Product image of Inj. Magnesii Sulfurici Polpharma (Magnesium Sulfate) supplied by GNH India

Inj. Magnesii Sulfurici Polpharma

Active Ingredient:
Magnesium Sulfate
Origin:
EU

Inj. Magnesii Sulfurici Polpharma (Magnesium Sulfate)

Magnesium sulfate, the active ingredient in Inj. Magnesii Sulfurici Polpharma, is an electrolyte presented as an injection for intramuscular and intravenous use. It treats magnesium deficiency and related conditions such as eclampsia, pre‑eclampsia, and certain cardiac arrhythmias.

GNH India supplies Inj. Magnesii Sulfurici Polpharma as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, transplant centres, oncology centres, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Zaklady Farmaceutyczne Polpharma S.A.

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Indications & Clinical Uses

Magnesium sulfate is used in the management of electrolyte disturbances and obstetric or cardiac conditions where magnesium deficiency or vasodilation is relevant.

  • Magnesium deficiency: restores normal serum magnesium concentrations.
  • Eclampsia: prevents seizures in pregnant women with severe hypertension.
  • Pre‑eclampsia: reduces progression to eclampsia and associated complications.
  • Torsades de pointes: stabilises cardiac repolarisation to terminate ventricular tachyarrhythmia.
  • Cardiac arrhythmias: corrects magnesium‑related rhythm disturbances.

How It Works

  • Magnesium sulfate dissociates to release Mg2+ ions that act as essential cofactors for numerous enzymatic reactions, stabilise cellular membranes, and modulate calcium influx. By increasing extracellular magnesium, it competes with calcium at voltage‑gated channels, producing vasodilation, reducing neuromuscular excitability, and normalising cardiac electrophysiology.

Side Effects

Adverse reactions may range from mild to severe and should be monitored during therapy.

Common Side Effects

  • Flushing or warmth at the injection site
  • Sweating or diaphoresis
  • Mild hypotension
  • Nausea or vomiting
  • Headache
  • Dizziness

Serious or Rare Side Effects

  • Severe hypotension or cardiovascular collapse
  • Life‑threatening arrhythmias
  • Respiratory depression
  • Hypermagnesemia with neuromuscular weakness
  • Anaphylactic or severe allergic reaction
  • Tissue necrosis or ulceration at the injection site

Precautions & Warnings

Magnesium sulfate requires careful assessment of patient conditions and monitoring during administration.

  • Renal impairment: monitor serum magnesium and adjust dose.
  • Cardiac disease: use cautiously; continuous ECG monitoring recommended.
  • Pregnancy: evaluate risk‑benefit, especially in obstetric emergencies.
  • Concomitant neuromuscular blockers: may potentiate muscle relaxation.
  • Incompatible solutions: avoid mixing with calcium‑containing fluids.
  • Store at 2-8°C: keep refrigerated, protect from light, do not freeze or shake.

Avoid Interactions

Magnesium sulfate can interact with several medicines, altering its efficacy or safety profile.

Major Interactions (Avoid)

  • Calcium gluconate: may precipitate insoluble salts.
  • Aminoglycoside antibiotics: increased risk of neuromuscular blockade.
  • Potassium‑sparing diuretics: heightened chance of hypermagnesemia.

Moderate Interactions (Monitor Closely)

  • ACE inhibitors: additive hypotensive effect.
  • Beta‑blockers: possible enhanced cardiovascular depression.
  • Loop diuretics: may increase renal magnesium loss, requiring monitoring.

Frequently Asked Questions

Inj. Magnesii Sulfurici Polpharma contains magnesium sulfate and is used to correct magnesium deficiency, manage eclampsia and pre‑eclampsia in pregnancy, treat certain cardiac arrhythmias such as torsades de pointes, and provide seizure prophylaxis in high‑risk situations.

Magnesium sulfate releases magnesium ions that serve as cofactors for many enzymes, stabilise cell membranes, and antagonise calcium at voltage‑gated channels. This results in vasodilation, reduced neuromuscular excitability, and normalisation of cardiac electrical activity, helping to correct deficiencies and prevent seizures.

The specific dose of Inj. Magnesii Sulfurici Polpharma is determined by the prescribing clinician based on the patient’s condition, weight, renal function and therapeutic goals. Healthcare professionals calculate the appropriate amount and administration rate for each individual case.

Magnesium sulfate is commonly used in obstetric emergencies such as eclampsia, where the benefits outweigh potential risks. However, its use during pregnancy or lactation should be guided by a qualified healthcare provider who will assess maternal and fetal safety.

To place an order, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details (including cold‑chain where required) and necessary import documentation.

Inj. Magnesii Sulfurici Polpharma is an injectable magnesium sulfate formulation, offering rapid systemic availability compared with oral magnesium salts, which have slower absorption and variable bioavailability. It is preferred in acute settings such as severe deficiency, obstetric emergencies, or life‑threatening arrhythmias where immediate therapeutic levels are needed.

The product should be stored at 2‑8 °C, kept refrigerated, protected from light, and must not be frozen or shaken. Before use, inspect the vial for particulate matter or discoloration and allow it to reach room temperature if required for administration.

It is administered by a qualified healthcare professional via intramuscular or intravenous injection. The route, infusion rate and dilution (if any) are determined by the prescriber according to the clinical indication, patient condition and institutional protocols.

Serious risks include severe hypotension, life‑threatening arrhythmias, respiratory depression, hypermagnesemia leading to neuromuscular weakness or cardiac arrest, and rare anaphylactic reactions. Prompt monitoring of vital signs and serum magnesium levels helps mitigate these hazards.

Patients with known hypersensitivity to magnesium sulfate, severe renal impairment without appropriate monitoring, or those with existing hypermagnesemia should avoid this medication. Clinicians must also exercise caution in individuals with heart block, myasthenia gravis or concurrent use of potent neuromuscular blockers.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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