Product image of Inspra (Eplerenone) supplied by GNH India

Inspra

Active Ingredient:
Eplerenone
Origin:
EU

Inspra (Eplerenone)

Eplerenone, the active ingredient in Inspra, is an aldosterone antagonist presented as an oral tablet for oral use. It is employed to manage high blood pressure, reduce the risk of cardiovascular events in patients with reduced‑ejection‑fraction heart failure, and improve outcomes after a myocardial infarction.

GNH India supplies Inspra as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide, adhering to stringent quality standards and providing reliable global distribution.

Manufacturer / TM Owner

Viatris Hellas Limited

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Indications & Clinical Uses

  • Eplerenone acts on the mineralocorticoid pathway to treat several cardiovascular conditions.
  • Hypertension: lowers blood pressure by reducing sodium and water retention.
  • Heart failure with reduced ejection fraction: improves survival and reduces hospitalizations by decreasing cardiac remodeling.
  • Post‑myocardial infarction: lowers the risk of cardiovascular death and heart failure when added to standard therapy.

How It Works

  • Eplerenone selectively blocks the mineralocorticoid (aldosterone) receptor in the distal nephron, preventing aldosterone‑mediated sodium reabsorption and potassium excretion. This antagonism reduces extracellular fluid volume, lowers blood pressure, and mitigates cardiac remodeling processes that contribute to heart failure progression.

Side Effects

Eplerenone may cause a range of adverse reactions, which are classified by frequency and severity.

Common Side Effects

  • Dizziness
  • Headache
  • Fatigue
  • Nausea
  • Diarrhoea
  • Abdominal pain

Serious or Rare Side Effects

  • Hyperkalaemia
  • Acute renal impairment
  • Severe allergic reactions (including angio‑edema)
  • Hepatic dysfunction
  • Gynecomastia
  • Life‑threatening arrhythmias

Precautions & Warnings

  • Before initiating therapy, clinicians should assess individual risk factors and monitor laboratory parameters.
  • Monitor potassium levels: regular blood tests are required to detect hyperkalaemia.
  • Assess renal function: adjust use in patients with impaired kidney function.
  • Avoid use with potassium‑sparing diuretics: increased risk of high potassium.
  • Caution in elderly: increased sensitivity to blood pressure changes.
  • Pregnancy and lactation: safety not established; use only if benefits outweigh risks.
  • Store at ambient temperature: keep in original container, protect from moisture and heat.

Avoid Interactions

Eplerenone interacts with several drug classes; some combinations should be avoided while others require close monitoring.

Major Interactions (Avoid)

  • Potassium supplements or potassium‑sparing diuretics: may cause dangerous hyperkalaemia.
  • ACE inhibitors or ARBs: combined use can increase potassium and renal risk.
  • Strong CYP3A4 inhibitors (e.g., itraconazole, clarithromycin): raise eplerenone levels.

Moderate Interactions (Monitor Closely)

  • NSAIDs: may reduce renal clearance and increase potassium.
  • Digoxin: monitor for toxicity due to altered electrolyte balance.
  • Lithium: monitor serum levels as potassium changes affect lithium clearance.

Frequently Asked Questions

Inspra contains eplerenone, an aldosterone antagonist indicated for the treatment of hypertension, for patients with heart failure with reduced ejection fraction, and as part of post‑myocardial infarction therapy to lower the risk of cardiovascular death and subsequent heart failure.

Eplerenone selectively blocks aldosterone receptors in the kidney, preventing sodium reabsorption and potassium loss. This leads to reduced fluid retention, lower blood pressure, and attenuation of the pathological cardiac remodeling that drives heart‑failure progression.

The appropriate dose of Inspra is determined by the prescribing clinician based on the patient’s condition, renal function, and potassium levels. Dosage may be started low and titrated as needed, following local prescribing guidelines.

Safety of eplerenone in pregnancy and lactation has not been established. It should only be used when the potential benefit justifies the potential risk to the fetus or infant, and the decision must be made by a qualified health professional.

To order Inspra, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India supplies hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Both drugs are aldosterone antagonists, but eplerenone (Inspra) is more selective for the mineralocorticoid receptor, resulting in fewer anti‑androgenic side effects such as gynecomastia. Spironolactone may be less expensive but has a broader hormonal activity profile.

Inspra tablets should be stored at ambient temperature, below 25 °C, in the original packaging to protect them from moisture and heat. Keep the product out of reach of children and avoid exposure to direct sunlight.

Inspra is taken orally, usually once daily. It can be swallowed with or without food, but patients should follow the specific instructions provided by their prescriber and maintain consistent timing each day.

The most serious risks include hyperkalaemia, which can lead to cardiac arrhythmias, acute renal impairment, severe allergic reactions such as angio‑edema, and, rarely, hepatic dysfunction. Regular monitoring of electrolytes and renal function is essential.

Inspra is contraindicated in patients with known hyperkalaemia, severe renal impairment (eGFR < 30 mL/min/1.73 m²), or those taking other potassium‑sparing agents without close supervision. It should also be avoided in individuals with a history of hypersensitivity to eplerenone.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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