Product image of Injexate (Methotrexate) supplied by GNH India

Injexate

Active Ingredient:
Methotrexate
Origin:
EU

Injexate (Methotrexate)

Methotrexate, the active ingredient in Injexate, is an antimetabolite (folate antagonist) presented as an injectable solution for intramuscular, intravenous, or subcutaneous use. It is employed to treat autoimmune disorders and certain cancers in adult patients.

GNH India supplies Injexate as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, oncology centres and pharmacies worldwide. The company adheres to stringent quality standards and provides regulatory documentation for cross‑border distribution. Customers benefit from reliable logistics, temperature‑controlled shipping where required, and responsive technical support throughout the procurement process.

Manufacturer / TM Owner

Accord Healthcare Polska Sp. Z O.O.

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Indications & Clinical Uses

Methotrexate is used across several disease families, primarily targeting immune‑mediated conditions and hematologic malignancies.

  • Rheumatoid arthritis: reduces joint inflammation and slows disease progression.
  • Psoriasis: decreases skin lesion severity and plaque formation.
  • Acute lymphoblastic leukemia: impedes malignant cell proliferation in the bone marrow.
  • Non‑Hodgkin lymphoma: contributes to tumor regression as part of combination chemotherapy.

How It Works

  • Methotrexate inhibits the enzyme dihydrofolate reductase, preventing the conversion of dihydrofolate to tetrahydrofolate. This blockade reduces the cellular pool of tetrahydrofolate needed for synthesis of purine nucleotides and thymidylate, thereby impairing DNA, RNA and protein synthesis. The resulting antiproliferative effect is most pronounced in rapidly dividing immune cells and malignant lymphoid cells. Additionally, at higher doses, methotrexate can increase extracellular adenosine, contributing to its anti‑inflammatory properties.

Side Effects

Methotrexate may cause a range of adverse reactions, varying from mild to severe.

Common Side Effects

  • Nausea: mild to moderate upset stomach.
  • Fatigue: persistent tiredness.
  • Oral ulcers: painful sores in the mouth.
  • Elevated liver enzymes: mild hepatic irritation.

Serious or Rare Side Effects

  • Severe liver toxicity: risk of hepatitis or fibrosis.
  • Pulmonary fibrosis: progressive lung scarring.
  • Bone marrow suppression: profound pancytopenia.
  • Severe infection: opportunistic infections due to immunosuppression.

Precautions & Warnings

When using methotrexate, careful monitoring and specific precautions are essential to minimize risks.

  • Pregnancy contraindication: avoid use in pregnancy due to teratogenicity.
  • Liver monitoring: perform regular liver function tests.
  • Blood count monitoring: check complete blood count before and during therapy.
  • Renal function: adjust dose in patients with impaired kidney function.
  • Drug interactions: avoid concomitant use with NSAIDs and aminoglycosides without supervision.
  • Store at 2-8°C: keep refrigerated, protect from light, do not freeze or shake.

Avoid Interactions

Methotrexate interacts with several medicines; recognizing the level of interaction guides clinical management.

Major Interactions (Avoid)

  • NSAIDs: increase methotrexate toxicity by reducing renal clearance.
  • Aminoglycoside antibiotics: heighten risk of nephrotoxicity.
  • Live vaccines: may cause severe infection due to immunosuppression.

Moderate Interactions (Monitor Closely)

  • Proton pump inhibitors: may alter absorption and increase serum levels.
  • Sulfonamide antibiotics: can enhance hematologic toxicity.
  • Oral contraceptives: may reduce efficacy of hormonal contraception.

Frequently Asked Questions

Injexate contains methotrexate, which is prescribed for autoimmune diseases such as rheumatoid arthritis and psoriasis, as well as for certain cancers including acute lymphoblastic leukemia and non‑Hodgkin lymphoma. It works by modulating the immune response and inhibiting malignant cell growth.

Methotrexate blocks the enzyme dihydrofolate reductase, limiting the production of tetrahydrofolate needed for DNA, RNA and protein synthesis. This antiproliferative action reduces the activity of rapidly dividing immune cells and cancer cells, providing therapeutic benefit in the indicated conditions.

The dosage of Injexate is individualized by the prescribing clinician based on the specific indication, patient weight, renal function and treatment response. Only a qualified healthcare professional should determine the appropriate dose and administration schedule.

Methotrexate is classified as pregnancy category X because it is known to cause fetal harm and is contraindicated during pregnancy. It is also not recommended for breastfeeding mothers, as it can be excreted in breast milk and may affect the infant.

To request Injexate, submit an enquiry on the product page at gnhindia.com indicating the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details (including cold‑chain if needed) and import documentation.

For rheumatoid arthritis, methotrexate (Injexate) is often the first‑line disease‑modifying antirheumatic drug, whereas alternatives such as leflunomide or biologic agents target different pathways. Methotrexate offers a well‑established efficacy profile, oral and injectable options, and lower cost, but requires regular monitoring for toxicity.

Injexate should be stored at 2‑8 °C in a refrigerator, protected from light, and must not be frozen or shaken. Keep the product in its original packaging until use to maintain stability and ensure proper temperature control during transport.

Injexate is supplied as an injectable solution and can be given intramuscularly, intravenously or subcutaneously by a qualified healthcare professional. The route and rate of administration are determined by the prescribing clinician according to the therapeutic indication.

The most critical adverse events include severe liver toxicity, pulmonary fibrosis, profound bone‑marrow suppression leading to pancytopenia, and serious infections due to immunosuppression. Patients should be monitored regularly with liver function tests, pulmonary assessments and complete blood counts.

Injexate is contraindicated in pregnant or breastfeeding individuals, patients with known hypersensitivity to methotrexate, and those with severe hepatic or renal impairment. Caution is also advised for patients with pre‑existing lung disease or uncontrolled infections.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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