Product image of Instillido (Lidocaine Hydrochloride) supplied by GNH India

Instillido

Active Ingredient:
Lidocaine Hydrochloride
Origin:
EU

Instillido (Lidocaine Hydrochloride)

Lidocaine Hydrochloride, the active ingredient in Instillido, is a local anesthetic presented as a solution for urethral use. It provides local anesthesia for urethral procedures in adult patients.

GNH India supplies Instillido as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, transplant centres, oncology centres, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Farco-Pharma Gmbh

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Indications & Clinical Uses

Instillido (lidocaine hydrochloride) is used to provide local anesthesia in the urethral tract.

  • Urethral catheterization: reduces discomfort by numbing the urethral mucosa.
  • Urethral endoscopy: enables pain‑free visualization of the urethral lumen.
  • Urethral dilation: facilitates smooth passage of dilators during therapeutic procedures.

How It Works

  • Lidocaine hydrochloride blocks voltage‑gated sodium channels on neuronal membranes, preventing the initiation and propagation of nerve impulses. By inhibiting sodium influx, it stabilizes the neuronal membrane and produces reversible loss of sensation in the area where it is applied, resulting in localized anesthesia without affecting systemic nerve function.

Side Effects

Common Side Effects

  • Burning sensation at the application site.
  • Mild local irritation or redness.
  • Transient numbness extending slightly beyond the target area.
  • Slight swelling of the urethral mucosa.
  • Temporary taste alteration if solution contacts oral cavity.

Serious or Rare Side Effects

  • Allergic reactions such as urticaria, angioedema, or anaphylaxis.
  • Systemic toxicity presenting as central nervous system symptoms (e.g., dizziness, seizures).
  • Cardiac arrhythmias or conduction disturbances.
  • Severe hypotension.
  • Respiratory depression in extreme overdose.

Precautions & Warnings

Instillido should be used with attention to patient history and administration technique.

  • Assess allergy: confirm no known hypersensitivity to lidocaine or other amide‑type anesthetics.
  • Limit volume: apply the minimum amount required to achieve adequate anesthesia.
  • Monitor systemic exposure: observe patients with hepatic impairment for signs of toxicity.
  • Avoid concurrent use with other local anesthetics: reduce risk of additive systemic effects.
  • Store at room temperature: keep in the original container, protect from moisture and light.

Avoid Interactions

Lidocaine may interact with several drug classes; monitoring is advised.

Major Interactions (Avoid)

  • Class I antiarrhythmic agents (e.g., quinidine, procainamide): can increase plasma lidocaine levels.
  • Strong CYP3A4 inhibitors (e.g., ketoconazole): may raise systemic exposure.
  • Other local anesthetics: risk of additive toxicity.

Moderate Interactions (Monitor Closely)

  • Beta‑blockers: may mask early signs of lidocaine toxicity.
  • Diuretics: can alter plasma concentration and renal clearance.
  • Calcium channel blockers: may enhance cardiac effects of lidocaine.

Frequently Asked Questions

Instillido contains lidocaine hydrochloride and is used to provide local anesthesia during urethral procedures such as catheterization, endoscopy, and dilation. By numbing the urethral mucosa, it helps reduce discomfort and facilitates smoother clinical interventions.

Lidocaine hydrochloride blocks voltage‑gated sodium channels on nerve membranes, preventing the influx of sodium ions that are required for the generation and propagation of action potentials. This inhibition stops nerve impulse transmission, producing a reversible loss of sensation in the treated area.

The appropriate dose of Instillido is determined by the prescribing clinician based on the specific procedure, patient characteristics, and the required depth of anesthesia. Healthcare professionals calculate the volume needed to achieve effective local anesthesia while minimizing systemic exposure.

Safety data for lidocaine hydrochloride in pregnancy and lactation are limited. The product should only be used if the potential benefit justifies any potential risk to the fetus or infant, and it should be prescribed by a qualified healthcare professional after careful assessment.

To order Instillido, submit an enquiry on the product page at gnhindia.com indicating the required quantity. GNH India works with hospitals, pharmacies, and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Instillido’s lidocaine hydrochloride is an amide‑type local anesthetic offering rapid onset and moderate duration of action. Compared with ester‑type anesthetics, lidocaine generally provides a longer anesthetic window and a lower incidence of allergic reactions, making it a common choice for urethral procedures.

Instillido should be stored at room temperature, below 25 °C, in its original packaging. Protect the product from moisture, direct sunlight, and extreme temperature fluctuations to maintain its stability and sterility until use.

Instillido is administered directly into the urethra using a sterile applicator or catheter. The clinician instills the recommended volume of the solution onto the urethral mucosa, allowing it to take effect within minutes before proceeding with the intended procedure.

Serious risks include systemic toxicity leading to central nervous system symptoms such as seizures, cardiac arrhythmias, and severe allergic reactions like anaphylaxis. Prompt recognition of these signs and immediate medical intervention are essential to mitigate adverse outcomes.

Instillido should be avoided in patients with a known hypersensitivity to lidocaine, other amide‑type local anesthetics, or any component of the formulation. Caution is also advised for individuals with severe hepatic impairment, significant cardiac conduction disorders, or those taking interacting medications listed under major interactions.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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