Product image of Inhixa (Enoxaparin Sodium) supplied by GNH India

Inhixa

Active Ingredient:
Enoxaparin Sodium
Origin:
EU

Inhixa (Enoxaparin Sodium)

Enoxaparin Sodium, the active ingredient in Inhixa, is a low molecular weight heparin presented as a sterile solution for subcutaneous administration. It is used to prevent and treat thromboembolic disorders in adult patients undergoing surgery, dialysis, or at risk of clot formation.

GNH India supplies Inhixa as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, transplant centres, oncology centres and pharmacies worldwide.

Manufacturer / TM Owner

Techdow Pharma Netherlands B.V.

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Indications & Clinical Uses

Enoxaparin Sodium is indicated for anticoagulation in several clinical settings related to venous thromboembolism and dialysis.

  • Deep vein thrombosis prophylaxis: prevents clot formation in postoperative orthopedic and general surgery patients.
  • Acute deep vein thrombosis treatment: facilitates clot resolution and reduces risk of embolization.
  • Pulmonary embolism treatment: provides anticoagulation to limit clot propagation.
  • Hemodialysis circuit anticoagulation: maintains patency of extracorporeal circuits during dialysis.
  • Acute coronary syndrome (unstable angina/NSTEMI): reduces risk of recurrent ischemic events.

How It Works

  • Enoxaparin Sodium binds to antithrombin III, accelerating its inhibition of activated factor Xa and, to a lesser extent, factor IIa (thrombin). This selective blockade reduces thrombin generation and fibrin clot formation, providing anticoagulant activity while preserving a more predictable pharmacokinetic profile than unfractionated heparin.

Side Effects

Enoxaparin Sodium may be associated with a range of adverse reactions, varying from mild to severe.

Common Side Effects

  • Injection site bruising or pain.
  • Minor bleeding such as gum or nosebleeds.
  • Elevated liver enzymes.
  • Nausea.
  • Mild thrombocytopenia.

Serious or Rare Side Effects

  • Major hemorrhage (intracranial or gastrointestinal).
  • Heparin‑induced thrombocytopenia (HIT).
  • Spinal or epidural hematoma.
  • Anaphylactic allergic reactions.
  • Severe thrombocytopenia with bleeding.
  • Rare liver failure.

Precautions & Warnings

When using Enoxaparin Sodium, clinicians should consider several safety measures.

  • Renal impairment: adjust dose or monitor anti‑Xa levels.
  • History of heparin‑induced thrombocytopenia: avoid use.
  • Recent surgery or trauma: assess bleeding risk.
  • Concomitant antiplatelet or anticoagulant therapy: increase monitoring.
  • Pregnancy and lactation: use only if benefit outweighs risk.
  • Store at 2-8°C: keep refrigerated, protect from light, do not freeze or shake.

Avoid Interactions

Enoxaparin Sodium can interact with other medicines, requiring careful management.

Major Interactions (Avoid)

  • Concurrent use with other anticoagulants (e.g., warfarin, direct oral anticoagulants) – high risk of severe bleeding.
  • Use with systemic thrombolytics – increased hemorrhagic risk.
  • Combination with non‑steroidal anti‑inflammatory drugs (NSAIDs) – potentiate bleeding.

Moderate Interactions (Monitor Closely)

  • Antiplatelet agents (e.g., clopidogrel, aspirin) – monitor for bleeding.
  • Selective serotonin reuptake inhibitors (SSRIs) – may increase bleeding tendency.
  • ACE inhibitors – possible additive effect on platelet function.
  • Certain antibiotics (e.g., vancomycin) – monitor renal function and anti‑Xa levels.

Frequently Asked Questions

Inhixa contains Enoxaparin Sodium, a low molecular weight heparin used to prevent and treat blood clots. It is commonly prescribed for deep vein thrombosis prophylaxis after surgery, treatment of acute DVT and pulmonary embolism, anticoagulation during hemodialysis, and as part of therapy for certain acute coronary syndromes.

Enoxaparin Sodium enhances the activity of antithrombin III, which selectively inhibits factor Xa and, to a lesser extent, factor IIa (thrombin). By blocking these key enzymes in the coagulation cascade, the drug reduces thrombin generation and prevents the formation and extension of fibrin clots.

The specific dose of Inhixa is determined by the prescribing clinician based on the patient’s indication, weight, renal function, and clinical condition. Dosing regimens vary for prophylaxis versus treatment, and the prescriber will set the appropriate amount and frequency.

The safety of Enoxaparin Sodium in pregnancy and lactation has not been definitively established. It may be used during pregnancy only when the potential benefit justifies the potential risk to the fetus, and breastfeeding decisions should be made in consultation with a healthcare professional.

To order Inhixa, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies, and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details (including cold‑chain where required) and necessary import documentation.

Inhixa (Enoxaparin) is a low molecular weight heparin offering more predictable anticoagulant effects, once‑daily or twice‑daily dosing, and a lower risk of heparin‑induced thrombocytopenia compared with unfractionated heparin. However, dose adjustments may be needed in severe renal impairment, and monitoring is less routine than with unfractionated heparin.

Inhixa should be stored at 2‑8 °C (refrigerated). Keep the vial in its original packaging, protect it from light, and do not freeze or shake the solution. If temporary storage at room temperature is unavoidable, limit exposure to no more than 24 hours and return to refrigeration promptly.

Inhixa is supplied as a sterile solution for subcutaneous injection. The injection is typically given in the abdomen or thigh, using aseptic technique. The prescriber determines the injection site, volume, and frequency based on the clinical indication and patient characteristics.

The most serious risks include major bleeding events such as intracranial or gastrointestinal hemorrhage, and heparin‑induced thrombocytopenia (HIT), which can paradoxically increase clot formation. Patients should be monitored for signs of unexpected bleeding, sudden drops in platelet count, or neurological changes.

Inhixa should be avoided in patients with a known hypersensitivity to enoxaparin or any component of the formulation, those with active major bleeding, or individuals with a history of heparin‑induced thrombocytopenia. Caution is also advised for patients with severe renal impairment unless dose adjustments are made.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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