Product image of Instillido (Lidocaine Hydrochloride) supplied by GNH India

Instillido

Active Ingredient:
Lidocaine Hydrochloride
Origin:
EU

Instillido (Lidocaine Hydrochloride)

Lidocaine, the active ingredient in Instillido, is a local anesthetic presented as a sterile solution for urethral use. It provides a reversible blockade of nerve conduction, delivering rapid onset of numbness to facilitate diagnostic or therapeutic procedures involving the urethra, with a short duration suitable for outpatient settings.

GNH India supplies Instillido as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, transplant centres, oncology centres, pharmacies and clinics worldwide, ensuring quality‑controlled manufacturing and reliable global distribution.

Manufacturer / TM Owner

Farco-Pharma Gmbh

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Indications & Clinical Uses

  • Instillido (lidocaine) is used for urethral anesthesia, providing local pain relief during procedures affecting the urinary tract.
  • Urethral anesthesia for diagnostic procedures: enables painless cystoscopic examination.
  • Urethral anesthesia for therapeutic procedures: facilitates interventions such as urethral dilation or stent placement.
  • Urethral catheterization: reduces discomfort during catheter insertion.

How It Works

  • Lidocaine exerts its effect by reversibly binding to the intracellular portion of voltage‑gated sodium channels on neuronal membranes. This blocks the influx of sodium ions during depolarisation, preventing the generation and propagation of action potentials. The resulting inhibition of nerve impulse conduction produces a localized loss of sensation in the area where the drug is applied, with onset within minutes and duration of up to an hour.

Side Effects

Instillido may cause a range of adverse reactions, varying from mild to serious.

Common Side Effects

  • Burning sensation at the application site
  • Mild itching or erythema
  • Transient dizziness

Serious or Rare Side Effects

  • Allergic reaction including rash, swelling, or anaphylaxis
  • Cardiac arrhythmia or conduction disturbances
  • Seizures

Precautions & Warnings

  • When using Instillido, consider the following precautions to minimise risk.
  • Assess patient history for lidocaine allergy: avoid use in known hypersensitivity.
  • Use the lowest effective volume: limit exposure to the urethral mucosa.
  • Monitor cardiovascular status: be aware of potential arrhythmias in susceptible patients.
  • Avoid concurrent use with other local anesthetics unless directed: may increase systemic toxicity.
  • Store at room temperature: keep in original packaging, protect from moisture and direct sunlight.

Avoid Interactions

Instillido can interact with other medicines; review patient medication lists.

Major Interactions (Avoid)

  • Class I antiarrhythmic agents (e.g., quinidine, procainamide): may potentiate cardiotoxicity.
  • CYP3A4 inhibitors (e.g., ketoconazole): can increase systemic lidocaine levels.

Moderate Interactions (Monitor Closely)

  • Class II antiarrhythmics (e.g., beta‑blockers): may enhance bradycardic effects.
  • Other local anesthetics: cumulative toxicity risk.
  • Epinephrine‑containing solutions: may alter absorption rate.

Frequently Asked Questions

Instillido is a lidocaine hydrochloride solution intended for urethral anesthesia. It is applied directly to the urethral mucosa to provide rapid, localized numbness during diagnostic examinations, therapeutic interventions, or catheter placement involving the urinary tract.

Lidocaine works by reversibly binding to voltage‑gated sodium channels on nerve cells. This blocks sodium influx during depolarisation, preventing the generation and propagation of nerve impulses, which results in a temporary loss of sensation in the treated area.

The appropriate dose of Instillido is determined by the prescribing clinician based on the specific procedure, patient characteristics, and clinical setting. Healthcare professionals calculate the volume needed to achieve effective urethral anesthesia while minimizing systemic exposure.

Safety data for Instillido in pregnancy or lactation are limited. The product’s pregnancy category is listed as unknown, so clinicians should weigh potential benefits against risks and consider alternative options when treating pregnant or nursing patients.

To order Instillido, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies, and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any required import documentation.

Instillido delivers lidocaine, a widely used amide‑type local anesthetic known for rapid onset and moderate duration. Compared with ester‑type agents such as benzocaine, lidocaine generally offers a more predictable pharmacokinetic profile and lower risk of allergic reactions, making it a preferred choice for urethral procedures.

Instillido should be stored at room temperature, below 25 °C, in its original container. Protect the solution from moisture, direct sunlight, and extreme temperature fluctuations. Ensure the vial is sealed until use and discard any product that appears discoloured or contaminated.

Instillido is administered by instilling the prescribed volume of the sterile solution directly into the urethra using a suitable applicator or catheter. The procedure is performed by trained healthcare personnel, and the onset of anesthesia typically occurs within minutes.

The most serious risks include severe allergic reactions such as anaphylaxis, cardiac arrhythmias or conduction disturbances, and central nervous system toxicity leading to seizures. Prompt recognition and management of these events are essential, and patients should be monitored during and after administration.

Instillido should be avoided in individuals with a known hypersensitivity to lidocaine or other amide‑type local anesthetics. Patients with significant cardiac conduction abnormalities, uncontrolled epilepsy, or those receiving interacting medications listed under major interactions should also be evaluated carefully before use.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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