Product image of Innozide (Enalapril Maleate, Hydrochlorothiazide) supplied by GNH India

Innozide

Active Ingredient:
Enalapril Maleate, Hydrochlorothiazide
Origin:
EU

Innozide (Enalapril Maleate, Hydrochlorothiazide)

Enalapril maleate and hydrochlorothiazide, the active ingredients in Innozide, are an ACE inhibitor and thiazide diuretic combination presented as an oral tablet for hypertension and heart failure treatment in adult patients. The formulation reduces blood pressure by inhibiting angiotensin‑converting enzyme and promoting sodium excretion, thereby improving cardiovascular outcomes. It is indicated for patients who require combined antihypertensive therapy and is often used when monotherapy does not achieve target blood pressure. The fixed‑dose combination simplifies dosing schedules and may improve adherence.

GNH India supplies Innozide as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Organon Pharma (Uk) Limited

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Indications & Clinical Uses

Innozide, a combined ACE‑inhibitor and thiazide diuretic, is employed in cardiovascular disease management.

  • Hypertension: lowers elevated blood pressure when monotherapy is insufficient.
  • Heart failure: used as adjunct therapy to improve fluid balance and reduce cardiac workload.

How It Works

  • Enalapril maleate blocks the conversion of angiotensin I to angiotensin II by inhibiting angiotensin‑converting enzyme, leading to vasodilation and reduced aldosterone secretion. Hydrochlorothiazide acts on the distal convoluted tubule, inhibiting Na⁺/Cl⁻ reabsorption, which increases urinary sodium and water excretion, decreasing plasma volume. The combined actions produce additive antihypertensive effects by reducing vascular resistance and circulating fluid volume. This dual mechanism helps achieve blood pressure control more efficiently than either component alone.

Side Effects

Innozide may cause a range of adverse reactions, varying from mild to severe.

Common Side Effects

  • Cough: dry, persistent cough.
  • Dizziness: light‑headedness on standing.
  • Headache.
  • Increased urination.

Serious or Rare Side Effects

  • Angioedema: swelling of face, lips, tongue.
  • Severe hypotension: marked blood pressure drop.
  • Acute kidney injury: sudden decline in renal function.
  • Hyperkalemia: elevated potassium levels.

Precautions & Warnings

Before initiating Innozide, clinicians should consider several safety aspects.

  • Monitor blood pressure: ensure adequate control and avoid excessive lowering.
  • Assess renal function: check serum creatinine and eGFR before and during therapy.
  • Check electrolytes: especially potassium and sodium levels.
  • Avoid use in pregnancy: category D, risk to fetus.
  • Store at ambient temperature: keep below 25°C in original packaging, protect from moisture.

Avoid Interactions

Innozide can interact with other medicines, requiring careful review.

Major Interactions (Avoid)

  • Potassium‑sparing diuretics or supplements: risk of hyperkalemia.
  • NSAIDs: may reduce antihypertensive effect and impair renal function.
  • Lithium: increased lithium levels and toxicity.

Moderate Interactions (Monitor Closely)

  • Other antihypertensives: additive blood pressure lowering.
  • ACE inhibitor or ARB combinations: increased risk of renal impairment.
  • Diuretics with other electrolytes: monitor for electrolyte imbalance.

Frequently Asked Questions

Innozide is a prescription medication that combines an ACE inhibitor with a thiazide diuretic. It is primarily used to lower high blood pressure (hypertension) and as an adjunct treatment for heart failure, helping to control fluid overload and improve cardiac function.

Enalapril maleate blocks the angiotensin‑converting enzyme, preventing the formation of angiotensin II. This leads to vasodilation, reduced aldosterone release, and lower systemic vascular resistance, which together help to decrease blood pressure.

The appropriate dose of Innozide is individualized by the prescribing clinician based on the patient’s blood pressure, kidney function, electrolyte status, and response to therapy. No fixed dosing regimen is provided here; the prescriber sets the regimen.

Innozide is classified as pregnancy category D, indicating evidence of risk to the fetus. It is generally not recommended for use during pregnancy or while breastfeeding, and alternative therapies should be considered.

To order Innozide, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India supplies hospitals, pharmacies, and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details, and any necessary import documentation.

Innozide offers a fixed‑dose combination of an ACE inhibitor and a thiazide diuretic, providing additive blood‑pressure reduction in a single tablet. Compared with separate agents, it simplifies dosing and may improve adherence, while offering similar efficacy to other combination products such as ARB‑diuretic pairs.

Innozide tablets should be stored at ambient temperature, preferably below 25 °C. Keep the product in its original container, protect it from moisture and direct sunlight, and ensure the packaging remains tightly closed until use.

Innozide is taken orally, usually once daily, with or without food, as directed by a healthcare professional. The tablet should be swallowed whole with a glass of water and not crushed or chewed unless specifically instructed.

Serious adverse events can include angioedema (swelling of the face, lips, tongue), severe hypotension, acute kidney injury, and hyperkalemia. Patients should seek immediate medical attention if they experience any signs of these conditions.

Innozide should be avoided in individuals with known hypersensitivity to ACE inhibitors or thiazide diuretics, those with severe renal impairment, hyperkalemia, or a history of angioedema. It is also contraindicated during pregnancy and should be used with caution in elderly patients.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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