Product image of Instillagel - Einmalspritze (Chlorhexidine Gluconate, Lidocaine Hydrochloride) supplied by GNH India

Instillagel - Einmalspritze

Active Ingredient:
Chlorhexidine Gluconate, Lidocaine Hydrochloride
Origin:
EU

Instillagel - Einmalspritze (Chlorhexidine Gluconate, Lidocaine Hydrochloride)

Chlorhexidine gluconate, the active ingredient in Instillagel - Einmalspritze, is an antiseptic; lidocaine hydrochloride is a local anesthetic presented as a gel in a single‑use syringe for urethral use. It provides antiseptic protection and local anaesthesia during catheterisation and other urethral procedures.

GNH India supplies Instillagel - Einmalspritze as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals and clinics worldwide.

Manufacturer / TM Owner

Farco-Pharma Gmbh

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Indications & Clinical Uses

Instillagel - Einmalspritze combines an antiseptic and a local anaesthetic for use in the urinary tract.

  • Prophylaxis of urinary tract infections during catheterisation: reduces bacterial colonisation of the urethra.
  • Local anaesthesia for urethral procedures: provides reversible loss of sensation to facilitate instrumentation.
  • Disinfection of the urethra prior to instrumentation: prepares the urethral mucosa for safe catheter or endoscopic entry.

How It Works

  • Chlorhexidine gluconate disrupts bacterial cell membranes, leading to loss of integrity and cell death, while lidocaine hydrochloride blocks voltage‑gated sodium channels in peripheral nerves, producing a reversible loss of sensation. The combined action provides both antimicrobial protection and local anaesthesia when applied to the urethral mucosa.

Side Effects

Instillagel - Einmalspritze may cause local or systemic reactions, although most patients tolerate it well.

Common Side Effects

  • Burning sensation: mild transient discomfort at the application site.
  • Stinging or itching: brief irritation of urethral mucosa.
  • Redness or mild inflammation: localized erythema that resolves spontaneously.

Serious or Rare Side Effects

  • Allergic reaction: urticaria, angioedema, or anaphylaxis requiring immediate medical attention.
  • Severe urethral irritation: persistent pain, ulceration, or bleeding.
  • Systemic toxicity: signs of lidocaine overdose such as dizziness, tinnitus, or cardiac arrhythmia (rare).

Precautions & Warnings

When using Instillagel - Einmalspritze, observe the following precautions to ensure safety and effectiveness.

  • Patient assessment: verify no known hypersensitivity to chlorhexidine, lidocaine, or related compounds.
  • Contraindications: avoid in patients with a history of severe allergic reactions to the ingredients.
  • Use in pregnancy: limit use to situations where benefit outweighs potential risk; consult obstetric guidance.
  • Use in breastfeeding: consider potential exposure to infant; discuss with healthcare provider.
  • Interaction with other urethral agents: do not combine with other antiseptics or anesthetics without professional advice.
  • Store at ambient temperature: keep in original packaging, protect from moisture and direct sunlight.

Avoid Interactions

Instillagel - Einmalspritze can interact with certain medications or substances; awareness of these interactions helps prevent adverse outcomes.

Major Interactions (Avoid)

  • Other local anesthetics: concurrent use may increase risk of systemic lidocaine toxicity.
  • Systemic chlorhexidine exposure: combined use may enhance irritation or allergic response.

Moderate Interactions (Monitor Closely)

  • Anticoagulants: urethral irritation may increase bleeding risk; monitor for hematuria.
  • Beta‑blockers: may potentiate lidocaine’s cardiac effects; observe heart rate and rhythm.
  • Certain antibiotics (e.g., aminoglycosides): potential additive nephrotoxicity in patients with compromised renal function.

Frequently Asked Questions

Instillagel - Einmalspritze is used to provide antiseptic protection and local anaesthesia of the urethra during catheterisation, urethral instrumentation, and other related procedures. It helps prevent urinary tract infections and reduces discomfort by disinfecting the mucosa and numbing the area.

Chlorhexidine gluconate acts by binding to bacterial cell membranes, disrupting their integrity and causing leakage of intracellular contents, which leads to cell death. This broad‑spectrum antimicrobial activity makes it effective for reducing bacterial colonisation on the urethral surface.

The dose of Instillagel - Einmalspritze is determined by the prescribing clinician based on the specific procedure and patient needs. The product is supplied in a single‑use syringe that delivers the appropriate volume for urethral application.

Safety data are limited; therefore, use during pregnancy or breastfeeding should only be considered when the expected benefit justifies any potential risk. Clinicians should evaluate each case individually and discuss possible effects with the patient.

To order, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India supplies hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details (including any cold‑chain requirements) and import documentation.

The most common alternative is povidone‑iodine solution combined with a separate local anaesthetic. Instillagel offers a single‑dose, ready‑to‑use gel that combines both antiseptic and anaesthetic functions, reducing preparation steps and potential incompatibility issues while delivering comparable antimicrobial efficacy.

Store the product at ambient temperature, preferably below 25 °C, in its original sealed packaging. Protect it from moisture, direct sunlight and extreme temperatures. Do not freeze or expose the syringe to mechanical shock before use.

The gel is supplied in a sterile, single‑use syringe. After proper aseptic preparation, the clinician instills the gel directly into the urethra using the syringe tip, allowing the solution to coat the mucosa before catheter insertion or other instrumentation.

Serious risks include allergic reactions such as urticaria, angioedema or anaphylaxis, severe urethral irritation leading to ulceration or bleeding, and rare systemic lidocaine toxicity presenting as dizziness, tinnitus, or cardiac arrhythmias. Immediate medical attention is required if any of these occur.

Patients with a known hypersensitivity to chlorhexidine, lidocaine, or any component of the formulation should avoid using the product. It is also contraindicated in individuals who have experienced severe allergic reactions to similar antiseptics or local anaesthetics.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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