Product image of Inprosub (Progesterone) supplied by GNH India

Inprosub

Active Ingredient:
Progesterone
Origin:
EU

Inprosub (Progesterone)

Progesterone, the active ingredient in Inprosub, is a Progestogen presented as a subcutaneous formulation for subcutaneous use. It is employed in hormone therapy to support progesterone levels in appropriate patient populations.

GNH India supplies Inprosub as a licensed, GDP-compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Ibsa Farmaceutici Italia

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Indications & Clinical Uses

  • Progesterone is a progestogen that acts on the reproductive hormone pathway and is employed in several therapeutic areas.
  • Luteal phase support in assisted reproductive technology: helps maintain the uterine lining for embryo implantation.
  • Hormone replacement therapy in menopausal women: provides progesterone to counterbalance estrogen effects.
  • Prevention of preterm birth in women with a short cervix: reduces the risk of early delivery.

How It Works

  • Progesterone binds to intracellular progesterone receptors, forming a hormone‑receptor complex that translocates to the nucleus and regulates gene transcription. This action prepares the endometrium for implantation, stabilises the uterine lining, and modulates the hypothalamic‑pituitary‑gonadal axis, thereby influencing menstrual cycles and supporting pregnancy.

Side Effects

Progesterone therapy may be associated with a range of adverse reactions.

Common Side Effects

  • Injection site pain or erythema
  • Headache
  • Nausea or vomiting
  • Breast tenderness
  • Mood swings or irritability
  • Fluid retention

Serious or Rare Side Effects

  • Allergic reaction or anaphylaxis
  • Thromboembolic events (deep vein thrombosis, pulmonary embolism)
  • Severe depression or mood disorders
  • Hepatic dysfunction
  • Severe hypertension
  • Adrenal insufficiency

Precautions & Warnings

  • Progesterone therapy requires careful patient assessment and monitoring.
  • Assess indication: confirm that progesterone supplementation is clinically appropriate.
  • Monitor thromboembolic risk: evaluate history of clotting disorders before initiation.
  • Observe for allergic reactions: discontinue if signs of hypersensitivity appear.
  • Evaluate liver function: use with caution in patients with hepatic impairment.
  • Review concomitant hormone therapy: adjust doses to avoid excess estrogen exposure.
  • Store at 2-8°C: keep refrigerated, protect from light, do not freeze or shake.

Avoid Interactions

Progesterone can interact with several drug classes, necessitating vigilance.

Major Interactions (Avoid)

  • Combined estrogen‑progestogen therapy: increased risk of thromboembolic events.
  • CYP450 inducers (e.g., rifampin): may reduce progesterone plasma levels.
  • Antifungal azoles (e.g., ketoconazole): may increase progesterone concentrations.

Moderate Interactions (Monitor Closely)

  • Antidepressants (SSRIs): may alter mood-related side effects.
  • Antihypertensives: progesterone may affect blood pressure control.
  • Diuretics: potential impact on fluid balance and electrolyte status.

Frequently Asked Questions

Inprosub contains progesterone and is used in hormone replacement therapy for menopausal women, as luteal phase support in assisted reproductive technology, and to reduce the risk of preterm birth in pregnant women with a short cervix. The specific indication is determined by the prescribing clinician based on the patient’s medical condition.

Progesterone acts as an agonist at intracellular progesterone receptors. After binding, the hormone‑receptor complex moves into the cell nucleus and regulates the transcription of genes involved in preparing the endometrium for implantation, maintaining pregnancy, and modulating the menstrual cycle. These actions support the hormonal balance required for the therapeutic goals of Inprosub.

The dosage of Inprosub is individualized. A qualified prescriber determines the amount, frequency, and duration of treatment based on the patient’s indication, weight, and clinical response. No standard dosing regimen is provided here; the prescribing information must be consulted for precise guidance.

Progesterone is a natural hormone of pregnancy, and Inprosub may be prescribed when the benefits outweigh potential risks. However, safety data for breastfeeding are limited, and the decision should be made by a healthcare professional after evaluating maternal and infant health. It is not recommended for use without medical supervision in these populations.

To order Inprosub, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India supplies hospitals, pharmacies, and procurement teams worldwide. After the request, the sales team will verify trade or institutional credentials, then provide pricing, availability, shipping details (including cold‑chain logistics if needed), and required import documentation.

Inprosub is a subcutaneous injectable formulation, offering rapid and consistent absorption compared with oral micronized progesterone, which can have variable bioavailability due to first‑pass metabolism. Injectable progesterone provides more reliable serum levels for luteal support and preterm‑birth prevention, while oral forms are often used for chronic hormone replacement but may require higher doses.

Inprosub should be stored at 2‑8 °C (refrigerated). Keep the vials in their original packaging, protect them from light, and avoid freezing or shaking the product. If refrigeration is unavailable for a short period, the product may remain at controlled room temperature for up to 24 hours, but it should be returned to the recommended temperature as soon as possible.

Inprosub is administered by subcutaneous injection, typically into the abdomen or thigh. The injection should be performed by a qualified healthcare professional using aseptic technique. The exact injection site, volume, and frequency are dictated by the prescribing clinician’s instructions and the therapeutic indication.

Serious risks include allergic reactions such as anaphylaxis, thromboembolic events (deep‑vein thrombosis, pulmonary embolism), severe depression or mood disorders, hepatic dysfunction, and severe hypertension. Patients should be monitored closely for signs of these conditions, and therapy should be discontinued immediately if any serious adverse reaction occurs.

Inprosub is contraindicated in individuals with known hypersensitivity to progesterone or any excipients, those with active or uncontrolled thromboembolic disease, severe liver impairment, or unexplained vaginal bleeding. Pregnant or breastfeeding women should only use it under direct medical supervision, and patients with a history of hormone‑sensitive cancers should avoid it unless specifically indicated by a specialist.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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