Product image of Insulatard Penfill (Insulin Human) supplied by GNH India

Insulatard Penfill

Active Ingredient:
Insulin Human
Origin:
EU

Insulatard Penfill (Insulin Human)

Insulin Human, the active ingredient in Insulatard Penfill, is an insulin presented as a pre‑filled pen for subcutaneous use. It is used to treat hyperglycaemia in people with type 1 diabetes mellitus and type 2 diabetes mellitus. Insulin Human works by replacing or supplementing the body’s natural insulin to help control blood glucose levels.

GNH India supplies Insulatard Penfill as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Novo Nordisk A/S

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Indications & Clinical Uses

Insulatard Penfill provides basal insulin therapy for diabetes management.

  • Type 1 diabetes mellitus: improves glycaemic control by supplying long‑acting insulin.
  • Type 2 diabetes mellitus: assists in achieving target fasting glucose levels when diet, exercise, or oral agents are insufficient.
  • Basal insulin therapy: offers steady insulin coverage to maintain fasting blood glucose between meals.

How It Works

  • Insulin Human binds to insulin receptors on muscle, adipose and hepatic cells, activating the receptor’s tyrosine kinase activity. This triggers intracellular signaling that promotes glucose uptake into peripheral tissues and suppresses hepatic glucose production, thereby lowering circulating blood glucose concentrations.

Side Effects

Common Side Effects

  • Hypoglycaemia: low blood sugar episodes, especially if meals are missed or dosing is excessive.
  • Injection site reactions: redness, swelling, or itching at the injection site.
  • Weight gain: increased appetite and caloric storage.
  • Lipodystrophy: localized thickening or thinning of subcutaneous fat.
  • Edema: mild fluid retention, often in the lower extremities.
  • Headache: transient mild headache.

Serious or Rare Side Effects

  • Severe allergic reaction: urticaria, angioedema, or anaphylaxis.
  • Hypokalemia: low potassium levels, potentially causing cardiac arrhythmias.
  • Insulin‑induced lipohypertrophy: large areas of fat accumulation.
  • Acute respiratory distress: rare but serious breathing difficulty.
  • Persistent hypoglycaemia: prolonged low blood glucose requiring medical intervention.
  • Vision changes: transient blurred vision during hypoglycaemic episodes.

Precautions & Warnings

Before using Insulatard Penfill, consider the following precautions:

  • Hypoglycaemia risk: monitor blood glucose regularly and adjust dose as needed.
  • Renal impairment: use lower doses and monitor kidney function.
  • Hepatic impairment: may require dose adjustments.
  • Pregnancy and lactation: discuss benefits and risks with a healthcare professional.
  • Concomitant medications: review all drugs for potential interactions.
  • Store at 2-8°C: keep refrigerated, protect from light, do not freeze or shake the pen.

Avoid Interactions

Insulatard Penfill may interact with several medications.

Major Interactions (Avoid)

  • Sulfonylureas or meglitinides: increased risk of severe hypoglycaemia.
  • Other insulin products: additive hypoglycaemic effect.
  • Beta‑adrenergic blockers: may mask hypoglycaemia symptoms.
  • MAO inhibitors: potential for unpredictable blood glucose changes.
  • Alcohol: can potentiate hypoglycaemia.

Moderate Interactions (Monitor Closely)

  • Thiazide diuretics: may raise blood glucose levels.
  • Corticosteroids: can increase insulin resistance.
  • Oral contraceptives: may alter insulin requirements.
  • ACE inhibitors: may enhance insulin sensitivity.
  • Lipid‑lowering agents (statins): possible modest effect on glucose control.

Frequently Asked Questions

Insulatard Penfill contains insulin human and is used as a basal insulin to help control blood glucose levels in people with type 1 or type 2 diabetes mellitus. It provides long‑acting insulin coverage to maintain fasting glucose between meals and overnight.

Insulin human binds to insulin receptors on muscle, fat and liver cells, activating a cascade that increases glucose uptake into cells and reduces glucose production by the liver. This combined action lowers circulating blood glucose and helps maintain metabolic balance.

The dose of Insulatard Penfill is individualized. A qualified prescriber determines the appropriate amount based on the patient’s blood glucose targets, body weight, diet, activity level and other medications. Patients should follow the prescribing healthcare professional’s instructions.

Insulin human is classified as pregnancy category B, indicating no evidence of risk in animal studies and limited human data. It may be used during pregnancy and lactation when the benefits outweigh potential risks, but treatment decisions should be made by a healthcare provider.

To order, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details (including cold‑chain if needed) and import documentation.

Insulatard Penfill delivers insulin human, a short‑acting analogue that provides a relatively flat, long‑duration profile. Compared with insulin glargine or detemir, it may have a slightly different onset and duration, but all serve the purpose of basal glucose control. Choice depends on patient response, dosing convenience and clinician preference.

Store the pen at 2‑8 °C (refrigerated) and protect it from light. Do not freeze or shake the pen. If needed, it can be kept at room temperature (up to 30 °C) for a maximum of 28 days, but should be returned to the refrigerator thereafter.

Insulatard Penfill is administered subcutaneously using the pre‑filled pen. The injection site can be the abdomen, thigh, buttock or upper arm. Patients should rotate sites to reduce lipodystrophy and follow the pen’s instructions for dose setting and injection technique.

The most serious risks include severe hypoglycaemia, which can cause loss of consciousness or seizures, and allergic reactions ranging from rash to anaphylaxis. Prompt recognition and treatment are essential, and patients should be educated on recognizing early signs.

Insulatard Penfill should not be used by individuals with a known hypersensitivity to insulin human or any excipients in the formulation. It is also contraindicated in cases of hypoglycaemia unawareness without proper monitoring and in patients where a rapid‑acting insulin is required instead of basal coverage.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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