Product image of Instanyl (Fentanyl) supplied by GNH India

Instanyl

Active Ingredient:
Fentanyl
Origin:
EU

Instanyl (Fentanyl)

Fentanyl, the active ingredient in Instanyl, is an opioid analgesic presented as a nasal spray for intranasal use. It provides rapid relief of breakthrough cancer pain and acute severe pain that requires a fast‑acting opioid in adult patients.

GNH India supplies Instanyl as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, oncology centres, pharmacies and clinics worldwide. The company adheres to EU GMP guidelines and provides regulatory support for cross‑border distribution. Our logistics network ensures timely delivery and temperature‑controlled handling where required.

Manufacturer / TM Owner

Istituto Gentili S.R.L

1
Pack/s
This product is added to your enquiry list

Request a Quote

Please fill out the form below and our team will get back to you shortly with pricing and further information.

A minimum order value applies. Our team will confirm the exact amount or quantity after reviewing your requirements.

Indications & Clinical Uses

  • Instanyl (fentanyl) is an opioid analgesic used for rapid relief of severe pain episodes.
  • Breakthrough cancer pain: provides fast analgesia for cancer patients experiencing episodic pain spikes.
  • Acute postoperative pain: delivers rapid pain control when oral opioids are unsuitable.
  • Severe trauma pain: offers immediate relief in emergency settings where quick onset is critical.
  • Procedural pain: used for short‑duration intense pain during minor procedures.

How It Works

  • Fentanyl is a high‑potency µ‑opioid receptor agonist. After intranasal absorption, it crosses the blood‑brain barrier and binds to µ‑receptors in the central nervous system, inhibiting nociceptive neurotransmission and reducing the perception of pain. Its lipophilicity enables rapid onset of action within minutes, providing swift analgesic effect. The drug’s metabolism primarily occurs via hepatic CYP3A4, producing inactive metabolites that are excreted renally.

Side Effects

Fentanyl nasal spray may cause a range of adverse reactions, varying from mild to severe.

Common Side Effects

  • Nausea: mild to moderate feeling of sickness.
  • Dizziness: transient light‑headedness.
  • Nasal irritation: discomfort or burning at the spray site.
  • Constipation: reduced bowel movements.

Serious or Rare Side Effects

  • Respiratory depression: slowed or shallow breathing that can be life‑threatening.
  • Severe hypotension: marked drop in blood pressure.
  • Allergic reaction: rash, itching, swelling, or anaphylaxis.

Precautions & Warnings

When prescribing Instanyl, clinicians should consider several safety precautions to minimize risk.

  • Patient selection: avoid use in opioid‑naïve individuals unless benefits outweigh risks.
  • Concomitant CNS depressants: limit use with benzodiazepines or alcohol due to additive respiratory depression.
  • Respiratory status: monitor closely in patients with compromised breathing or sleep‑apnea syndrome.
  • Dose titration: adjust to the lowest effective dose and reassess frequently.
  • Pregnancy and lactation: use only if essential; discuss potential risks with obstetric specialist.
  • Store at room temperature: keep below 25 °C, protect from moisture, and retain in original container.

Avoid Interactions

Fentanyl nasal spray can interact with other medicines, altering its effect or safety profile.

Major Interactions (Avoid)

  • CYP3A4 inhibitors: ketoconazole, ritonavir, or clarithromycin may increase fentanyl levels and risk of toxicity.
  • CNS depressants: combined use with benzodiazepines, barbiturates, or high‑dose alcohol can cause profound respiratory depression.
  • MAO inhibitors: concurrent use can precipitate severe hypotension or serotonin syndrome.

Moderate Interactions (Monitor Closely)

  • CYP3A4 inducers: rifampin or carbamazepine may reduce fentanyl efficacy.
  • Serotonergic agents: SSRIs or SNRIs may increase risk of serotonin syndrome.
  • Diuretics: may enhance hypotensive effects.

