Product image of Insulatard Penfill (Insulin Human) supplied by GNH India

Insulatard Penfill

Active Ingredient:
Insulin Human
Origin:
EU

Insulatard Penfill (Insulin Human)

Insulin Human, the active ingredient in Insulatard Penfill, is a insulin presented as a solution for injection (prefilled pen) for subcutaneous use. It treats type 1 and type 2 diabetes mellitus in patients who require basal insulin therapy.

GNH India supplies Insulatard Penfill as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Novo Nordisk A/S

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Indications & Clinical Uses

Insulatard Penfill provides long‑acting insulin to manage blood glucose in diabetes mellitus.

  • Type 1 diabetes mellitus: supplies basal insulin to maintain fasting glucose levels.
  • Type 2 diabetes mellitus: complements oral agents or other insulin regimens for glycaemic control.
  • Diabetes requiring basal insulin therapy: delivers steady insulin action to reduce hyperglycaemia between meals and overnight.

How It Works

  • Insulin Human binds to insulin receptors on cell membranes, activating the receptor’s intrinsic tyrosine kinase activity. This triggers downstream signaling pathways that promote translocation of GLUT‑4 transporters to the cell surface, enhancing glucose uptake in muscle and adipose tissue and suppressing hepatic glucose production, thereby lowering circulating blood glucose.

Side Effects

Common Side Effects

  • Hypoglycaemia: low blood sugar episodes, especially if dose is excessive.
  • Injection site reactions: redness, swelling, or itching at the injection site.
  • Weight gain: gradual increase in body weight with prolonged use.
  • Lipodystrophy: localized thickening or thinning of subcutaneous fat.

Serious or Rare Side Effects

  • Severe hypoglycaemia: can lead to loss of consciousness or seizures.
  • Allergic reactions: including anaphylaxis, urticaria, or angioedema.
  • Insulin antibody formation: may alter insulin effectiveness.
  • Hypokalemia: low potassium levels, particularly with rapid glucose shifts.
  • Skin necrosis: rare necrotic lesions at injection sites.

Precautions & Warnings

Precautions for Insulatard Penfill include careful monitoring and individualized dosing.

  • Dose adjustment: tailor insulin dose based on regular blood glucose measurements.
  • Hypoglycaemia risk: educate patients to recognise and treat low glucose promptly.
  • Renal impairment: consider dose reduction in patients with reduced kidney function.
  • Pregnancy: use only when benefits outweigh potential risks to the fetus.
  • Store at 2-8°C: keep refrigerated, protect from light, do not freeze or shake.

Avoid Interactions

Insulatard Penfill may interact with several drug classes.

Major Interactions (Avoid)

  • Beta‑blockers: can mask hypoglycaemia symptoms.
  • MAO inhibitors: may potentiate insulin’s glucose‑lowering effect.
  • Oral contraceptives: can increase insulin requirements.
  • Alcohol: may cause unpredictable glucose fluctuations.

Moderate Interactions (Monitor Closely)

  • Thiazide diuretics: may raise blood glucose levels.
  • Corticosteroids: can increase insulin needs.
  • ACE inhibitors: may enhance insulin sensitivity, requiring dose review.

Frequently Asked Questions

Insulatard Penfill is a prefilled insulin pen that provides long‑acting basal insulin to help control blood glucose in adults with type 1 or type 2 diabetes mellitus who require insulin therapy.

Insulin Human mimics the natural hormone insulin by binding to insulin receptors on cells, activating pathways that increase glucose uptake into muscle and fat and suppress glucose production by the liver, thereby lowering circulating blood sugar levels.

The dose of Insulatard Penfill is individualized. A qualified prescriber determines the appropriate amount based on the patient’s blood glucose readings, lifestyle, and overall treatment plan.

Insulin Human is classified as pregnancy category unknown. It may be used during pregnancy or lactation only if the potential benefit to the mother outweighs any possible risk to the fetus or infant, and under close medical supervision.

To order, submit an enquiry on the product page at gnhindia.com specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details (including cold‑chain if needed) and import documentation.

Insulatard Penfill contains human insulin, which has a pharmacokinetic profile similar to other long‑acting insulins but differs from analogues such as glargine or detemir in onset and duration. Choice of basal insulin depends on individual response, dosing convenience, and physician preference.

Store the pen at 2‑8 °C (refrigerated) in its original carton, protect it from light, and avoid freezing or shaking. Once in use, it may be kept at room temperature for up to the period indicated in the package insert.

Insulatard Penfill is administered subcutaneously using the prefilled pen. The injection site is typically the abdomen, thigh, or upper arm, rotating sites with each dose to reduce local reactions.

The most serious risks include severe hypoglycaemia, which can lead to loss of consciousness or seizures, and rare allergic reactions such as anaphylaxis. Prompt recognition and treatment are essential.

Patients with a known hypersensitivity to human insulin or any excipients in the formulation should avoid using Insulatard Penfill. It is also contraindicated in individuals experiencing severe hypoglycaemia until the condition is corrected.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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