Product image of Instillagel (Chlorhexidine Gluconate, Lidocaine Hydrochloride) supplied by GNH India

Instillagel

Active Ingredient:
Chlorhexidine Gluconate, Lidocaine Hydrochloride
Origin:
EU

Instillagel (Chlorhexidine Gluconate, Lidocaine Hydrochloride)

Chlorhexidine gluconate and lidocaine hydrochloride, the active ingredients in Instillagel, are an antiseptic and a local anesthetic presented as a gel for urethral use. They provide antimicrobial protection and pain relief during catheterisation and other urethral procedures in adult patients.

GNH India supplies Instillagel as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals worldwide. With a focus on safety and efficacy, the company supports clinical teams with timely product availability, technical support, and reliable distribution across multiple regions.

Manufacturer / TM Owner

Farco-Pharma Gmbh

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Indications & Clinical Uses

  • Instillagel is used in the urinary tract to provide antiseptic protection and local analgesia during invasive procedures.
  • Urinary catheterisation: reduces the risk of infection by delivering broad‑spectrum antimicrobial activity.
  • Urethral instrumentation: provides rapid local anesthesia to minimise patient discomfort.
  • Urethral surgery: offers both infection prophylaxis and analgesia during operative manipulation.

How It Works

  • Chlorhexidine gluconate disrupts bacterial cell membranes by binding to phospholipids, leading to leakage of intracellular contents and cell death. Lidocaine hydrochloride blocks voltage‑gated sodium channels in peripheral nerves, preventing depolarisation and thereby producing reversible local anaesthesia. The combined actions give simultaneous antimicrobial effect and pain relief at the site of urethral application.

Side Effects

Instillagel may cause local reactions at the application site.

Common Side Effects

  • Burning or stinging sensation during or after application.
  • Mild urethral irritation or redness.
  • Transient dysuria (painful urination).
  • Local swelling or edema.
  • Minor allergic skin reaction (rash or itching).
  • Temporary alteration of urine colour.

Serious or Rare Side Effects

  • Anaphylactic reaction (difficulty breathing, swelling of face or throat).
  • Severe chemical urethritis with intense pain.
  • Systemic lidocaine toxicity (dizziness, tinnitus, seizures) if absorbed in large amounts.
  • Significant tissue necrosis at the application site.
  • Persistent urinary retention requiring medical intervention.
  • Unexplained fever or systemic infection after use.

Precautions & Warnings

  • Before using Instillagel, consider the following safety measures.
  • Allergy assessment: avoid if the patient has known hypersensitivity to chlorhexidine or lidocaine.
  • Pregnancy: use only when the benefit outweighs potential risk; data are limited.
  • Breastfeeding: exercise caution as minimal systemic absorption may occur.
  • Urethral injury: do not apply to damaged or ulcerated mucosa.
  • Concurrent antiseptics: avoid mixing with other chlorhexidine‑containing products to reduce irritation risk.
  • Store at below 25°C: keep in the original container, protect from moisture and heat.

Avoid Interactions

Instillagel can interact with certain medications; monitor as indicated.

Major Interactions (Avoid)

  • Systemic local anesthetics: additive toxicity may increase risk of lidocaine‑related adverse effects.
  • Other chlorhexidine‑containing products: may cause excessive local irritation.
  • Prolonged catheter use with Instillagel: could promote bacterial resistance.

Moderate Interactions (Monitor Closely)

  • Anticoagulants: heightened bleeding risk if mucosal injury occurs.
  • Beta‑blockers: may enhance systemic lidocaine effects.
  • Renal impairment: monitor for increased systemic absorption and toxicity.

Frequently Asked Questions

Instillagel is a sterile gel containing chlorhexidine gluconate and lidocaine hydrochloride that is applied to the urethra. It provides antimicrobial protection to reduce urinary tract infection risk during catheterisation and delivers local anaesthesia to lessen pain during urethral instrumentation or surgery.

Chlorhexidine gluconate acts as a broad‑spectrum antiseptic by binding to bacterial cell membranes, disrupting their integrity and causing leakage of intracellular components. This rapid bactericidal activity helps prevent colonisation of the urethra during catheter insertion and other invasive procedures.

The dose of Instillagel is determined by the prescribing clinician based on the specific procedure and patient characteristics. Typically, a measured amount of gel is instilled into the urethra immediately before catheter placement or instrumentation, following the healthcare provider’s instructions.

Safety data for Instillagel in pregnancy and lactation are limited. It should only be used when the expected benefit justifies any potential risk to the fetus or infant, and the decision should be made by the treating physician after evaluating the clinical situation.

To order Instillagel, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Instillagel combines a potent antiseptic (chlorhexidine) with a local anaesthetic (lidocaine), offering both infection control and pain relief in a single formulation. Some alternative products provide only antiseptic activity, requiring a separate analgesic, which may increase procedural steps and cost.

Instillagel should be stored at temperatures below 25 °C, in its original sealed container, protected from moisture and direct sunlight. Ensure the packaging remains intact, and avoid freezing the gel, as temperature extremes can affect its consistency and efficacy.

Instillagel is applied directly into the urethra using a sterile applicator or syringe as directed by the clinician. The gel is typically instilled immediately before catheter insertion or any urethral manipulation, allowing the active ingredients to coat the mucosa for antiseptic and analgesic effect.

The most serious risks include severe allergic reactions such as anaphylaxis, systemic lidocaine toxicity if large amounts are absorbed, and significant chemical urethritis leading to intense pain or tissue damage. Prompt medical attention is required if any signs of these reactions occur.

Instillagel should not be used in patients with known hypersensitivity to chlorhexidine, lidocaine, or any excipients in the formulation. It is also contraindicated in individuals with severe urethral injury, active ulceration, or those who are currently using other chlorhexidine‑based products in the same area.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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