Product image of Insuman Basal (Insulin Human) supplied by GNH India

Insuman Basal

Active Ingredient:
Insulin Human
Origin:
EU

Insuman Basal (Insulin Human)

Insulin Human, the active ingredient in Insuman Basal, is a long‑acting insulin presented as a 100 IU/mL injectable suspension for subcutaneous use. It treats diabetes mellitus in both type 1 and type 2 patients.

GNH India supplies Insuman Basal as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Sanofi-Aventis Deutschland Gmbh

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Indications & Clinical Uses

Insuman Basal is a long‑acting insulin used to manage blood glucose in diabetes mellitus.

  • Type 1 diabetes mellitus: provides basal insulin coverage to maintain stable glucose levels between meals and overnight.
  • Type 2 diabetes mellitus: complements oral agents or rapid‑acting insulins to achieve target glycemic control.
  • Gestational diabetes mellitus (when indicated): offers basal insulin support under specialist supervision.

How It Works

  • Insulin Human binds to insulin receptors on muscle, adipose and hepatic cells, activating the receptor’s intrinsic tyrosine kinase. This triggers intracellular signaling that promotes glucose uptake, glycogen synthesis and lipogenesis while suppressing hepatic gluconeogenesis, resulting in lowered plasma glucose concentrations.

Side Effects

Insuman Basal may cause a range of adverse reactions.

Common Side Effects

  • Hypoglycemia: low blood glucose episodes, especially if meals are missed or dosing is excessive.
  • Injection site reactions: redness, swelling or itching at the injection site.
  • Weight gain: modest increase in body weight due to improved glucose utilization.
  • Lipodystrophy: localized thickening or loss of subcutaneous fat.
  • Edema: mild fluid retention, often in the lower extremities.
  • Headache: transient mild to moderate headache.

Serious or Rare Side Effects

  • Severe hypoglycemia: profound low glucose requiring assistance.
  • Anaphylactic reaction: rare systemic allergic response with rash, bronchospasm or hypotension.
  • Insulin allergy: localized or systemic hypersensitivity to the protein.
  • Hypokalemia: low potassium levels, particularly with high insulin doses.
  • Acute pancreatitis: very rare inflammation of the pancreas.
  • Serum sickness–like reaction: fever, arthralgia and rash.

Precautions & Warnings

When using Insuman Basal, consider the following safety measures.

  • Dose titration: adjust dose based on regular glucose monitoring and clinical response.
  • Hypoglycemia risk: educate patients on recognizing and treating low blood glucose.
  • Renal impairment: monitor closely as insulin clearance may be reduced.
  • Pregnancy and lactation: use only if benefits outweigh potential risks and under specialist guidance.
  • Concomitant medications: review for agents that may mask hypoglycemia symptoms.
  • Store at 2-8°C: keep refrigerated, protect from light, do not freeze or shake.

Avoid Interactions

Insuman Basal can interact with several drug classes.

Major Interactions (Avoid)

  • Beta‑blockers: may mask hypoglycemia symptoms and prolong its duration.
  • Monoamine oxidase inhibitors (MAOIs): can potentiate insulin’s glucose‑lowering effect.
  • Corticosteroids: may increase insulin resistance, requiring dose adjustments.

Moderate Interactions (Monitor Closely)

  • Oral hypoglycemics (e.g., sulfonylureas, meglitinides): additive glucose‑lowering effect, risk of hypoglycemia.
  • Diuretics (thiazides): may impair glucose tolerance, necessitating closer monitoring.
  • ACE inhibitors: may enhance insulin sensitivity, modestly lowering glucose.

Frequently Asked Questions

Insuman Basal is a long‑acting insulin formulation used to provide basal glucose control in patients with type 1 or type 2 diabetes mellitus. It helps maintain stable blood glucose levels between meals and overnight, complementing rapid‑acting insulins or oral antidiabetic agents as part of a comprehensive diabetes management plan.

Insulin human mimics the action of natural human insulin by binding to insulin receptors on muscle, fat and liver cells. This binding activates intracellular pathways that increase glucose uptake, promote glycogen storage, and suppress hepatic glucose production, thereby lowering circulating blood glucose concentrations.

The dose of Insuman Basal is individualized. A qualified prescriber determines the appropriate amount based on the patient’s current glucose profile, body weight, renal function and other clinical factors. Patients should follow the dosing instructions provided by their healthcare professional and adjust only under medical supervision.

The safety of Insuman Basal in pregnancy and lactation has not been definitively established. It may be used when the expected benefit outweighs potential risks, and only under the guidance of an obstetrician or endocrinologist experienced in managing diabetes during pregnancy or while nursing.

To place an order, submit an enquiry on the product page at gnhindia.com specifying the required quantity. GNH India supplies hospitals, pharmacies and procurement teams worldwide. After verification of trade or institutional credentials, the sales team will provide pricing, availability, shipping details—including cold‑chain handling if needed—and assist with any required import documentation.

Insuman Basal contains insulin human, a recombinant human insulin, whereas many newer basal insulins are insulin analogues with modified amino‑acid sequences designed for flatter pharmacokinetic profiles. Both provide long‑duration glucose control, but analogue insulins may have reduced variability and lower nocturnal hypoglycemia risk. Choice depends on clinical response, cost considerations and prescriber preference.

Insuman Basal should be stored at 2‑8 °C (refrigerated) and protected from light. Do not freeze the vial or shake it vigorously. Once opened, the suspension can be kept at refrigerated temperature for up to 28 days, after which any remaining product should be discarded.

Insuman Basal is administered by subcutaneous injection, typically into the abdomen, thigh or upper arm. The injection should be given once daily at the same time each day, using a suitable insulin syringe or pen compatible with the vial. Proper injection technique and site rotation help minimize local reactions.

The most serious risks include severe hypoglycemia, which can cause loss of consciousness or seizures, and rare allergic reactions such as anaphylaxis. Patients should be educated on early signs of low blood glucose and instructed to seek immediate medical attention if they experience symptoms of a severe allergic response.

Insuman Basal is contraindicated in individuals with a known hypersensitivity to insulin human or any excipients in the formulation. It should also be avoided in patients with severe hypoglycemia unawareness unless closely supervised, and in those with acute insulin overdose until the condition is medically managed.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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