Inprosub (Progesterone)

Progesterone, as delivered by Inprosub, is used in several hormone‑related therapeutic pathways.

• Hormone replacement therapy (HRT): provides progestogenic support to counterbalance estrogen and protect the endometrium in postmenopausal women.
• Luteal phase support in assisted reproductive technology: maintains a receptive endometrial lining to improve implantation rates after embryo transfer.
• Prevention of preterm birth in high‑risk pregnancies: reduces the incidence of early labor in women with a short cervix or prior preterm delivery.

• Progesterone binds intracellular progesterone receptors, forming a hormone‑receptor complex that translocates to the nucleus and regulates gene transcription. This modulation promotes secretory transformation of the endometrium, stabilizes the uterine lining, and suppresses gonadotropin release, thereby supporting pregnancy maintenance and counteracting estrogen‑induced proliferation. It also influences the expression of enzymes involved in prostaglandin synthesis, contributing to reduced uterine contractility. Additionally, progesterone exerts immunomodulatory effects that help maintain fetal tolerance.

Progesterone administered via Inprosub may be associated with a range of adverse reactions.

Common Side Effects

• Injection site pain
• Redness or swelling at the injection site
• Headache
• Nausea
• Breast tenderness

Serious or Rare Side Effects

• Thromboembolic events (deep vein thrombosis, pulmonary embolism)
• Severe allergic reaction or anaphylaxis
• Hyperglycemia or worsening diabetes control
• Hepatic dysfunction or jaundice

When prescribing Inprosub, clinicians should consider several safety precautions.

• Assess thromboembolic risk: evaluate history of clotting disorders before use.
• Monitor blood pressure: progesterone can influence vascular tone.
• Avoid in known hypersensitivity: discontinue if allergic reaction occurs.
• Use caution in hepatic impairment: adjust therapy if liver function is compromised.
• Consider pregnancy status: weigh benefits against potential fetal effects.
• Store at ambient temperature: keep in original container, protect from moisture and light.

Progesterone can interact with other medicines, affecting efficacy or safety.

Major Interactions (Avoid)

• Anticoagulants (e.g., warfarin): increased risk of bleeding.
• Hormonal contraceptives: may alter combined hormone levels.
• CYP3A4 inducers (e.g., rifampin): reduce progesterone effectiveness.
• CYP3A4 inhibitors (e.g., ketoconazole): raise progesterone concentrations.
• Estrogen therapy: heightened risk of thromboembolic events.

Moderate Interactions (Monitor Closely)

• Antidiabetic agents: progesterone may affect glucose control.
• Corticosteroids: potential additive effect on adrenal axis.
• Lithium: monitor serum lithium levels.
• Phenobarbital: may diminish progesterone action.
• SSRIs: possible mood alterations.