis or marked renal impairment. Caution is also advised for patients with hyperkalaemia or those taking potassium‑increasing drugs.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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