Product image of Inprosub (Progesterone) supplied by GNH India

Inprosub

Active Ingredient:
Progesterone
Origin:
EU

Inprosub (Progesterone)

Progesterone, the active ingredient in Inprosub, is a progestogen presented as an injectable solution for intramuscular, subcutaneous use. It treats hormonal deficiencies, supports luteal phase in assisted reproduction, prevents preterm birth, and is used in hormone replacement therapy.

GNH India supplies Inprosub as a licensed, GDP-compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Ibsa Farmaceutici Italia

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Indications & Clinical Uses

Progesterone, a progestogen, is used in several reproductive and hormonal indications.

  • Luteal phase support in assisted reproduction: enhances endometrial receptivity and improves implantation rates.
  • Prevention of preterm birth: reduces the risk of early delivery in high‑risk pregnancies.
  • Hormone replacement therapy: restores hormonal balance in menopausal or hypo‑estrogenic women.
  • Treatment of menstrual disorders: regulates the menstrual cycle and alleviates abnormal bleeding.

How It Works

  • Progesterone acts as an agonist at intracellular progesterone receptors, modulating gene transcription in target tissues. Receptor activation prepares the endometrium for implantation, maintains uterine quiescence during pregnancy, and exerts anti‑estrogenic effects on the breast and uterus. It also influences the hypothalamic‑pituitary‑gonadal axis, contributing to menstrual cycle regulation.

Side Effects

Progesterone injectable solution may be associated with several adverse reactions.

Common Side Effects

  • Injection site pain: mild to moderate discomfort at the injection site.
  • Local swelling or erythema: transient redness or swelling.
  • Nausea: occasional feeling of queasiness.
  • Headache: mild headache episodes.

Serious or Rare Side Effects

  • Thromboembolic events: rare clot formation.
  • Allergic reaction (including anaphylaxis): rash, itching, or severe hypersensitivity.
  • Hyperglycemia: elevated blood glucose levels.
  • Hepatic dysfunction: abnormal liver enzyme elevations.

Precautions & Warnings

When using Inprosub, consider the following precautions:

  • Patient assessment: evaluate history of thromboembolic disease before use.
  • Hormone‑sensitive conditions: avoid in active breast or endometrial cancer.
  • Diabetes monitoring: monitor blood glucose in diabetic patients.
  • Pregnancy status: confirm gestational age and risk factors prior to administration.
  • Store at 2-8°C: keep refrigerated, protect from light, do not freeze or shake.

Avoid Interactions

Progesterone may interact with several medications.

Major Interactions (Avoid)

  • Anticoagulants: may increase risk of bleeding.
  • CYP3A4 inducers: may reduce progesterone efficacy.
  • Hormonal contraceptives: additive progestogenic effects may cause hormonal imbalance.

Moderate Interactions (Monitor Closely)

  • Antidiabetic drugs: progesterone may affect glucose control.
  • Antihypertensives: possible fluid retention may alter blood pressure.
  • Antifungal azoles: may increase progesterone levels.

Frequently Asked Questions

Inprosub is a progesterone injectable solution used for luteal phase support in assisted reproduction, prevention of preterm birth in high‑risk pregnancies, hormone replacement therapy in menopausal or hypo‑estrogenic women, and treatment of certain menstrual disorders.

Progesterone binds to intracellular progesterone receptors, altering gene transcription. This prepares the uterine lining for embryo implantation, maintains uterine quiescence during pregnancy, and provides anti‑estrogenic effects that help regulate the menstrual cycle and support hormone replacement therapy.

The specific dose and dosing schedule of Inprosub are determined by the prescribing clinician based on the indication, patient characteristics, and treatment protocol. No fixed regimen is provided here.

Progesterone is used in certain pregnancy situations, such as luteal phase support and preterm‑birth prevention, but safety must be evaluated by the treating physician. Limited data are available for breastfeeding, and a clinician should assess risk versus benefit.

To order Inprosub, submit an enquiry on the product page at gnhindia.com specifying the required quantity. GNH India works with hospitals, pharmacies, and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details (including cold‑chain if needed) and import documentation.

Inprosub is an injectable progesterone formulation, offering rapid systemic exposure compared with oral micronized progesterone, which undergoes first‑pass metabolism. Injectable routes provide more consistent serum levels, which can be advantageous for luteal support and preterm‑birth prevention, while oral forms are more convenient but may have variable absorption.

Inprosub must be stored at 2‑8 °C in a refrigerator, protected from light. Do not freeze or shake the vial. Keep the product in its original packaging until use to maintain stability.

Inprosub is administered by a healthcare professional via intramuscular or subcutaneous injection, according to the prescribing information. The injection site and technique are selected based on the clinical protocol and patient tolerance.

Serious risks include rare thromboembolic events, severe allergic reactions such as anaphylaxis, hyperglycemia, and hepatic dysfunction. Patients should be monitored for signs of clotting, hypersensitivity, abnormal liver tests, or significant changes in blood glucose.

Inprosub should be avoided in individuals with known hypersensitivity to progesterone, active breast or endometrial cancer, uncontrolled thromboembolic disorders, and in patients where hormonal therapy is contraindicated. A clinician must evaluate each patient’s medical history before prescribing.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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