Product image of Inoxgen (Nitric Oxide) supplied by GNH India

Inoxgen

Active Ingredient:
Nitric Oxide
Origin:
EU

Inoxgen (Nitric Oxide)

Nitric Oxide, the active ingredient in Inoxgen, is a vasodilator presented as a medical gas for endotracheopulmonary use. It provides selective pulmonary vasodilation to manage neonatal pulmonary hypertension and acute respiratory distress syndrome in newborns and critically ill patients requiring respiratory support. The therapy aims to improve oxygenation and reduce right‑ventricular strain.

GNH India supplies Inoxgen as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide. Our distribution network ensures timely delivery and regulatory compliance across multiple regions.

Manufacturer / TM Owner

Nippon Gases Deutschland Gmbh

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Indications & Clinical Uses

Inoxgen, a selective pulmonary vasodilator, is used in conditions characterized by elevated pulmonary vascular resistance.

  • Neonatal pulmonary hypertension: reduces pulmonary arterial pressure and improves oxygenation.
  • Acute respiratory distress syndrome: facilitates pulmonary vasodilation to support ventilation and oxygen exchange.
  • Right ventricular overload (secondary to pulmonary hypertension): lowers pulmonary artery pressure, alleviating right‑ventricular strain.

How It Works

  • Nitric Oxide diffuses into pulmonary vascular smooth‑muscle cells where it activates soluble guanylate cyclase. This activation raises intracellular cyclic GMP levels, leading to relaxation of smooth‑muscle fibers and selective dilation of pulmonary vessels while having minimal systemic vasodilatory effect.

Side Effects

Inoxgen may cause a range of adverse reactions, most of which are related to its vasodilatory and oxidative properties.

Common Side Effects

  • Hypotension: transient drop in systemic blood pressure.
  • Methemoglobinemia: elevated methemoglobin levels reducing oxygen delivery.
  • Rebound pulmonary hypertension: worsening pulmonary pressure after abrupt discontinuation.
  • Headache: mild to moderate intensity.
  • Nausea: occasional gastrointestinal upset.
  • Dizziness: sensation of light‑headedness.

Serious or Rare Side Effects

  • Severe hypotension: profound blood pressure decline requiring intervention.
  • Pulmonary hemorrhage: bleeding within the lung tissue.
  • Severe methemoglobinemia: high methemoglobin levels causing cyanosis.
  • Allergic reaction: rash, itching, or anaphylaxis.
  • Toxicity from accumulation: especially in patients with impaired clearance.
  • Infection related to delivery system: contamination of gas lines or cylinders.

Precautions & Warnings

When using Inoxgen, clinicians should observe several safety measures to minimize risk.

  • Monitor blood pressure: watch for systemic hypotension during and after administration.
  • Assess methemoglobin levels: periodic testing to detect methemoglobinemia.
  • Use specialized delivery equipment: ensure proper gas flow and concentration control.
  • Avoid concurrent potent vasodilators: combined effects may cause severe hypotension.
  • Contraindicated in known hypersensitivity: discontinue if allergic reaction occurs.
  • Store at ambient temperature: keep cylinders in a well‑ventilated, dry area away from heat sources.

Avoid Interactions

Inoxgen can interact with other agents that affect vascular tone or hemoglobin oxidation.

Major Interactions (Avoid)

  • Sildenafil or other phosphodiesterase‑5 inhibitors: may cause profound hypotension.
  • Methylene blue: reduces nitric oxide efficacy.
  • Inhaled anesthetics with cardiovascular depression: increase risk of hypotension.

Moderate Interactions (Monitor Closely)

  • Nitrates: additive vasodilatory effect requiring blood pressure monitoring.
  • Certain antibiotics (e.g., sulfonamides): increase risk of methemoglobinemia.
  • Inhaled corticosteroids: may alter response to nitric oxide therapy.
  • Anticoagulants: monitor for bleeding if pulmonary hemorrhage occurs.

Frequently Asked Questions

Inoxgen is a medical‑gas formulation of nitric oxide used to provide selective pulmonary vasodilation in newborns with pulmonary hypertension and in patients with acute respiratory distress syndrome. It helps lower pulmonary arterial pressure and improve oxygenation during critical respiratory support.

Nitric oxide released from Inoxgen diffuses into the smooth‑muscle cells of the pulmonary vasculature, where it activates soluble guanylate cyclase. This raises cyclic GMP levels, causing relaxation of the smooth‑muscle fibers and resulting in selective dilation of pulmonary vessels while sparing systemic circulation.

The dosage of Inoxgen is determined by the prescribing clinician based on the patient’s weight, severity of pulmonary hypertension, and response to therapy. Administration is typically titrated to achieve a target pulmonary arterial pressure and is adjusted according to continuous monitoring.

Safety data for Inoxgen in pregnant or breastfeeding individuals are limited. Use is generally reserved for critical neonatal or adult respiratory conditions where benefits outweigh potential risks, and it should be prescribed only after careful consideration by a qualified healthcare professional.

To order Inoxgen, submit an enquiry on the product page at gnhindia.com with the required quantity. GNH India supplies hospitals, pharmacies, and procurement teams worldwide, and will request trade or institutional credentials before providing pricing, availability, shipping details, and any necessary import documentation.

Inoxgen delivers inhaled nitric oxide directly to the lungs, providing rapid and selective pulmonary vasodilation with minimal systemic effects. Compared with systemic agents such as sildenafil, it offers a faster onset, precise titration, and reduced risk of systemic hypotension, though it requires specialized delivery equipment.

Inoxgen cylinders should be stored at ambient temperature in a well‑ventilated, dry area away from direct heat or flame. Keep the cylinders upright, protect the valve from damage, and ensure that only trained personnel handle the gas to maintain safety and product integrity.

Inoxgen is administered via endotracheopulmonary delivery using a calibrated inhalation system that mixes the gas with the patient’s ventilatory circuit. The concentration is continuously monitored, and adjustments are made based on real‑time measurements of pulmonary arterial pressure and oxygenation.

The most serious risks include severe hypotension, rebound pulmonary hypertension after abrupt discontinuation, and significant methemoglobinemia that can impair oxygen delivery. Prompt monitoring of blood pressure, methemoglobin levels, and careful weaning of therapy are essential to mitigate these risks.

Inoxgen should be avoided in patients with known hypersensitivity to nitric oxide, those with severe methemoglobinemia, or individuals receiving other potent vasodilators that could precipitate dangerous hypotension. Clinical judgment is required to assess suitability for each patient.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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