Product image of Innovair Nexthaler (Formoterol Fumarate Dihydrate, Beclometasone Dipropionate Anhydrous) supplied by GNH India

Innovair Nexthaler

Active Ingredient:
Formoterol Fumarate Dihydrate, Beclometasone Dipropionate Anhydrous
Origin:
EU

Innovair Nexthaler (Formoterol Fumarate Dihydrate, Beclometasone Dipropionate Anhydrous)

Formoterol fumarate dihydrate and beclometasone dipropionate anhydrous, the active ingredients in Innovair Nexthaler, are a LABA/ICS combination presented as a dry powder inhaler for inhalation use. It provides maintenance therapy for asthma and chronic obstructive pulmonary disease (COPD) in adults and adolescents.

GNH India supplies Innovair Nexthaler as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide across multiple regions.

Manufacturer / TM Owner

Chiesi Farmaceutici S.P.A.

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Indications & Clinical Uses

  • Innovair Nexthaler combines a long‑acting β2‑agonist and an inhaled corticosteroid to control airway inflammation and bronchoconstriction.
  • Asthma: improves symptom control and reduces the frequency of exacerbations
  • COPD: enhances lung function and decreases the risk of flare‑ups

How It Works

  • Formoterol fumarate dihydrate binds to β2‑adrenergic receptors on airway smooth muscle, activating adenylate cyclase and raising cyclic AMP levels, which relaxes the muscle and yields prolonged bronchodilation. Beclometasone dipropionate anhydrous penetrates airway cells, binds glucocorticoid receptors, and modulates gene transcription to suppress inflammatory cytokines, reduce eosinophil activity, and diminish airway edema, together providing sustained airway protection.

Side Effects

The inhaled combination may cause a range of adverse reactions, varying in frequency and severity.

Common Side Effects

  • Throat irritation or soreness
  • Cough
  • Hoarseness or voice change
  • Oral candidiasis (thrush)

Serious or Rare Side Effects

  • Paradoxical bronchospasm
  • Severe allergic reaction (anaphylaxis)
  • Pneumonia

Precautions & Warnings

Before initiating therapy, consider the following precautions.

  • Inhaler technique: ensure correct use to maximize drug delivery
  • Oral hygiene: rinse mouth after each dose to reduce risk of thrush
  • Cardiovascular status: monitor heart rate and blood pressure, especially in patients with arrhythmias
  • Dose titration: use the lowest effective dose to control symptoms
  • Pregnancy and lactation: assess risk‑benefit before prescribing
  • Store at ambient temperature: keep in original container, protect from moisture and heat

Avoid Interactions

Review potential drug interactions prior to prescribing.

Major Interactions (Avoid)

  • Beta‑blockers: may diminish bronchodilator effect and precipitate bronchospasm
  • Potent CYP3A4 inhibitors (e.g., ketoconazole, itraconazole): can increase systemic corticosteroid exposure

Moderate Interactions (Monitor Closely)

  • Diuretics: may enhance hypokalemia risk when combined with β2‑agonist
  • Theophylline: additive stimulant effect on heart rate
  • Anticholinergic bronchodilators: may cause excessive bronchodilation

Frequently Asked Questions

Innovair Nexthaler is a fixed‑dose inhalation product that combines a long‑acting β2‑agonist with an inhaled corticosteroid. It is prescribed as a maintenance therapy to control symptoms and reduce exacerbations in patients with asthma or chronic obstructive pulmonary disease (COPD).

Formoterol is a long‑acting β2‑adrenergic agonist. It binds to β2 receptors on airway smooth muscle, stimulating adenylate cyclase and increasing cyclic AMP. The rise in cyclic AMP leads to relaxation of the smooth muscle, producing sustained bronchodilation that helps keep the airways open.

The prescribed dose of Innovair Nexthaler is individualized by the treating physician based on the patient’s severity of disease, age, and response to therapy. The prescriber determines the number of inhalations per day and any dose adjustments required for optimal control.

Safety data for Innovair Nexthaler in pregnancy and lactation are limited. Clinicians should weigh the potential benefits against possible risks and consider alternative treatments when appropriate. If therapy is deemed necessary, it should be used at the lowest effective dose and under close medical supervision.

To place an order, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India supplies hospitals, pharmacies and procurement teams worldwide, and will request verification of trade or institutional credentials. The sales team then replies with pricing, availability, shipping details and any required import documentation.

Innovair Nexthaler delivers its active ingredients via a dry‑powder Nexthaler device, which provides breath‑actuated dosing without the need for propellants. Compared with metered‑dose inhalers, the dry‑powder system may offer more consistent dose delivery and reduced coordination requirements, while the pharmacologic profile of formoterol and beclometasone is similar to other LABA/ICS combinations.

Innovair Nexthaler should be stored at ambient temperature, below 25 °C, in its original packaging. Keep the device away from moisture, direct sunlight and excessive heat to maintain dose integrity and device functionality.

The patient inhales the medication through the Nexthaler device by taking a steady, deep breath through the mouthpiece. No propellant is required; the inhaler releases a measured dose of dry powder when the patient’s inspiratory flow reaches the required threshold. After each use, the mouthpiece should be closed to protect the dose.

Serious risks include paradoxical bronchospasm, which can worsen breathing, and severe allergic reactions such as anaphylaxis. In rare cases, prolonged high‑dose use may lead to adrenal suppression. Patients should be educated to seek immediate medical attention if they experience sudden breathlessness, swelling, rash, or other signs of a severe reaction.

Innovair Nexthaler is contraindicated in individuals with a known hypersensitivity to formoterol, beclometasone, or any excipients in the formulation. It should also be avoided in patients who have experienced a severe allergic reaction to other inhaled corticosteroids or long‑acting β2‑agonists.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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