Product image of Instillagel (Chlorhexidine Gluconate, Methyl Parahydroxybenzoate, Propyl Parahydroxybenzoate, Lidocaine Hydrochlo) supplied by GNH India

Instillagel

Active Ingredient:
Chlorhexidine Gluconate, Methyl Parahydroxybenzoate, Propyl Parahydroxybenzoate, Lidocaine Hydrochlo
Origin:
EU

Instillagel (Chlorhexidine Gluconate, Methyl Parahydroxybenzoate, Propyl Parahydroxybenzoate, Lidocaine Hydrochlo)

Chlorhexidine gluconate, the active ingredient in Instillagel, is an antiseptic and local anesthetic presented as a gel for urethral use. It is combined with lidocaine hydrochloride and preservative agents to provide antimicrobial protection and temporary numbing during procedures such as catheter insertion.

GNH India supplies Instillagel as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, transplant centres and clinics worldwide. The company adheres to stringent quality standards and provides regulatory documentation for global distribution. Customers benefit from reliable supply chains and responsive technical support.

Manufacturer / TM Owner

Farco-Pharma Gmbh

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Indications & Clinical Uses

Instillagel is used as a urogenital antiseptic to reduce microbial contamination during urethral procedures.

  • Urethral antisepsis: reduces bacterial load in the urethra prior to instrumentation.
  • Catheterization: helps prevent urinary tract infection associated with catheter insertion.
  • Surgical preparation: provides local anesthesia and antisepsis during minor urological surgeries.

How It Works

  • Chlorhexidine gluconate disrupts bacterial cell membranes by binding to phospholipids, leading to leakage of intracellular contents and cell death. Lidocaine hydrochloride blocks voltage‑gated sodium channels on peripheral nerves, producing reversible loss of sensation. Methyl and propyl parahydroxybenzoate act as preservatives, maintaining product stability and sterility.

Side Effects

Instillagel may cause local and systemic adverse reactions.

Common Side Effects

  • Mild urethral irritation: transient burning or stinging sensation.
  • Localized discomfort: brief dysuria or feeling of fullness.
  • Minor allergic reaction: redness or mild swelling at the application site.

Serious or Rare Side Effects

  • Anaphylaxis: severe allergic response requiring immediate medical attention.
  • Urethral ulceration: deep tissue injury or necrosis.
  • Systemic lidocaine toxicity: symptoms such as dizziness, tinnitus, or cardiac arrhythmia.

Precautions & Warnings

Use of Instillagel requires careful consideration of patient safety.

  • Allergy assessment: verify no known hypersensitivity to chlorhexidine or lidocaine.
  • Infection status: avoid in active urethral infections unless directed by a clinician.
  • Application volume: apply only the prescribed amount to prevent excess exposure.
  • Systemic monitoring: watch for signs of lidocaine toxicity, especially in prolonged use.
  • Pregnancy and lactation: use only if the potential benefit justifies the potential risk.
  • Store at room temperature: keep in the original container, protect from light and moisture.

Avoid Interactions

Instillagel can interact with other medications, requiring attention to avoid adverse outcomes.

Major Interactions (Avoid)

  • Concurrent local anesthetics: may increase systemic lidocaine levels.
  • Systemic chlorhexidine preparations: risk of additive toxicity.
  • QT‑prolonging drugs: lidocaine may exacerbate cardiac conduction effects.

Moderate Interactions (Monitor Closely)

  • Beta‑blockers: may alter lidocaine metabolism.
  • Antifungal agents: potential additive mucosal irritation.
  • Renal impairment: monitor for accumulation of lidocaine.
  • Hepatic dysfunction: may affect clearance of lidocaine.

Frequently Asked Questions

Instillagel is a urethral gel that combines an antiseptic and a local anesthetic. It is applied before urological procedures such as catheter insertion or minor surgeries to reduce bacterial contamination and provide temporary numbness, helping to prevent infection and improve patient comfort.

Chlorhexidine gluconate acts by binding to bacterial cell membranes, disrupting their integrity and causing leakage of intracellular components, which leads to rapid bacterial death. This broad‑spectrum antimicrobial effect helps keep the urethral tract free of pathogenic microorganisms during procedures.

The exact amount of Instillagel to be applied is determined by the prescribing clinician based on the specific procedure and patient factors. Healthcare professionals follow institutional protocols to ensure the correct volume is used for effective antisepsis and anesthesia.

Safety data for Instillagel in pregnancy and lactation are limited. It should only be used when the potential benefit to the mother outweighs any possible risk to the fetus or infant, and the decision should be made by a qualified healthcare provider.

To order Instillagel, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India supplies hospitals, pharmacies and procurement teams worldwide, and will request trade or institutional credentials before providing pricing, availability, shipping details and any necessary import documentation.

Instillagel combines chlorhexidine, a high‑potency antiseptic, with lidocaine for local anesthesia, offering both antimicrobial protection and pain relief in a single formulation. Many alternative products provide only antisepsis or only anesthesia, requiring separate applications, whereas Instillagel streamlines the preparation process.

Instillagel should be stored at room temperature, below 25 °C, in its original sealed container. Protect the gel from direct sunlight, excessive heat and moisture to maintain its stability and efficacy throughout its shelf life.

Instillagel is applied directly into the urethra using a sterile applicator or syringe as directed by the clinician. The gel spreads along the urethral mucosa, providing antiseptic action and local anesthesia before instrumentation or surgery.

The most serious risks include severe allergic reactions such as anaphylaxis, urethral ulceration or necrosis, and systemic lidocaine toxicity, which can cause neurological or cardiac symptoms. Immediate medical attention is required if any of these serious adverse events occur.

Instillagel should not be used in patients with known hypersensitivity to chlorhexidine, lidocaine, or any of the preservative agents. It is also contraindicated in individuals with active urethral infections unless specifically advised by a healthcare professional.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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