Product image of Innovair (Formoterol Fumarate Dihydrate, Beclometasone Dipropionate Anhydrous) supplied by GNH India

Innovair

Active Ingredient:
Formoterol Fumarate Dihydrate, Beclometasone Dipropionate Anhydrous
Origin:
EU

Innovair (Formoterol Fumarate Dihydrate, Beclometasone Dipropionate Anhydrous)

Formoterol fumarate, the active ingredient in Innovair, is a combination inhaled corticosteroid/long‑acting β2‑agonist presented as a metered dose inhaler for inhalation use. It treats asthma and chronic obstructive pulmonary disease as maintenance therapy in adults and children.

GNH India supplies Innovair as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Chiesi Farmaceutici S.P.A.

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Indications & Clinical Uses

Innovair is a combination inhaled corticosteroid/long‑acting β2‑agonist indicated for maintenance therapy in airway diseases.

  • Asthma: improves symptom control and reduces the frequency of exacerbations.
  • Chronic obstructive pulmonary disease (COPD): maintains lung function, decreases breathlessness and lowers exacerbation risk.
  • Exercise‑induced bronchoconstriction (as part of asthma management): provides sustained bronchodilation to prevent exercise‑related airway narrowing.

How It Works

  • Beclometasone dipropionate activates glucocorticoid receptors in airway cells, suppressing inflammatory gene expression and reducing airway edema. Formoterol fumarate binds to β2‑adrenergic receptors on bronchial smooth muscle, stimulating adenylate cyclase, increasing cAMP levels, and producing prolonged bronchodilation. The combined actions address both inflammation and bronchoconstriction, supporting long‑term airway stability.

Side Effects

Adverse reactions may occur with any inhaled therapy. Patients should be aware of both frequent and less common events.

Common Side Effects

  • Oral candidiasis: fungal infection of the mouth.
  • Hoarseness or dysphonia: voice changes after inhalation.
  • Throat irritation or dry mouth.
  • Cough or wheeze immediately after use.
  • Headache.
  • Tremor.

Serious or Rare Side Effects

  • Paradoxical bronchospasm: sudden worsening of breathing.
  • Adrenal suppression: reduced endogenous cortisol production.
  • Pneumonia: especially in COPD patients.
  • Cardiac arrhythmias or tachycardia.
  • Severe allergic reactions: rash, swelling, anaphylaxis.
  • Hyperglycaemia: elevated blood glucose levels.

Precautions & Warnings

Before prescribing Innovair, clinicians should consider several safety aspects.

  • Monitor for oral candidiasis: advise rinsing mouth after each inhalation.
  • Assess adrenal function: especially with high‑dose or prolonged use.
  • Use cautiously in patients with cardiovascular disease: monitor heart rate and blood pressure.
  • Avoid abrupt discontinuation: taper to prevent loss of asthma control.
  • Store at room temperature: keep inhaler in original packaging, protect from moisture and heat.

Avoid Interactions

Innovair may interact with other medicines, requiring attention to avoid reduced efficacy or increased toxicity.

Major Interactions (Avoid)

  • Beta‑blockers: may diminish bronchodilator response.
  • Potent CYP3A4 inhibitors (e.g., ketoconazole): can raise corticosteroid exposure.
  • Monoamine oxidase inhibitors (MAOIs): may enhance sympathomimetic effects of formoterol.
  • Diuretics: increase risk of hypokalaemia when combined with β2‑agonists.

Moderate Interactions (Monitor Closely)

  • Concomitant inhaled corticosteroids: risk of systemic glucocorticoid effects.
  • Other LABA or sympathomimetic agents: additive cardiovascular stimulation.
  • Ritonavir or other strong CYP3A4 inhibitors: may elevate formoterol plasma levels.

Frequently Asked Questions

Innovair is a prescription inhaler that combines an inhaled corticosteroid with a long‑acting β2‑agonist. It is indicated for the maintenance treatment of asthma and chronic obstructive pulmonary disease (COPD), helping to control symptoms, reduce inflammation, and prevent exacerbations when used regularly as part of a long‑term management plan.

Beclometasone dipropionate binds to glucocorticoid receptors in airway cells, suppressing inflammatory mediators and decreasing swelling. Formoterol fumarate stimulates β2‑adrenergic receptors on bronchial smooth muscle, raising cyclic AMP levels and causing prolonged bronchodilation. Together they address both the inflammatory and bronchoconstrictive components of asthma and COPD.

The dose of Innovair is individualized by the prescribing healthcare professional based on disease severity, age, and response to therapy. The prescriber determines the number of inhalations per day and the total daily dose, which should be followed exactly as instructed on the prescription label.

Safety data for Innovair in pregnancy and lactation are limited. The medication should only be used if the potential benefit justifies any possible risk to the fetus or infant. Women who are pregnant, planning to become pregnant, or breastfeeding should discuss the risks and benefits with their healthcare provider.

To order Innovair, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies, and procurement teams worldwide, and will request verification of trade or institutional credentials. After confirmation, the team provides pricing, availability, shipping details (including any cold‑chain requirements), and assists with import documentation.

Innovair combines a corticosteroid (beclometasone) with a long‑acting β2‑agonist (formoterol) in a single metered‑dose inhaler, offering convenience over separate inhalers. Compared with products that contain only a steroid or only a bronchodilator, Innovair provides dual action, which can improve adherence and simplify regimens. Its efficacy is comparable to other combination inhalers such as fluticasone/salmeterol, but individual response may vary.

Innovair should be stored at room temperature, below 25 °C (77 °F). Keep the inhaler in its original packaging, protect it from moisture and direct heat, and avoid exposing it to freezing temperatures. Do not puncture or tamper with the canister, and replace the inhaler after the indicated number of doses has been used.

Innovair is delivered via a metered‑dose inhaler (MDI). The patient should shake the inhaler well, exhale fully, place the mouthpiece in the mouth, and press down on the canister while inhaling slowly and deeply. Hold the breath for about 10 seconds, then exhale slowly. The inhaler should be rinsed with water after use to reduce the risk of oral thrush.

Serious adverse events, although uncommon, include paradoxical bronchospasm (sudden worsening of breathing), adrenal suppression, severe allergic reactions such as anaphylaxis, pneumonia (particularly in COPD patients), and cardiac arrhythmias or tachycardia. Patients should seek immediate medical attention if they experience sudden breathlessness, swelling, rash, or irregular heartbeats.

Innovair is contraindicated in individuals with a known hypersensitivity to beclometasone, formoterol, or any component of the inhaler. It should also be avoided in patients who have experienced a severe paradoxical bronchospasm with a β2‑agonist. Caution is advised for patients with uncontrolled cardiovascular disease, severe hypertension, or hyperthyroidism, and the drug should be used only under medical supervision in these cases.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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