Product image of Injexate (Methotrexate) supplied by GNH India

Injexate

Active Ingredient:
Methotrexate
Origin:
EU

Injexate (Methotrexate)

Methotrexate, the active ingredient in Injexate, is an antimetabolite (folate antagonist) presented as a sterile solution for subcutaneous use. It is employed to treat rheumatoid arthritis, psoriasis, acute lymphoblastic leukemia, non‑Hodgkin lymphoma and other malignancies that respond to methotrexate therapy.

GNH India supplies Injexate as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, oncology centres and pharmacies worldwide.

Manufacturer / TM Owner

Accord Healthcare B.V.

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Indications & Clinical Uses

Methotrexate is used across several disease families, primarily inflammatory and malignant conditions.

  • Rheumatoid arthritis: reduces disease activity and joint inflammation in adult patients.
  • Psoriasis: improves skin lesions and slows disease progression.
  • Acute lymphoblastic leukemia: induces remission by targeting rapidly dividing leukemic cells.
  • Non‑Hodgkin lymphoma: contributes to tumor control as part of combination regimens.
  • Other malignancies responsive to methotrexate: provides cytotoxic effect in various solid tumours and hematologic cancers.

How It Works

  • Methotrexate inhibits dihydrofolate reductase, decreasing tetrahydrofolate synthesis. This limits the availability of one‑carbon units required for purine and pyrimidine synthesis, thereby impairing DNA, RNA and protein production in rapidly proliferating cells and modulating immune cell activity.

Side Effects

Methotrexate may cause a range of adverse reactions, from mild to severe.

Common Side Effects

  • Nausea or vomiting.
  • Fatigue or malaise.
  • Oral mucosal ulceration (mouth sores).
  • Transient elevation of liver enzymes.
  • Mild rash or itching.
  • Decreased white blood cell count.

Serious or Rare Side Effects

  • Severe hepatotoxicity or liver fibrosis.
  • Pulmonary toxicity, including interstitial pneumonitis.
  • Life‑threatening infection due to bone‑marrow suppression.
  • Acute renal failure.
  • Severe cutaneous adverse reactions (e.g., Stevens‑Johnson syndrome).
  • Bone‑marrow aplasia leading to pancytopenia.

Precautions & Warnings

Before initiating therapy, clinicians should assess baseline organ function and counsel patients on potential risks.

  • Monitor liver function: perform periodic liver enzyme tests.
  • Monitor blood counts: check complete blood count regularly.
  • Assess renal function: evaluate serum creatinine and adjust dose if needed.
  • Avoid use in pregnancy: methotrexate is teratogenic and contraindicated.
  • Review concomitant nephrotoxic or hepatotoxic drugs: adjust therapy to reduce cumulative toxicity.
  • Store at 2-8°C: keep refrigerated, protect from light, do not freeze or shake.

Avoid Interactions

Methotrexate interacts with several medicines that may alter its safety or efficacy.

Major Interactions (Avoid)

  • Non‑steroidal anti‑inflammatory drugs (NSAIDs): increase risk of renal toxicity.
  • Trimethoprim‑sulfamethoxazole: additive bone‑marrow suppression.
  • Live vaccines: heightened risk of infection.

Moderate Interactions (Monitor Closely)

  • Azathioprine: enhanced myelosuppression when combined.
  • Phenytoin: may reduce methotrexate plasma concentrations.
  • Folic acid supplements: can diminish therapeutic effect if not timed appropriately.

Frequently Asked Questions

Injexate, containing methotrexate, is prescribed for inflammatory disorders such as rheumatoid arthritis and psoriasis, as well as for certain cancers including acute lymphoblastic leukemia, non‑Hodgkin lymphoma, and other malignancies that are known to respond to methotrexate therapy.

Methotrexate blocks the enzyme dihydrofolate reductase, which reduces the production of tetrahydrofolate. This limits the synthesis of nucleotides needed for DNA, RNA and protein formation, thereby inhibiting the growth of rapidly dividing cells and modulating immune responses.

The specific dose of Injexate is determined by the prescribing clinician based on the patient’s condition, weight, renal function and treatment goals. Dosage regimens vary widely across indications and must be individualized.

Methotrexate is classified as teratogenic and is contraindicated during pregnancy. Women of child‑bearing potential should use effective contraception. Limited data exist for breastfeeding, and the drug may be excreted in milk, so use is generally avoided.

To place an order, submit an enquiry on the Injexate product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details (including cold‑chain if needed) and import documentation.

Injexate (methotrexate) is a folate antagonist, whereas other antimetabolites such as 5‑fluorouracil target thymidylate synthase. Methotrexate has a broader range of approved indications, including both autoimmune diseases and various cancers, and its dosing flexibility (oral, intramuscular, subcutaneous) differs from many alternatives.

Injexate should be stored at 2‑8 °C, kept refrigerated, protected from light, and must not be frozen or shaken. Maintain the product in its original packaging until use to preserve stability.

Injexate is given by subcutaneous injection. The injection site is typically rotated to reduce local irritation, and the volume is administered using a sterile technique as directed by the healthcare professional.

The most serious risks include severe liver toxicity, pulmonary fibrosis, life‑threatening infections due to bone‑marrow suppression, acute renal failure, and rare but severe cutaneous reactions such as Stevens‑Johnson syndrome. Patients should be monitored closely for these events.

Injexate is contraindicated in pregnant women, individuals with severe hepatic or renal impairment, patients with known hypersensitivity to methotrexate, and those receiving live vaccines. Caution is also advised for patients with pre‑existing blood dyscrasias.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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