Frequently Asked Questions

Instanyl is a fentanyl‑based nasal spray indicated for the rapid relief of breakthrough cancer pain and acute severe pain that requires a fast‑acting opioid, such as postoperative or trauma‑related pain.

Fentanyl acts as a potent agonist at the µ‑opioid receptors in the central nervous system. By binding these receptors, it blocks pain signal transmission, producing strong analgesia within minutes after intranasal administration.

The prescribed dose of Instanyl is determined by the treating physician based on the patient’s pain severity, opioid tolerance, and clinical condition. Dosing instructions are individualized and should follow the prescriber’s guidance.

The safety of Instanyl in pregnancy or while breastfeeding has not been definitively established. It should be used only if the potential benefit justifies the potential risk, and a healthcare professional should be consulted.

To order Instanyl, submit an enquiry on the product page at gnhindia.com specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Instanyl delivers fentanyl via the nasal route, offering a faster onset than oral formulations and comparable speed to other intranasal or transmucosal opioids. Its potency and rapid absorption make it suitable for breakthrough pain, while dosing flexibility differs among products.

Instanyl should be stored at room temperature, below 25 °C, in its original packaging. Protect the device from moisture and direct sunlight, and keep it out of reach of children.

Instanyl is administered as a single spray into one nostril. The patient should remain upright for a few minutes after dosing to ensure optimal absorption, and avoid blowing the nose immediately after use.

The most serious risks include respiratory depression, severe hypotension, and potential allergic reactions such as anaphylaxis. These events require immediate medical attention and close monitoring, especially in opioid‑tolerant patients.

Instanyl is contraindicated in patients with known hypersensitivity to fentanyl or any component of the formulation, in those with severe respiratory insufficiency, and in individuals who are not opioid‑tolerant unless under strict medical supervision.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

Disclaimer

At GNH India, we aim to provide information that is expert-reviewed, accurate, and reliable. However, all content on this platform is intended for general informational purposes only and does not constitute professional medical advice, diagnosis, or treatment. While efforts are made to maintain accuracy and currency, the information may contain errors, omissions, or may not reflect the latest developments. Always consult a qualified healthcare professional regarding any medical concerns.

All product names, brand names, trademarks and registered trademarks displayed on this website are the property of their respective owners. This website and its operator are not affiliated with, endorsed by, or authorized by any such trade mark owners unless expressly stated. Any reference to product names or trademarks is made solely for descriptive and informational purposes. No commercial relationship, sponsorship, approval, or association with any trademark owner should be inferred. Information provided herein does not constitute promotion, advertising, or an offer for sale of any medicinal product and is intended solely for general informational purposes.

All trademarks and brand names displayed on this website are used strictly in accordance with the provisions of the Trade Marks Act, 1999, specifically Sections 30 and 30(1) governing fair use. Trademark ownership has been accurately attributed under the "Manufacturer/ TM Owner" section in compliance with statutory requirements.

Related Products

Other formulations containing Fentanyl

A

A
A

A
A

A
A

A

Browse all products →

Ordering Process

Simple, Secure, and Seamless

Learn how our streamlined ordering process guarantees fast, compliant, and reliable access to essential medicines worldwide.

Quote request form

01

Submit Quote Request Form

Tell us what medications you need by filling out our simple form and uploading a valid document.

Price estimate review

02

We Review & Send Estimate

Our licensed pharmacists will verify your details and provide you with a detailed cost estimate.

Secure payment

03

Confirm & Make Payment

Discuss any queries, approve the estimate, and complete your payment.

Worldwide delivery

04

Get Delivered

Your medicines, safely packed and delivered to your door or nearest airport — hassle-free.

Regulatory recognitions

Quality You Can Trust

Our internationally recognized certifications underscore our commitment to safety, quality, and excellence.

SGS GSDP Certification

GSDP Compliant from SGS

URS ISO 9001

URS ISO 9001 Certification

FDA Maharashtra

Licensed by FDA Maharashtra

IEC License DGFT

IEC License issued by DGFT