Product image of Injectafer (Iron) supplied by GNH India

Injectafer

Active Ingredient:
Iron
Origin:
EU

Injectafer (Iron)

Ferric carboxymaltose, the active ingredient in Injectafer, is an iron supplement presented as an injection solution for intravenous infusion use. It treats iron deficiency anemia in adults with chronic kidney disease, inflammatory bowel disease, postpartum hemorrhage, or those intolerant to oral iron therapy.

GNH India supplies Injectafer as a licensed, GDP-compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Vifor France

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Indications & Clinical Uses

Injectafer (ferric carboxymaltose) is used to correct iron deficiency anemia in adult patients where oral iron is ineffective or contraindicated.

  • Chronic kidney disease: restores hemoglobin levels and replenishes iron stores in adults with CKD‑related anemia.
  • Inflammatory bowel disease: improves anemia by providing intravenous iron when gastrointestinal absorption is impaired.
  • Postpartum hemorrhage: rapidly corrects iron loss after significant postpartum bleeding.
  • Oral iron intolerance: offers an alternative for patients who cannot tolerate oral iron preparations.

How It Works

  • Ferric carboxymaltose forms a stable iron‑carbohydrate complex that is taken up by macrophages of the reticuloendothelial system after intravenous administration. Within these cells, the complex releases elemental iron in a controlled manner, allowing incorporation into transferrin and subsequent delivery to the bone marrow for hemoglobin synthesis and to peripheral tissues for replenishment of iron stores.

Side Effects

Injectafer may be associated with a range of adverse reactions, varying from mild to severe.

Common Side Effects

  • Nausea: mild gastrointestinal discomfort.
  • Headache: transient cranial pain.
  • Injection site pain: local discomfort or erythema.
  • Hypotension: temporary drop in blood pressure during infusion.

Serious or Rare Side Effects

  • Anaphylactic reaction: severe allergic response requiring immediate medical attention.
  • Hypophosphatemia: marked decrease in serum phosphate levels.
  • Acute liver injury: elevated liver enzymes indicating hepatic stress.
  • Cardiovascular events: arrhythmias or myocardial ischemia in susceptible patients.

Precautions & Warnings

Before administering Injectafer, several safety considerations should be observed.

  • Assess iron status: confirm iron deficiency anemia and evaluate ferritin and TSAT levels.
  • Monitor during infusion: observe vital signs for hypotension or hypersensitivity.
  • Review cardiac history: patients with known cardiac disease may need closer monitoring.
  • Check renal function: adjust monitoring in severe renal impairment.
  • Avoid in known hypersensitivity: contraindicated in patients with previous severe reactions to ferric carboxymaltose or its components.
  • Store at 2-8°C: keep refrigerated, protect from light, do not freeze or shake.

Avoid Interactions

Injectafer can interact with certain medicines, influencing its safety or efficacy.

Major Interactions (Avoid)

  • Concurrent use of other IV iron products: may cause iron overload.
  • High-dose vitamin C supplements: increase iron absorption and risk of oxidative stress.

Moderate Interactions (Monitor Closely)

  • Erythropoiesis‑stimulating agents: may augment hemoglobin rise, requiring dose adjustment.
  • Antacids containing aluminum or magnesium: can affect iron complex stability.
  • Certain antibiotics (e.g., tetracyclines, fluoroquinolones): may chelate iron and reduce antibiotic effectiveness.

Frequently Asked Questions

Injectafer is indicated for the treatment of iron deficiency anemia in adult patients who have chronic kidney disease, inflammatory bowel disease, have experienced postpartum hemorrhage, or cannot tolerate oral iron preparations. It provides a rapid intravenous source of elemental iron to restore hemoglobin levels and replenish body iron stores.

Ferric carboxymaltose is a stable iron‑carbohydrate complex. After intravenous infusion, the complex is taken up by macrophages of the reticuloendothelial system, where iron is released in a controlled fashion. The released iron binds to transferrin, is delivered to the bone marrow for hemoglobin synthesis, and replenishes peripheral iron stores.

The dose of Injectafer is individualized by the prescribing clinician based on the patient’s iron deficit, body weight, and clinical condition. The healthcare professional determines the total elemental iron required and the infusion rate, following approved prescribing information and local guidelines.

The safety of Injectafer in pregnancy and lactation has not been definitively established. It should be used only if the potential benefit justifies any potential risk to the fetus or infant, and the decision must be made by a qualified healthcare provider after a careful risk‑benefit assessment.

To order Injectafer, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details (including cold‑chain logistics if needed) and any required import documentation.

Injectafer (ferric carboxymaltose) delivers a larger single‑dose of elemental iron compared with iron sucrose or iron gluconate, allowing fewer infusion sessions. Its stable complex reduces the risk of free‑iron reactions, but clinicians still monitor for hypersensitivity and hypophosphatemia. Choice of product depends on patient needs, dosing convenience, and safety profile.

Injectafer must be stored at 2‑8 °C (refrigerated). Keep the vial in its original packaging, protect it from light, and do not freeze or shake the solution. Before use, inspect for particulate matter or discoloration; discard any product that appears compromised.

Injectafer is given as an intravenous infusion. The recommended infusion time varies with the total dose but typically ranges from 15 to 30 minutes. Administration should be performed by qualified healthcare personnel in a setting where vital signs can be monitored and emergency equipment is available.

Serious adverse events include anaphylactic or severe hypersensitivity reactions, marked hypophosphatemia, acute liver injury, and cardiovascular complications such as arrhythmias or myocardial ischemia. Patients should be observed during and after infusion, and any signs of severe reaction require immediate medical intervention.

Injectafer is contraindicated in patients with known hypersensitivity to ferric carboxymaltose or any of its excipients. It should also be avoided in individuals who have experienced severe anaphylactic reactions to other intravenous iron products. Caution is advised in patients with active infections, uncontrolled cardiac disease, or severe hepatic impairment.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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