Product image of Inovum (Olmesartan Medoxomil, Amlodipine) supplied by GNH India

Inovum

Active Ingredient:
Olmesartan Medoxomil, Amlodipine
Origin:
EU

Inovum (Olmesartan Medoxomil, Amlodipine)

Olmesartan medoxomil / amlodipine, the active ingredient in Inovum, is a Angiotensin II receptor blocker (ARB) and calcium channel blocker (CCB) presented as an oral tablet for oral use. It treats hypertension in adult patients and helps lower elevated blood pressure. GNH India supplies Inovum as a licensed, GDP-compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Menarini International Operations Luxembourg S.A.

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Indications & Clinical Uses

Inovum, a combination of an ARB and a calcium channel blocker, is indicated for the management of hypertension.

  • Hypertension (essential): lowers systolic and diastolic blood pressure in adults with primary hypertension.
  • Hypertension (insufficient control with monotherapy): provides additional blood pressure reduction when single‑agent therapy does not achieve target.
  • Hypertension (with cardiovascular risk): contributes to overall risk management in patients with hypertension and additional cardiovascular risk factors.

How It Works

  • Olmesartan medoxomil selectively blocks AT1 receptors, preventing angiotensin II‑mediated vasoconstriction and aldosterone release, while amlodipine inhibits L‑type calcium channels in vascular smooth muscle, causing vasodilation. The combined actions reduce systemic vascular resistance and lower arterial pressure.

Side Effects

Common Side Effects

  • Dizziness or light‑headedness.
  • Headache.
  • Peripheral edema, especially of the ankles.
  • Flushing or warmth sensation.
  • Fatigue.
  • Palpitations.

Serious or Rare Side Effects

  • Angioedema involving face, lips, tongue, or airway.
  • Severe hypotension.
  • Significant renal impairment or sudden rise in serum creatinine.
  • Hepatic dysfunction with elevated transaminases.
  • Neutropenia or other blood dyscrasias.
  • Severe allergic reactions such as Stevens‑Johnson syndrome.

Precautions & Warnings

Inovum should be used with caution and under medical supervision.

  • Monitor blood pressure regularly: adjust therapy if target values are not reached.
  • Assess renal function before initiation and periodically thereafter.
  • Avoid use in pregnancy: classified as Category D due to fetal risk.
  • Use cautiously in hepatic impairment: dose adjustment may be required.
  • Review concomitant potassium‑sparing agents: risk of hyperkalaemia.
  • Store at room temperature: keep in the original pack, protect from moisture and light.

Avoid Interactions

Inovum may interact with several medicines.

Major Interactions (Avoid)

  • ACE inhibitors or other ARBs: increased risk of renal impairment and hyperkalaemia.
  • Potassium‑sparing diuretics (e.g., spironolactone): may cause dangerous hyperkalaemia.
  • Strong CYP3A4 inhibitors (e.g., itraconazole, clarithromycin): raise amlodipine levels, leading to hypotension.

Moderate Interactions (Monitor Closely)

  • NSAIDs: may blunt the antihypertensive effect of Inovum.
  • Simvastatin or other CYP3A4 substrates: increased statin concentrations raise the risk of myopathy.

Frequently Asked Questions

Inovum is a prescription medication that combines olmesartan medoxomil, an angiotensin II receptor blocker, with amlodipine, a calcium‑channel blocker. The fixed‑dose combination is indicated for the treatment of hypertension in adults, helping to lower elevated systolic and diastolic blood pressure and reduce the risk of cardiovascular complications associated with high blood pressure.

Olmesartan medoxomil selectively blocks the AT1 receptors for angiotensin II, preventing the peptide from causing vasoconstriction, aldosterone release, and sympathetic activation. By inhibiting this pathway, it promotes vasodilation and reduces fluid retention, which together lower systemic vascular resistance and arterial pressure.

The specific dose of Inovum is determined by the prescribing clinician based on the patient’s blood‑pressure readings, previous therapy, and overall health status. The prescriber selects the appropriate strength and titrates as needed to achieve target blood‑pressure goals while monitoring for efficacy and safety.

Inovum is classified as pregnancy category D, indicating evidence of risk to the fetus and that it should be avoided unless the potential benefit justifies the risk. It is also not recommended during breastfeeding because the active ingredients can pass into breast milk and may affect the infant. Alternative therapies are preferred for pregnant or nursing women.

To place an order, visit the product page for Inovum on the GNH India website (gnhindia.com), enter the required quantity, and submit the enquiry form. GNH India works with hospitals, pharmacies, and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details, and any necessary import documentation.

Inovum offers the convenience of a single tablet that combines an ARB with a calcium‑channel blocker, which can improve adherence compared with taking two separate medications. Compared with monotherapy, the combination provides greater blood‑pressure reduction and may be more effective in patients whose pressure is not controlled on a single agent. It shares a similar safety profile to its individual components, but the fixed‑dose may limit dose flexibility.

Inovum tablets should be stored at room temperature, below 25 °C, in their original packaging to protect them from moisture and light. Keep the container tightly closed and out of reach of children. Do not store in bathrooms or near heat sources, and discard any tablets that appear discoloured or damaged.

Inovum is taken orally, usually once daily, with or without food, as directed by a healthcare professional. The tablet should be swallowed whole with a glass of water and not chewed, crushed, or split unless the prescriber specifically advises otherwise. Consistent daily dosing helps maintain stable blood‑pressure control.

The most serious adverse reactions to Inovum include severe hypotension, angioedema, and significant renal impairment, especially when used with other drugs that affect the renin‑angiotensin system or potassium balance. Patients should be monitored for sudden drops in blood pressure, swelling of the face or throat, and changes in kidney function, and seek immediate medical attention if these occur.

Inovum is contraindicated in individuals with known hypersensitivity to olmesartan, amlodipine, or any excipients in the formulation. It should also be avoided in patients with severe hepatic impairment, those who are pregnant, and anyone currently receiving an ACE inhibitor or another ARB. Patients with a history of angioedema or significant renal dysfunction should discuss alternative treatments with their physician.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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