Product image of Instillagel (Chlorhexidine Gluconate, Lidocaine Hydrochloride) supplied by GNH India

Instillagel

Active Ingredient:
Chlorhexidine Gluconate, Lidocaine Hydrochloride
Origin:
EU

Instillagel (Chlorhexidine Gluconate, Lidocaine Hydrochloride)

Chlorhexidine Gluconate and Lidocaine Hydrochloride, the active ingredient in Instillagel, is an antiseptic and local anesthetic presented as a gel for urethral use. It provides antisepsis and analgesia during catheterisation and other urological procedures.

GNH India supplies Instillagel as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, transplant centres, oncology centres, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Farco-Pharma Gmbh

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Indications & Clinical Uses

  • Instillagel, containing an antiseptic and local anesthetic, is employed in the urological pathway for infection control and pain relief.
  • Urethral antisepsis prior to catheterisation: reduces bacterial colonisation and infection risk.
  • Urethral analgesia during diagnostic procedures: provides local pain relief to improve patient comfort.
  • Urethral analgesia during therapeutic procedures: enables tolerable insertion of instruments.
  • Urethral preparation for endoscopic examinations: facilitates smooth instrument passage.

How It Works

  • Chlorhexidine gluconate disrupts bacterial cell membranes by binding to phospholipids, leading to loss of integrity and cell death. Lidocaine hydrochloride blocks voltage‑gated sodium channels on peripheral nerves, preventing depolarisation and thereby delivering local analgesia. The combined action provides simultaneous antiseptic protection and pain relief within the urethra.

Side Effects

Instillagel may cause local and systemic adverse reactions.

Common Side Effects

  • Mild urethral irritation.
  • Transient burning sensation.
  • Local redness.
  • Mild headache.

Serious or Rare Side Effects

  • Allergic reaction (rash, angioedema).
  • Severe urethral inflammation.
  • Anaphylaxis.

Precautions & Warnings

  • Use Instillagel with attention to patient safety and handling.
  • Assess patient for known hypersensitivity: avoid use in individuals with documented allergy to chlorhexidine or lidocaine.
  • Avoid use in active urethral infection unless indicated: consider alternative antiseptic.
  • Do not exceed recommended volume: apply only as directed by healthcare professional.
  • Monitor for systemic lidocaine effects: observe for signs of CNS toxicity in prolonged exposure.
  • Store at room temperature: keep in original container, protect from moisture and direct sunlight.

Avoid Interactions

Instillagel can interact with other medicines; review patient medication list.

Major Interactions (Avoid)

  • Concurrent use with other local anesthetics: risk of cumulative lidocaine toxicity.

Moderate Interactions (Monitor Closely)

  • Beta‑blockers: may potentiate lidocaine cardiac effects.
  • CYP450 inhibitors (e.g., amiodarone): may increase lidocaine plasma levels.
  • Anticoagulants: chlorhexidine may increase bleeding risk if mucosal integrity is compromised.

Frequently Asked Questions

Instillagel is a sterile gel formulated for urethral use. It provides antiseptic protection and local analgesia during catheterisation, diagnostic endoscopy, and therapeutic urological procedures, helping to reduce infection risk and improve patient comfort.

Chlorhexidine gluconate kills bacteria by disrupting their cell membranes, while lidocaine blocks voltage‑gated sodium channels on nerve endings, preventing pain signal transmission. The combination offers simultaneous antimicrobial action and pain relief within the urethra.

The prescribed amount of Instillagel is determined by the treating clinician based on the specific procedure and patient needs. Healthcare professionals apply the gel according to institutional protocols and the product’s instructions for use.

Safety data for Instillagel in pregnancy and lactation are limited. It should only be used if the potential benefit justifies any possible risk to the fetus or infant, and the decision should be made by a qualified healthcare provider.

To order Instillagel, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Instillagel uniquely combines chlorhexidine, a broad‑spectrum antiseptic, with lidocaine, a local anesthetic, in a single gel. Many alternative products contain only an antiseptic or only a local anesthetic, requiring separate applications. This dual action can simplify preparation and improve patient comfort.

Instillagel should be stored at room temperature, below 25 °C, in its original sealed container. Protect the gel from moisture, direct sunlight and extreme temperatures to maintain its sterility and efficacy.

Instillagel is applied directly into the urethra using a sterile applicator or syringe as directed by the clinician. The gel is typically administered shortly before catheter insertion or endoscopic instrumentation to provide antisepsis and analgesia.

Serious risks include allergic reactions such as rash, angioedema, or anaphylaxis, and severe urethral inflammation. Systemic lidocaine toxicity, though rare, can occur if excessive amounts are absorbed, leading to neurological or cardiovascular symptoms.

Instillagel should be avoided in patients with a known hypersensitivity to chlorhexidine, lidocaine, or any component of the formulation. It is also contraindicated in individuals with active severe urethral infection unless specifically advised by a healthcare professional.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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