Product image of Injectafer (Ferric Carboxymaltose) supplied by GNH India

Injectafer

Active Ingredient:
Ferric Carboxymaltose
Origin:
EU

Injectafer (Ferric Carboxymaltose)

Ferric Carboxymaltose, the active ingredient in Injectafer, is an iron supplement presented as an injection solution for intravenous infusion. It treats iron deficiency anemia in adults, including patients with chronic kidney disease, inflammatory bowel disease, and postpartum women.

GNH India supplies Injectafer as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Vifor France

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Indications & Clinical Uses

Injectafer is used to correct iron deficiency anemia across several clinical contexts.

  • Iron deficiency anemia in adults: restores hemoglobin levels and improves functional capacity.
  • Iron deficiency anemia in chronic kidney disease: provides readily available iron for patients receiving dialysis or erythropoiesis‑stimulating agents.
  • Iron deficiency anemia in inflammatory bowel disease: compensates for malabsorption and chronic blood loss.
  • Iron deficiency anemia in postpartum women: rapidly replenishes iron stores after childbirth.

How It Works

  • Ferric carboxymaltose delivers a stable iron complex that is taken up by reticuloendothelial cells after intravenous infusion. Within these cells, the iron is released and bound to transferrin, becoming bioavailable for incorporation into hemoglobin and other iron‑dependent proteins, thereby correcting iron deficiency.

Side Effects

Injectafer may cause a range of adverse reactions, most of which are mild and transient.

Common Side Effects

  • Nausea or vomiting
  • Headache or dizziness
  • Injection‑site pain, erythema, or swelling
  • Transient hypotension or flushing
  • Metallic taste or dysgeusia
  • Mild fever or chills

Serious or Rare Side Effects

  • Anaphylactic or severe hypersensitivity reactions
  • Severe hypotension or shock
  • Acute respiratory distress syndrome (ARDS)
  • Hypophosphatemia leading to muscle weakness or bone pain
  • Cardiac arrhythmias in susceptible patients
  • Severe liver enzyme elevations

Precautions & Warnings

Before using Injectafer, clinicians should consider several safety measures.

  • Assess iron status: confirm iron deficiency before infusion.
  • Monitor during infusion: observe for hypersensitivity or cardiovascular changes.
  • Infusion rate: avoid rapid administration to reduce risk of hypotension.
  • Infection risk: use cautiously in patients with active infections.
  • Compatibility: do not mix with calcium‑containing solutions or other incompatible IV drugs.
  • Store at 2-8°C: keep refrigerated, protect from light, do not freeze or shake.

Avoid Interactions

Injectafer can interact with other medicines, requiring attention to avoid adverse outcomes.

Major Interactions (Avoid)

  • Concurrent high‑dose oral iron supplements: may reduce IV iron efficacy and increase gastrointestinal irritation.
  • Erythropoiesis‑stimulating agents (ESAs) without iron monitoring: risk of iron overload.

Moderate Interactions (Monitor Closely)

  • Tetracycline antibiotics: potential chelation reducing antibiotic absorption.
  • Antacids containing aluminum or magnesium: may affect iron complex stability.
  • Calcium channel blockers: monitor for additive hypotensive effects during infusion.

Frequently Asked Questions

Injectafer is an intravenous iron formulation indicated for the treatment of iron deficiency anemia in adults, including patients with chronic kidney disease, inflammatory bowel disease, and postpartum women. It provides a rapid source of bioavailable iron to restore hemoglobin levels and improve symptoms associated with anemia.

Ferric carboxymaltose delivers a stable iron complex that is taken up by reticuloendothelial cells after infusion. The iron is then released, bound to transferrin, and becomes available for incorporation into hemoglobin and other iron‑dependent proteins, effectively correcting iron deficiency.

The prescribed dose of Injectafer is individualized by the treating physician based on the patient’s iron deficit, body weight, and clinical condition. The healthcare provider determines the total iron requirement and the infusion schedule, ensuring safe and effective therapy.

Injectafer is classified as Pregnancy Category B, indicating that animal studies have not shown risk to the fetus and there are no adequate human studies. It may be used during pregnancy or lactation when the potential benefit justifies the potential risk, and the decision should be made by the prescribing clinician.

To order Injectafer, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India supplies hospitals, pharmacies and procurement teams worldwide, and will request trade or institutional credentials. The team then replies with pricing, availability, shipping details—including cold‑chain handling if needed—and the necessary import documentation.

Injectafer (ferric carboxymaltose) offers a high‑dose, single‑visit infusion option, allowing up to 1000 mg of iron to be administered in a short period. Compared with older iron sucrose formulations, it requires fewer infusion sessions and has a lower incidence of mild infusion‑related reactions, though both share similar serious hypersensitivity risks.

Injectafer must be stored refrigerated at 2–8 °C. It should be kept in its original container, protected from light, and must not be frozen or shaken. Prior to use, inspect the solution for particulate matter or discoloration and discard if any abnormalities are observed.

Injectafer is administered as an intravenous infusion by a qualified healthcare professional. The infusion rate is controlled according to the prescribed dose, typically over 15–30 minutes for doses up to 1000 mg. Monitoring of vital signs is recommended during and after the infusion.

The most serious risks include severe hypersensitivity reactions such as anaphylaxis, acute hypotension, and rare cases of hypophosphatemia that can lead to muscle weakness or bone pain. Prompt recognition and treatment of these events are essential, and patients should be observed closely during infusion.

Injectafer is contraindicated in patients with known hypersensitivity to ferric carboxymaltose or any of its excipients. It should also be avoided in individuals with active severe infections, uncontrolled hypertension, or a history of severe reactions to other intravenous iron products.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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