Product image of Insulatard Flexpen (Insulin Human) supplied by GNH India

Insulatard Flexpen

Active Ingredient:
Insulin Human
Origin:
EU

Insulatard Flexpen (Insulin Human)

Insulin human, the active ingredient in Insulatard Flexpen, is an intermediate‑acting insulin presented as an injectable solution (pen) for subcutaneous use. It is used to lower elevated blood glucose in patients with type 1 diabetes mellitus and type 2 diabetes mellitus, providing basal insulin coverage.

GNH India supplies Insulatard Flexpen as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide. The company adheres to EU quality standards and provides cold‑chain logistics to ensure product integrity during transport. Customers receive full regulatory documentation and batch traceability.

Manufacturer / TM Owner

Novo Nordisk A/S

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Indications & Clinical Uses

Insulatard Flexpen, an intermediate‑acting insulin, is employed in the management of diabetes mellitus and related hyperglycaemic conditions.

  • Type 1 diabetes mellitus: provides basal insulin to maintain fasting glucose levels.
  • Type 2 diabetes mellitus: complements oral agents to achieve overall glycaemic control.
  • Insulin‑deficient hyperglycaemia: stabilises blood glucose when endogenous insulin production is insufficient.

How It Works

  • Insulin human binds to insulin receptors on muscle, adipose and hepatic cells, activating the receptor’s tyrosine kinase activity. This promotes translocation of GLUT‑4 transporters, enhancing glucose uptake, and suppresses hepatic gluconeogenesis, thereby lowering circulating glucose concentrations and providing basal metabolic control.

Side Effects

Common Side Effects

  • Hypoglycaemia: low blood glucose episodes, especially if meals are missed or activity increases.
  • Injection site pain or erythema: mild discomfort at the subcutaneous injection site.
  • Weight gain: gradual increase due to improved glucose utilisation.
  • Lipodystrophy: localized fat tissue changes with repeated injections.

Serious or Rare Side Effects

  • Severe hypoglycaemia: profound low glucose requiring assistance.
  • Allergic reaction including anaphylaxis: rash, swelling, respiratory distress.
  • Insulin antibody formation: may alter insulin effectiveness and cause unpredictable glucose levels.

Precautions & Warnings

When using Insulatard Flexpen, consider the following precautions.

  • Dose individualisation: Adjust based on blood‑glucose monitoring and clinical response.
  • Hypoglycaemia risk: Educate patients to recognise and treat low blood sugar promptly.
  • Renal impairment: Use with caution; monitor glucose closely.
  • Pregnancy and lactation: Use only if benefits outweigh potential risks.
  • Drug interactions: Review concomitant medications that affect glucose homeostasis.
  • Store at 2-8°C: keep refrigerated, protect from light, do not freeze or shake.

Avoid Interactions

Insulatard Flexpen may interact with other medicines; monitor accordingly.

Major Interactions (Avoid)

  • Concurrent sulfonylureas: increased risk of hypoglycaemia.
  • Beta‑blockers: may mask typical hypoglycaemia symptoms.
  • Systemic corticosteroids: may necessitate higher insulin doses.

Moderate Interactions (Monitor Closely)

  • ACE inhibitors: can enhance insulin sensitivity, potentially lowering glucose.
  • Thiazide diuretics: may raise blood glucose levels.
  • Oral contraceptives: may affect insulin requirements.

Frequently Asked Questions

Insulatard Flexpen contains insulin human (NPH), an intermediate‑acting insulin used as basal therapy to control blood glucose in adults and children with type 1 diabetes mellitus and type 2 diabetes mellitus. It provides a steady insulin level between meals and overnight.

Insulin human mimics the action of natural pancreatic insulin. It binds to insulin receptors on muscle, fat and liver cells, stimulating glucose uptake and storage while inhibiting hepatic glucose production. This dual action reduces circulating glucose and supplies cells with energy.

The dose of Insulatard Flexpen is individualized. A qualified prescriber determines the amount, timing and frequency based on the patient’s blood‑glucose readings, diet, activity level and overall treatment plan. No standard regimen is provided in public information.

Insulin human is classified as a pregnancy‑category B drug in many regions, meaning it may be used when the potential benefit justifies the potential risk. Breastfeeding mothers should consult their healthcare provider, as insulin is present in small amounts in milk but is generally considered compatible with nursing.

To request Insulatard Flexpen, submit an enquiry on the product page at gnhindia.com indicating the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, cold‑chain shipping options and necessary import documentation.

Insulatard Flexpen (NPH) has a longer onset and duration than rapid‑acting insulins but a shorter and more variable profile than newer basal analogues such as insulin glargine or insulin detemir. NPH may require twice‑daily dosing, whereas analogues often allow once‑daily administration with a flatter glucose‑lowering curve.

Store the pen at 2‑8 °C (refrigerated) in its original carton, protected from light. Do not freeze or shake the pen. Once in use, it may be kept at controlled room temperature (up to 30 °C) for a maximum of 28 days, as specified in the product label.

Insulatard Flexpen is administered subcutaneously using the pre‑filled pen device. The injection site should be rotated among the abdomen, thigh or upper arm. Patients should follow the pen’s instructions for dose setting, needle attachment and disposal, and always inject into clean, dry skin.

The most serious risks include severe hypoglycaemia, which can cause loss of consciousness or seizures, and allergic reactions ranging from rash to anaphylaxis. Rarely, insulin antibodies may develop, altering insulin action and causing unpredictable glucose control.

Insulatard Flexpen is contraindicated in individuals with a known hypersensitivity to insulin human or any excipients in the formulation. Patients with severe hypoglycaemia unawareness or those who cannot reliably monitor blood glucose should use it only under close medical supervision.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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