Product image of Insulatard Innolet (Insulin Human) supplied by GNH India

Insulatard Innolet

Active Ingredient:
Insulin Human
Origin:
EU

Insulatard Innolet (Insulin Human)

Insulin human, the active ingredient in Insulatard Innolet, is an insulin presented as a 100 IU/mL solution for injection for subcutaneous use. It treats diabetes mellitus in both type 1 and type 2 patients.

GNH India supplies Insulatard Innolet as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Novo Nordisk A/S

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Indications & Clinical Uses

Insulatard Innolet, a long‑acting insulin, is used to manage blood glucose in diabetes mellitus.

  • Type 1 diabetes mellitus: provides basal insulin coverage to maintain fasting glucose levels.
  • Type 2 diabetes mellitus: complements oral agents or rapid‑acting insulin to achieve overall glycaemic control.
  • Hospitalised hyperglycaemia: supplies basal insulin for patients requiring stable glucose management during inpatient care.

How It Works

  • Insulin human binds to insulin receptors on muscle, adipose and hepatic cells, activating the receptor tyrosine kinase pathway. This stimulates glucose uptake and utilization, promotes glycogen synthesis, and suppresses hepatic gluconeogenesis. The NPH formulation contains protamine, which delays absorption and prolongs the insulin’s action, providing a basal insulin effect for up to 12–18 hours after subcutaneous injection.

Side Effects

Common Side Effects

  • Hypoglycaemia: low blood glucose episodes, especially if meals are missed or dosing is excessive.
  • Injection site reactions: redness, swelling, or itching at the injection site.
  • Weight gain: modest increase due to improved glucose utilisation.
  • Lipodystrophy: localized changes in subcutaneous fat with repeated injections.

Serious or Rare Side Effects

  • Severe hypoglycaemia with seizures or loss of consciousness.
  • Anaphylactic reaction: systemic allergic response requiring immediate medical attention.
  • Insulin antibodies: may alter insulin efficacy or cause hypersensitivity.
  • Stevens‑Johnson syndrome or toxic epidermal necrolysis: rare severe skin reactions.
  • Acute metabolic acidosis: very rare but potentially life‑threatening.

Precautions & Warnings

Before using Insulatard Innolet, consider the following precautions:

  • Dose adjustment: modify the dose in renal or hepatic impairment to avoid hypoglycaemia.
  • Blood‑glucose monitoring: check glucose levels frequently, especially when initiating therapy.
  • Hypoglycaemia unawareness: use caution in patients who cannot recognise low‑glucose symptoms.
  • Pregnancy and lactation: safety category is unknown; weigh benefits against potential risks.
  • Concomitant medications: review drugs that may potentiate or mask hypoglycaemia.
  • Store at 2-8°C: keep refrigerated, protect from light, do not freeze or shake the vial.

Avoid Interactions

Insulatard Innolet may interact with other medicines as follows:

Major Interactions (Avoid)

  • Sulfonylureas or meglitinides: combined use can cause severe hypoglycaemia.
  • Alcohol: may potentiate insulin’s glucose‑lowering effect and increase hypoglycaemia risk.
  • Beta‑blockers: can mask typical hypoglycaemia symptoms such as tachycardia.

Moderate Interactions (Monitor Closely)

  • Corticosteroids: may raise blood glucose, requiring insulin dose adjustments.
  • Thyroid hormones: can alter insulin requirements, necessitating close monitoring.
  • Diuretics (especially thiazides): may affect potassium levels and insulin sensitivity.
  • ACE inhibitors or ARBs: may influence potassium balance and require periodic checks.

Frequently Asked Questions

Insulatard Innolet is a long‑acting insulin formulation used to provide basal insulin coverage in patients with type 1 or type 2 diabetes mellitus. It helps maintain stable fasting blood‑glucose levels and is often combined with rapid‑acting insulins or oral antidiabetic agents for comprehensive glycaemic control.

Insulin human binds to insulin receptors on muscle, fat and liver cells, activating intracellular pathways that promote glucose uptake, glycogen synthesis and lipid storage while suppressing hepatic glucose production. The NPH (neutral protamine Hagedorn) component slows absorption, extending the insulin’s action to provide a basal effect for many hours after injection.

The dose of Insulatard Innolet is individualized and set by a qualified prescriber based on the patient’s blood‑glucose targets, body weight, diet, activity level and concurrent therapies. Patients should follow the dosing instructions provided by their healthcare professional and adjust only under medical supervision.

The pregnancy safety category for insulin human (NPH) is not definitively established. Insulin is generally considered the preferred glucose‑lowering therapy in pregnancy when needed, but the decision should be made by the treating obstetrician and endocrinologist after weighing potential benefits and risks. Breastfeeding mothers should also consult their physician.

To place an order, submit an enquiry on the product page at gnhindia.com specifying the required quantity of Insulatard Innolet. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details (including cold‑chain logistics) and any necessary import documentation.

Insulatard Innolet (NPH insulin) is a protamine‑combined formulation that offers a peak of action around 4‑12 hours and a duration of up to 18 hours, making it suitable for twice‑daily dosing. Compared with newer basal analogues such as glargine or degludec, NPH has a more pronounced peak and may require more frequent glucose monitoring, but it is often less expensive and widely available.

Insulatard Innolet should be stored in a refrigerator at 2‑8 °C, protected from light and kept in its original packaging. Do not freeze the product, and avoid shaking the vial. Once in use, the solution can be kept at room temperature (up to 25 °C) for a maximum of 28 days, after which any remaining product should be discarded.

Insulatard Innolet is administered by subcutaneous injection, typically into the abdomen, thigh or upper arm. The injection site should be rotated with each dose to reduce the risk of lipodystrophy. Patients should be trained by a healthcare professional on proper injection technique, needle length selection and disposal of used sharps.

The most serious risks include severe hypoglycaemia, which can lead to seizures, loss of consciousness or even death if not promptly treated, and rare allergic reactions such as anaphylaxis. Patients should be educated on recognising early signs of low blood glucose and have a rapid‑acting carbohydrate source readily available.

Insulatard Innolet should be avoided in individuals with a known hypersensitivity to insulin human, protamine or any excipients in the formulation. It is also contraindicated in patients with severe hypoglycaemia unawareness or those who cannot reliably monitor their blood glucose levels. Clinical judgment is required for patients with significant renal or hepatic impairment.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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