Product image of Instillido (Lidocaine Hydrochloride) supplied by GNH India

Instillido

Active Ingredient:
Lidocaine Hydrochloride
Origin:
EU

Instillido (Lidocaine Hydrochloride)

Lidocaine Hydrochloride, the active ingredient in Instillido, is a Local anesthetic presented as a solution for urethral use. It provides temporary loss of sensation to facilitate procedures involving the urethra.
GNH India supplies Instillido as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals and clinics worldwide.

Manufacturer / TM Owner

Farco-Pharma Gmbh

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Indications & Clinical Uses

Lidocaine Hydrochloride is a local anesthetic used for urethral anesthesia.

  • Urethral anesthesia: provides temporary loss of sensation to enable pain‑free urethral examinations and interventions.
  • Urethral catheter insertion: reduces discomfort during catheter placement.
  • Cystoscopic procedures: facilitates a tolerable environment for bladder inspection via the urethra.

How It Works

  • Lidocaine Hydrochloride reversibly blocks voltage‑gated sodium channels on neuronal membranes, preventing the initiation and propagation of nerve impulses. By stabilizing the neuronal membrane, it inhibits the transmission of pain signals from the urethral mucosa, producing a localized anesthetic effect without affecting systemic nerve function.

Side Effects

Lidocaine Hydrochloride may cause a range of adverse reactions, most of which are mild and transient.

Common Side Effects

  • Burning or stinging sensation at the application site.
  • Mild local irritation or redness.
  • Transient numbness extending beyond the target area.
  • Urinary urgency or frequency.
  • Mild headache.
  • Dizziness.

Serious or Rare Side Effects

  • Allergic reaction (rash, swelling, bronchospasm).
  • Systemic toxicity (seizures, cardiac arrhythmia, hypotension).
  • Methemoglobinemia.
  • Severe hypotension.
  • Anaphylaxis.
  • Persistent numbness or motor weakness.

Precautions & Warnings

Before using Instillido, consider the following safety measures.

  • Allergy assessment: confirm no known hypersensitivity to lidocaine or amide‑type anesthetics.
  • Cardiac history: avoid in patients with significant conduction disorders or severe heart disease.
  • Liver function: use caution in severe hepatic impairment as metabolism may be reduced.
  • Concomitant local anesthetics: limit total dose to prevent cumulative toxicity.
  • Pediatric use: restrict to situations where the benefit outweighs risk and dosing is carefully calculated.
  • Store below 25°C: keep in the original container, protect from moisture and light.

Avoid Interactions

Lidocaine Hydrochloride can interact with other medications that affect sodium channels or hepatic metabolism.

Major Interactions (Avoid)

  • Class I antiarrhythmics (e.g., quinidine, procainamide): increase risk of cardiac toxicity.
  • Amiodarone: may potentiate lidocaine plasma levels.
  • Cimetidine: can reduce hepatic clearance, raising systemic exposure.

Moderate Interactions (Monitor Closely)

  • Other local anesthetics: cumulative dose may lead to systemic toxicity.
  • Beta‑blockers (e.g., propranolol): may enhance lidocaine's cardiac effects.
  • CYP3A4 inhibitors (e.g., erythromycin): modestly increase lidocaine concentrations.

Frequently Asked Questions

Instillido contains lidocaine hydrochloride and is used to provide local anesthesia of the urethra. It is applied before procedures such as catheter insertion, cystoscopy, or any intervention that may cause discomfort in the urethral tract, helping to achieve a pain‑free experience for the patient.

Lidocaine hydrochloride works by reversibly blocking voltage‑gated sodium channels on nerve fibers. This inhibition prevents the initiation and conduction of nerve impulses, thereby stopping pain signals from reaching the brain in the area where the drug is applied.

The specific dose of Instillido is determined by the prescribing clinician based on the procedure, patient size, and clinical judgment. Healthcare professionals calculate the appropriate amount to achieve effective urethral anesthesia while staying within safe exposure limits.

Safety data for lidocaine hydrochloride in pregnancy and lactation are limited. It should only be used if the potential benefit justifies any possible risk to the fetus or infant, and the decision should be made by a qualified healthcare provider after evaluating the individual situation.

To order Instillido, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies, and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details (including any cold‑chain requirements), and necessary import documentation.

Instillido delivers lidocaine, an amide‑type local anesthetic with rapid onset and moderate duration. Compared with ester‑type agents such as procaine, lidocaine generally offers a faster onset, longer analgesic effect, and a lower incidence of allergic reactions, making it a preferred choice for urethral procedures.

Instillido should be stored below 25 °C in its original packaging, protected from moisture and direct light. Keep the container tightly closed when not in use and avoid exposure to extreme temperatures to maintain product stability.

Instillido is administered directly into the urethra as a solution. The healthcare professional instills the prescribed volume using a sterile catheter or syringe, allowing the lidocaine to coat the urethral mucosa and produce localized anesthesia before the intended procedure.

The most serious risks include systemic lidocaine toxicity, which can manifest as seizures, cardiac arrhythmias, or severe hypotension, and allergic reactions that may progress to anaphylaxis. Prompt recognition and immediate medical intervention are essential if these events occur.

Instillido should be avoided in individuals with a known hypersensitivity to lidocaine or other amide‑type local anesthetics, patients with severe hepatic impairment, and those with significant cardiac conduction disorders unless the benefit outweighs the risk and close monitoring is possible.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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