Product image of Innohep (Tinzaparin Sodium) supplied by GNH India

Innohep

Active Ingredient:
Tinzaparin Sodium
Origin:
EU

Innohep (Tinzaparin Sodium)

Tinzaparin sodium, the active ingredient in Innohep, is a low molecular weight heparin presented as an injection solution for intravenous and subcutaneous use. It treats and prevents thromboembolic disorders such as deep vein thrombosis and pulmonary embolism in at‑risk patients.

GNH India supplies Innohep as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, transplant centres, oncology centres, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Leo Pharma A/S

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Indications & Clinical Uses

Innohep, a low molecular weight heparin, is used in several thrombo‑vascular conditions.

  • Deep vein thrombosis (DVT) prophylaxis: prevents clot formation in surgical and immobilised patients.
  • Acute deep vein thrombosis treatment: facilitates resolution of existing venous clots.
  • Pulmonary embolism prevention and treatment: reduces risk of embolic events in high‑risk individuals.
  • Acute coronary syndrome management: helps prevent further coronary thrombosis during the acute phase.

How It Works

  • Tinzaparin sodium potentiates antithrombin III, which accelerates the inhibition of activated factor Xa and, to a lesser extent, factor IIa (thrombin). This reduces thrombin generation and fibrin formation, thereby limiting clot propagation in the venous and arterial circulation.

Side Effects

Common Side Effects

  • Injection‑site bruising or pain.
  • Mild bleeding such as epistaxis or gum bleeding.
  • Nausea or gastrointestinal discomfort.
  • Headache or dizziness.
  • Transient elevation of liver enzymes.
  • Local erythema at the injection site.

Serious or Rare Side Effects

  • Major hemorrhage (intracranial, gastrointestinal).
  • Heparin‑induced thrombocytopenia (HIT).
  • Severe allergic reactions including anaphylaxis.
  • Skin necrosis at injection sites.
  • Spinal or epidural hematoma following neuraxial procedures.
  • Thrombosis despite therapy (rebound clotting).

Precautions & Warnings

Before using Innohep, consider the following precautions.

  • Renal impairment: assess renal function and adjust dose if necessary.
  • Hepatic dysfunction: monitor liver enzymes and coagulation parameters.
  • Concomitant anticoagulants or antiplatelet agents: increased risk of bleeding; use with caution.
  • Recent surgery or trauma: heightened bleeding risk; evaluate timing of administration.
  • Pregnancy and lactation: safety not established; weigh benefits against potential risks.
  • Store at 2-8°C: keep refrigerated, protect from light, do not freeze or shake.

Avoid Interactions

Innohep may interact with several medicines; monitor patients accordingly.

Major Interactions (Avoid)

  • Other anticoagulants (e.g., warfarin, direct oral anticoagulants): additive bleeding risk.
  • Thrombolytic agents (e.g., alteplase): may cause severe hemorrhage.
  • Non‑steroidal anti‑inflammatory drugs (NSAIDs): increase gastrointestinal bleeding.

Moderate Interactions (Monitor Closely)

  • Antiplatelet drugs (e.g., clopidogrel): heightened bleeding tendency.
  • Certain antibiotics (e.g., vancomycin): may alter anticoagulant effect.
  • Corticosteroids: potential for mucosal bleeding.
  • ACE inhibitors or diuretics: monitor renal function and electrolytes.

Frequently Asked Questions

Innohep is indicated for the prevention of deep vein thrombosis in surgical or immobilised patients, the treatment of acute deep vein thrombosis, the prevention and treatment of pulmonary embolism, and for reducing clot formation in patients with acute coronary syndrome.

Tinzaparin sodium enhances the activity of antithrombin III, leading to selective inhibition of factor Xa and, to a lesser extent, factor IIa (thrombin). This action reduces thrombin generation, limits fibrin formation, and thereby prevents the growth and propagation of blood clots.

The dose of Innohep is individualized by the prescribing clinician based on the patient’s indication, weight, renal function, and overall risk profile. Healthcare professionals determine the appropriate amount and frequency according to current clinical guidelines.

Safety data for tinzaparin sodium in pregnancy and lactation are limited. The product should only be used if the potential benefit justifies any possible risk to the fetus or infant, and the decision must be made by a qualified healthcare provider.

To place an order, submit an enquiry on the Innohep product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies, and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details (including cold‑chain if needed), and import documentation.

Innohep (tinzaparin) has a longer half‑life and a higher anti‑Xa to anti‑IIa activity ratio compared with some other LMWHs, which may allow once‑daily dosing in certain settings. Its safety and efficacy profile are comparable, but specific clinical decisions depend on patient characteristics and therapeutic goals.

Innohep should be stored at 2‑8 °C (refrigerated). Keep the vials in their original packaging, protect them from light, and avoid freezing or shaking the solution, as these actions can compromise product stability.

Innohep is supplied as a sterile injection solution for subcutaneous or intravenous administration. The injection is typically given into the abdominal wall or thigh using a sterile needle, following aseptic technique and the dosing instructions provided by the prescriber.

The most serious risks include major bleeding events such as intracranial or gastrointestinal hemorrhage, heparin‑induced thrombocytopenia (HIT), and rare allergic reactions that can be life‑threatening. Patients should be monitored closely for signs of bleeding or platelet count changes.

Innohep is contraindicated in patients with known hypersensitivity to tinzaparin or any heparin product, those with active major bleeding, and individuals who have a history of heparin‑induced thrombocytopenia. Caution is also advised for patients with severe renal impairment.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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