Product image of Instillagel (Chlorhexidine Gluconate, Lidocaine Hydrochloride) supplied by GNH India

Instillagel

Active Ingredient:
Chlorhexidine Gluconate, Lidocaine Hydrochloride
Origin:
EU

Instillagel (Chlorhexidine Gluconate, Lidocaine Hydrochloride)

Chlorhexidine Gluconate and Lidocaine Hydrochloride, the active ingredient in Instillagel, is an antiseptic and local anesthetic presented as a gel for urethral use. It helps prevent bacterial infection and provides analgesia during urethral catheterisation and related procedures.

GNH India supplies Instillagel as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, transplant centres and clinics worldwide.

Manufacturer / TM Owner

Farco-Pharma Gmbh

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Indications & Clinical Uses

Instillagel combines an antiseptic and a local anaesthetic to protect the urethra and reduce discomfort during catheter‑related procedures.

  • Prevention of infection during urethral catheterisation: reduces bacterial colonisation of the urethral mucosa.
  • Local analgesia of the urethra: provides pain relief while the catheter is inserted or removed.
  • Urethral antisepsis prior to diagnostic or therapeutic procedures: maintains sterility of the urinary tract.

How It Works

  • Chlorhexidine gluconate binds to bacterial cell membranes, disrupting their integrity and causing cell death, while lidocaine hydrochloride blocks voltage‑gated sodium channels on peripheral nerves, preventing depolarisation and producing a reversible loss of sensation in the urethral mucosa.

Side Effects

Instillagel may cause local and systemic reactions, most of which are mild and transient.

Common Side Effects

  • Burning or stinging sensation at the application site.
  • Mild urethral irritation or discomfort.
  • Transient dysuria (painful urination).
  • Localised redness or erythema.
  • Headache.
  • Nausea.

Serious or Rare Side Effects

  • Anaphylactic reaction or severe hypersensitivity.
  • Significant urethral ulceration or necrosis.
  • Systemic toxicity from lidocaine (e.g., CNS symptoms, cardiac arrhythmia).
  • Persistent severe pain or swelling.
  • Severe allergic dermatitis.
  • Acute renal impairment secondary to systemic absorption (very rare).

Precautions & Warnings

Before using Instillagel, consider the following safety measures.

  • Allergy assessment: avoid if the patient has known hypersensitivity to chlorhexidine or lidocaine.
  • Pregnancy: use only if the anticipated benefit justifies potential risk to the fetus.
  • Breastfeeding: limited data; evaluate risk versus benefit.
  • Urethral trauma: do not apply to severely injured or inflamed urethral tissue.
  • Concomitant topical anesthetics: monitor for additive local‑anaesthetic effects.
  • Store at room temperature: keep in the original container, protect from moisture and direct heat.

Avoid Interactions

Instillagel may interact with other agents; awareness helps minimise risk.

Major Interactions (Avoid)

  • Concurrent use of other chlorhexidine‑containing products: may increase local irritation.
  • Systemic local anaesthetics (e.g., bupivacaine, ropivacaine): risk of additive lidocaine toxicity.

Moderate Interactions (Monitor Closely)

  • Anticoagulants (e.g., warfarin): monitor for bleeding if urethral trauma occurs.
  • Antihistamines: may mask early signs of allergic reaction.
  • Certain antibiotics (e.g., aminoglycosides): watch for enhanced nephrotoxicity if systemic absorption occurs.

Frequently Asked Questions

Instillagel is a sterile gel that combines chlorhexidine gluconate and lidocaine hydrochloride to provide both antiseptic protection and local analgesia for the urethra. It is commonly applied before urethral catheterisation, diagnostic cystoscopy, or any procedure that may irritate the urinary tract, helping to prevent infection and reduce patient discomfort.

Chlorhexidine gluconate acts as a broad‑spectrum antiseptic by binding to bacterial cell membranes, disrupting their structure and causing leakage of intracellular contents, which leads to cell death. This rapid antimicrobial action reduces the bacterial load on the urethral mucosa, lowering the risk of infection during invasive procedures.

The dose of Instillagel is determined by the prescribing clinician based on the specific procedure and patient needs. Typically, a measured amount of gel is instilled into the urethra immediately before catheter insertion or the intended intervention. Exact volume and frequency should follow the healthcare professional’s instructions.

Safety data for Instillagel in pregnancy and lactation are limited. It should only be used when the expected benefit outweighs any potential risk to the fetus or infant. Healthcare providers should evaluate each case individually and discuss possible concerns with the patient before administration.

To place an order, submit an enquiry on the product page at gnhindia.com, specifying the required quantity of Instillagel. GNH India works with hospitals, pharmacies, and procurement teams worldwide, and will request trade or institutional credentials. After verification, the team provides pricing, availability, shipping details (including any cold‑chain requirements), and assists with import documentation.

Instillagel uniquely combines a potent antiseptic (chlorhexidine) with a local anaesthetic (lidocaine) in a single gel, offering both infection control and pain relief. Many alternative products provide only antiseptic action or require a separate anaesthetic, which can increase procedural steps and cost. Instillagel’s dual action simplifies preparation and may improve patient comfort.

Instillagel should be stored at room temperature, preferably below 25 °C, in its original sealed container. Protect the gel from direct sunlight, excessive heat, and moisture. Do not freeze the product, and keep it out of reach of children. Check the label for the expiry date before use.

Instillagel is applied directly into the urethra using a sterile applicator or syringe as directed by the clinician. The gel is typically instilled shortly before catheter insertion or the planned procedure, allowing the lidocaine to provide local anaesthesia while the chlorhexidine exerts its antiseptic effect. Administration should be performed under aseptic conditions.

The most serious risks include severe allergic reactions such as anaphylaxis, significant urethral ulceration or necrosis, and systemic lidocaine toxicity, which can manifest as neurological or cardiac symptoms. Immediate medical attention is required if any signs of severe hypersensitivity, persistent pain, or systemic toxicity develop after application.

Instillagel should be avoided in patients with known hypersensitivity to chlorhexidine, lidocaine, or any component of the formulation. It is also contraindicated in individuals with severe urethral injury, active ulceration, or infection at the application site. Clinicians should assess each patient’s medical history before prescribing.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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