Product image of Instillido (Lidocaine Hydrochloride) supplied by GNH India

Instillido

Active Ingredient:
Lidocaine Hydrochloride
Origin:
EU

Instillido (Lidocaine Hydrochloride)

Lidocaine Hydrochloride, the active ingredient in Instillido, is a local anesthetic presented as a sterile solution for urethral use. It provides reversible nerve block to relieve discomfort during diagnostic or therapeutic procedures involving the urethra, as well as during catheter insertion or removal.

GNH India supplies Instillido as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, transplant centres, oncology centres and pharmacies worldwide. The company adheres to EU quality standards and provides reliable logistics for global distribution. Customers benefit from consistent product availability and regulatory compliance support.

Manufacturer / TM Owner

Farco-Pharma Gmbh

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Indications & Clinical Uses

Instillido, a lidocaine‑based local anesthetic, is used for urethral anesthesia to facilitate various urological procedures.

  • Urethral diagnostic procedures: provides local anesthesia to reduce pain and discomfort during cystoscopy or imaging studies.
  • Therapeutic urethral interventions: enables painless catheter insertion, removal, or dilation during treatment.
  • Urethral examinations: offers temporary numbness to improve patient tolerance during routine examinations.

How It Works

  • Lidocaine hydrochloride acts by reversibly binding to the intracellular portion of voltage‑gated sodium channels on neuronal membranes. This blockade prevents the rapid influx of sodium ions during depolarization, thereby inhibiting the generation and propagation of nerve impulses. The resulting loss of sensory transmission produces a localized anesthetic effect in the urethral mucosa without affecting surrounding muscular function.

Side Effects

Instillido may cause local or systemic adverse reactions, which are categorized by frequency and severity.

Common Side Effects

  • Burning or stinging at the urethral site.
  • Transient numbness of the urethral mucosa.
  • Mild urinary urgency.

Serious or Rare Side Effects

  • Allergic reactions such as rash, itching, or swelling.
  • Systemic toxicity with dizziness, tinnitus, or seizures.
  • Cardiac arrhythmias or severe hypotension.

Precautions & Warnings

When using Instillido, clinicians should observe several precautions to ensure patient safety and product integrity.

  • Allergy assessment: confirm no known hypersensitivity to lidocaine or other amide‑type local anesthetics.
  • Pregnancy: avoid unless clearly needed, as safety data are limited.
  • Breastfeeding: use with caution; lidocaine may be excreted in milk.
  • Concomitant CNS depressants: monitor for enhanced systemic toxicity.
  • Renal or hepatic impairment: consider dose adjustment or increased observation.
  • Store at ambient temperature: keep below 25 °C, protect from moisture and light in the original container.

Avoid Interactions

Lidocaine can interact with other medicines, altering its effect or increasing toxicity risk.

Major Interactions (Avoid)

  • Class I antiarrhythmic agents (e.g., quinidine, procainamide): may cause additive cardiotoxicity.
  • Amiodarone: increases plasma lidocaine concentrations.
  • Cimetidine: reduces hepatic metabolism, raising lidocaine levels.

Moderate Interactions (Monitor Closely)

  • Beta‑blockers: may enhance bradycardia.
  • Calcium channel blockers: potential additive cardiac effects.
  • Other local anesthetics: risk of cumulative toxicity.

Frequently Asked Questions

Instillido is a lidocaine‑based solution intended for urethral anesthesia. It is employed to numb the urethral mucosa during diagnostic procedures such as cystoscopy, therapeutic interventions like catheter insertion or removal, and routine urethral examinations, helping to reduce patient discomfort.

Lidocaine hydrochloride blocks voltage‑gated sodium channels on nerve cells, preventing the rapid influx of sodium that is required for depolarisation. This inhibition stops the generation and propagation of nerve impulses, producing a localized loss of sensation in the area where it is applied.

The dose of Instillido is determined by the prescribing clinician based on the specific procedure, patient characteristics, and clinical judgement. No fixed regimen is provided here; the prescriber will decide the appropriate volume and concentration for each individual case.

Safety data for lidocaine hydrochloride in pregnancy are limited, and the product should only be used when clearly needed. During breastfeeding, lidocaine may be excreted in milk, so caution is advised and the benefits should be weighed against potential risks.

To request Instillido, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Instillido contains lidocaine, an amide‑type local anesthetic with a rapid onset and moderate duration, which is widely used for urethral procedures. Compared with ester‑type agents, lidocaine generally offers a more predictable safety profile and fewer allergic reactions, making it a common first‑choice option.

Instillido should be stored at ambient temperature, preferably below 25 °C, in its original sealed container. Protect the product from moisture, direct sunlight and extreme temperature fluctuations to maintain its stability and sterility.

Instillido is administered directly into the urethra as a sterile solution. The prescriber instills the appropriate volume using a catheter or syringe, allowing the medication to coat the urethral mucosa and produce local anaesthesia before the intended procedure.

Serious risks include systemic lidocaine toxicity, which can manifest as dizziness, tinnitus, seizures, or cardiac arrhythmias, and severe allergic reactions such as rash, swelling, or anaphylaxis. Immediate medical attention is required if any of these symptoms occur.

Instillido should be avoided in patients with a known hypersensitivity to lidocaine or other amide‑type local anesthetics, in those with severe cardiac conduction disorders, and in individuals where the risk of systemic toxicity cannot be adequately monitored.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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