Product image of Inlyta (Axitinib) supplied by GNH India

Inlyta

Active Ingredient:
Axitinib
Origin:
EU

Inlyta (Axitinib)

Axitinib, the active ingredient in Inlyta, is a tyrosine kinase inhibitor presented as a tablet for oral use. It treats advanced or metastatic renal cell carcinoma, typically after prior systemic therapy.

GNH India supplies Inlyta as a licensed, GDP-compliant international pharmaceutical supplier serving hospitals, oncology centres and pharmacies worldwide.

Manufacturer / TM Owner

Pfizer Europe Ma Eeig

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Indications & Clinical Uses

  • Inlyta (axitinib) is indicated for cancers that depend on vascular endothelial growth factor signaling.
  • Metastatic renal cell carcinoma: improves progression‑free survival after prior systemic therapy
  • Advanced renal cell carcinoma: used when disease has progressed following first‑line treatment
  • Kidney cancer (clear‑cell): indicated for patients with progressive disease after earlier therapy

How It Works

  • Axitinib selectively inhibits the tyrosine kinase activity of vascular endothelial growth factor receptors VEGFR‑1, VEGFR‑2 and VEGFR‑3. Blocking these receptors suppresses angiogenic signaling, reducing new blood‑vessel formation that tumors need for growth and metastasis.

Side Effects

Common Side Effects

  • Hypertension: elevated blood pressure requiring monitoring
  • Diarrhea: watery stools that may lead to dehydration
  • Fatigue: persistent tiredness affecting daily activities
  • Nausea: feeling of sickness often accompanied by loss of appetite
  • Decreased appetite: reduced desire to eat, potentially causing weight loss
  • Hand‑foot syndrome: redness or swelling of palms and soles

Serious or Rare Side Effects

  • Arterial thromboembolism: risk of heart attack or stroke
  • Gastrointestinal perforation: possible tearing of the stomach or intestines
  • Severe hemorrhage: uncontrolled bleeding in various organs
  • Hepatic failure: serious liver injury with elevated enzymes

Precautions & Warnings

  • Patients receiving Inlyta should be monitored closely for cardiovascular and hepatic safety.
  • Blood pressure monitoring: check regularly due to risk of hypertension
  • Cardiovascular assessment: evaluate for history of arterial events before starting therapy
  • Liver function tests: monitor for hepatic toxicity during treatment
  • Bleeding risk: assess before surgery or when using anticoagulants
  • Pregnancy and lactation: avoid use; discuss risks with physician
  • Store at ambient temperature: keep below 25°C in original container, protect from moisture

Avoid Interactions

Axitinib may interact with several medications; careful review is advised.

Major Interactions (Avoid)

  • Strong CYP3A4 inhibitors (e.g., ketoconazole): may increase axitinib exposure
  • Potent CYP3A4 inducers (e.g., rifampin): may reduce efficacy
  • Anticoagulants (e.g., warfarin): increased bleeding risk

Moderate Interactions (Monitor Closely)

  • Antihypertensives: may require dose adjustment due to additive blood‑pressure effects
  • Diuretics: monitor electrolytes and renal function
  • Other VEGF inhibitors: additive toxicity, especially hypertension and proteinuria

Frequently Asked Questions

Inlyta (axitinib) is a prescription medication indicated for treatment of advanced or metastatic renal cell carcinoma, particularly in patients whose disease has progressed after prior systemic therapy. It works as an anti‑angiogenic agent to inhibit tumor blood‑vessel formation, helping to control disease spread.

Axitinib selectively blocks the tyrosine kinase activity of vascular endothelial growth factor receptors VEGFR‑1, VEGFR‑2 and VEGFR‑3. By inhibiting these receptors, it reduces signaling that promotes new blood‑vessel growth (angiogenesis) within tumors, thereby limiting nutrient supply and tumor progression.

The specific dose of Inlyta is determined by the prescribing physician based on individual patient factors, including prior treatments, renal function, and tolerability. The prescriber will select the appropriate tablet strength and dosing schedule in accordance with approved labeling and clinical guidelines.

Safety data for axitinib in pregnancy and lactation are limited, and the drug may pose risks to the fetus or nursing infant. It is generally contraindicated in pregnant or breastfeeding women unless the potential benefit justifies the risk, and effective contraception is recommended during treatment.

To request Inlyta, submit an enquiry on the product page at gnhindia.com specifying the required quantity. GNH India supplies hospitals, pharmacies and procurement teams worldwide, and will verify trade or institutional credentials before providing pricing, availability, shipping details (including any required temperature control) and import documentation.

Inlyta belongs to the class of VEGFR tyrosine‑kinase inhibitors, similar to drugs such as sunitinib and pazopanib. Compared with some alternatives, axitinib is often used after progression on first‑line therapy and may offer a different side‑effect profile, particularly a higher incidence of hypertension but lower rates of certain cytopenias. Choice of therapy depends on prior treatment history and patient tolerance.

Inlyta tablets should be stored at ambient temperature, below 25 °C, in their original container to protect them from moisture and light. Keep the medication out of reach of children and do not use if the packaging is damaged or the tablets appear discolored.

Inlyta is taken orally, usually once daily, with or without food, as directed by the treating physician. Patients should swallow the tablet whole with a glass of water and follow any specific instructions regarding timing relative to other medications or meals. Consistent daily intake helps maintain steady drug levels.

The most serious risks of Inlyta include severe hypertension, arterial thromboembolic events such as heart attack or stroke, gastrointestinal perforation, and rare but potentially fatal hemorrhage. Patients should be monitored closely for signs of these events, and any sudden severe symptoms should prompt immediate medical attention.

Inlyta is contraindicated in patients with known hypersensitivity to axitinib or any tablet excipients. It should be used with caution, or avoided, in individuals with uncontrolled hypertension, recent major cardiovascular events, active bleeding disorders, or severe hepatic impairment. Pregnant or breastfeeding women should also avoid the medication unless the benefits outweigh the risks.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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