Product image of Innovair (Formoterol Fumarate Dihydrate, Beclometasone Dipropionate Anhydrous) supplied by GNH India

Innovair

Active Ingredient:
Formoterol Fumarate Dihydrate, Beclometasone Dipropionate Anhydrous
Origin:
EU

Innovair (Formoterol Fumarate Dihydrate, Beclometasone Dipropionate Anhydrous)

Beclometasone dipropionate and Formoterol fumarate, the active ingredients in Innovair, are an inhaled corticosteroid/long‑acting β2‑agonist presented as a fixed‑dose inhalation aerosol for inhalation use. The combination treats asthma and chronic obstructive pulmonary disease (COPD) as a maintenance therapy in adults and adolescents who require regular control of airway inflammation and bronchodilation.

GNH India supplies Innovair as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Chiesi S.A.S.

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Indications & Clinical Uses

  • Innovair is indicated for chronic respiratory diseases where airway inflammation and bronchoconstriction require long‑term control.
  • Asthma: improves symptom control and reduces the frequency of exacerbations in patients needing maintenance therapy.
  • COPD: provides sustained bronchodilation and anti‑inflammatory effects to help prevent worsening of symptoms and exacerbations.
  • Severe asthma: used as step‑3 or step‑4 therapy when inhaled corticosteroid alone is insufficient.

How It Works

  • Beclometasone dipropionate binds to glucocorticoid receptors in airway cells, suppressing inflammatory gene expression and reducing airway edema. Formoterol fumarate stimulates β2‑adrenergic receptors on bronchial smooth muscle, leading to cyclic AMP accumulation and prolonged bronchodilation. The combined action delivers both anti‑inflammatory and bronchodilatory effects, improving airway patency and control of chronic respiratory symptoms.

Side Effects

Like all inhaled corticosteroid/LABA combinations, Innovair may cause a range of adverse reactions.

Common Side Effects

  • Throat irritation or soreness
  • Hoarseness or voice changes
  • Oral candidiasis (thrush)
  • Cough or wheeze after inhalation
  • Headache
  • Tremor or shakiness

Serious or Rare Side Effects

  • Paradoxical bronchospasm
  • Adrenal suppression with prolonged use
  • Decreased bone mineral density
  • Allergic reactions including anaphylaxis
  • Pneumonia, especially in COPD patients
  • Cardiac arrhythmias or tachycardia

Precautions & Warnings

  • Before prescribing Innovair, clinicians should evaluate patient‑specific risk factors and provide guidance on proper use.
  • Assess infection risk: evaluate for active respiratory infections before initiating therapy.
  • Monitor growth: in pediatric patients, regularly assess growth velocity.
  • Screen for tuberculosis: consider testing prior to long‑term corticosteroid use.
  • Avoid abrupt discontinuation: taper if therapy is stopped after prolonged use.
  • Use spacer device: to reduce oropharyngeal deposition and local side effects.
  • Store below 25°C: keep in the original pack, protect from moisture and heat.

Avoid Interactions

Innovair may interact with several drug classes; careful assessment is required.

Major Interactions (Avoid)

  • Beta‑blockers: may reduce bronchodilator effect and precipitate bronchospasm.
  • Strong CYP3A4 inhibitors (e.g., ketoconazole): increase systemic exposure to formoterol.
  • MAO inhibitors: may enhance sympathomimetic effects of formoterol.
  • Other inhaled corticosteroids: increase risk of systemic corticosteroid effects.
  • Diuretics: may potentiate hypokalemia caused by β2‑agonists.

Moderate Interactions (Monitor Closely)

  • Ritonavir: may raise formoterol levels, monitor for tachycardia.
  • Theophylline: additive stimulant effect on the heart, observe for arrhythmias.
  • Diabetes medications: β2‑agonists can raise blood glucose, adjust monitoring.
  • Anticholinergics: combined bronchodilation may increase risk of dry mouth.
  • Live vaccines: consider timing due to immunosuppression risk.

Frequently Asked Questions

Innovair is a prescription inhaler that combines an inhaled corticosteroid with a long‑acting β2‑agonist. It is used as maintenance therapy to control symptoms and reduce exacerbations in patients with asthma or chronic obstructive pulmonary disease (COPD) who require regular, long‑term treatment.

Beclometasone dipropionate binds to glucocorticoid receptors in airway cells, suppressing inflammatory pathways and decreasing swelling. Formoterol fumarate activates β2‑adrenergic receptors on bronchial smooth muscle, increasing cyclic AMP and causing prolonged bronchodilation. Together they provide anti‑inflammatory and bronchodilatory effects for better airway control.

The dose of Innovair is individualized by the prescribing clinician based on disease severity, age, and response to therapy. Typically, patients inhale a fixed number of puffs twice daily, but exact dosing and frequency must be determined by a qualified healthcare professional.

Safety data for Innovair in pregnancy and lactation are limited. The product should only be used if the potential benefit to the mother outweighs any possible risk to the fetus or infant. Women who are pregnant, planning pregnancy, or breastfeeding should discuss treatment options with their healthcare provider.

To order Innovair, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies, and procurement teams worldwide, and will request verification of trade or institutional credentials. After confirmation, the team provides pricing, availability, shipping details (including any cold‑chain requirements), and assists with import documentation.

Innovair combines an inhaled corticosteroid and a long‑acting β2‑agonist in a single device, offering convenience over separate inhalers. Compared with single‑component products, it provides both anti‑inflammatory and bronchodilator actions, which can improve adherence. Its efficacy and safety profile are similar to other approved ICS/LABA combinations, but choice may depend on device preference, dosing schedule, and individual patient response.

Innovair should be stored below 25 °C in its original packaging, protected from moisture and direct heat. Keep the inhaler cap tightly closed when not in use. Do not expose the device to freezing temperatures or extreme humidity, and avoid cleaning the mouthpiece with solvents; a dry cloth is sufficient.

Innovair is delivered via inhalation using a metered‑dose inhaler. The patient should shake the inhaler gently, exhale fully, place the mouthpiece in the mouth, and inhale slowly and deeply while actuating the device. Holding the breath for about 10 seconds after inhalation maximizes drug deposition. A spacer can be used to reduce oropharyngeal exposure.

Serious risks include paradoxical bronchospasm, adrenal suppression with prolonged high‑dose use, reduced bone mineral density, severe allergic reactions such as anaphylaxis, and cardiac effects like tachycardia or arrhythmias. Patients should seek immediate medical attention if they experience sudden worsening of breathing, severe palpitations, or signs of an allergic reaction.

Innovair is contraindicated in individuals with known hypersensitivity to beclometasone dipropionate, formoterol fumarate, or any excipients in the inhaler. It should also be avoided in patients who have experienced a severe hypersensitivity reaction to other inhaled corticosteroid/LABA combinations. Caution is advised for patients with uncontrolled cardiovascular disease, severe arrhythmias, or active infections.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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