Product image of Insuman Basal (Insulin Human (Rdna)) supplied by GNH India

Insuman Basal

Active Ingredient:
Insulin Human (Rdna)
Origin:
EU

Insuman Basal (Insulin Human (Rdna))

Insulin human (rDNA), the active ingredient in Insuman Basal, is an insulin presented as a sterile solution for subcutaneous use. It mimics natural human insulin, providing basal glucose control for individuals with type 1 and type 2 diabetes mellitus, and is administered by injection according to a prescriber‑determined regimen.

GNH India supplies Insuman Basal as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide, offering reliable sourcing from the European market with adherence to quality standards.

Manufacturer / TM Owner

Sanofi-Aventis Deutschland Gmbh

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Indications & Clinical Uses

  • Insuman Basal is a basal insulin that acts on the endocrine system to regulate blood glucose levels in diabetes.
  • Type 1 diabetes mellitus: provides long‑acting insulin to maintain fasting glucose control.
  • Type 2 diabetes mellitus: added when basal insulin is required to achieve glycaemic targets.
  • Insulin deficiency states: supplements endogenous insulin in patients with inadequate pancreatic secretion.

How It Works

  • Insulin human (rDNA) binds to insulin receptors on muscle, adipose and hepatic cells, activating the receptor’s tyrosine kinase activity. This triggers intracellular signaling pathways that increase glucose uptake, promote glycogen synthesis, inhibit hepatic gluconeogenesis, and facilitate lipid synthesis, thereby lowering circulating blood glucose concentrations.

Side Effects

Insuman Basal may cause a range of adverse reactions.

Common Side Effects

  • Hypoglycaemia: low blood sugar episodes, especially if dose is excessive.
  • Injection‑site reactions: redness, swelling, or itching at the injection site.
  • Weight gain: modest increase associated with improved glucose utilization.
  • Lipodystrophy: localized fat accumulation or loss with repeated injections.
  • Edema: mild fluid retention, particularly in the lower extremities.
  • Headache: occasional mild headache.

Serious or Rare Side Effects

  • Severe hypoglycaemia: profound low glucose requiring assistance.
  • Anaphylactic reaction: rare but potentially life‑threatening allergy.
  • Allergic dermatitis: widespread skin rash or hives.
  • Insulin‑induced hypokalemia: low potassium levels in severe cases.
  • Acute insulin edema leading to cardiac decompensation.
  • Necrotising fasciitis at injection site (extremely rare).

Precautions & Warnings

  • When using Insuman Basal, consider the following precautions.
  • Dose adjustment: tailor the dose based on regular glucose monitoring and clinical response.
  • Hypoglycaemia risk: educate patients on recognising and treating low blood sugar.
  • Renal impairment: monitor kidney function and adjust dose if necessary.
  • Pregnancy and lactation: use only if benefits outweigh potential risks and under medical supervision.
  • Concomitant medications: review other drugs that may affect glucose levels or insulin action.
  • Store at 2-8°C: keep refrigerated, protect from light, do not freeze or shake.

Avoid Interactions

Insuman Basal can interact with several medicines; awareness helps maintain safety.

Major Interactions (Avoid)

  • Sulfonylureas or meglitinides: additive hypoglycaemia risk.
  • Beta‑blockers: may mask hypoglycaemia symptoms.
  • MAO inhibitors: unpredictable alterations in glucose control.

Moderate Interactions (Monitor Closely)

  • Thiazide diuretics: may raise blood glucose.
  • Systemic corticosteroids: can increase insulin requirements.
  • ACE inhibitors or ARBs: monitor renal function and potassium levels.

Frequently Asked Questions

Insuman Basal is a basal insulin formulation used to provide long‑acting glucose control in patients with type 1 or type 2 diabetes mellitus. It helps maintain stable fasting blood‑sugar levels when combined with meals and other diabetes therapies as directed by a healthcare professional.

Insulin human (rDNA) is a recombinant form of human insulin that binds to insulin receptors on muscle, fat and liver cells. This binding activates intracellular pathways that increase glucose uptake, promote glycogen storage, suppress hepatic glucose production, and facilitate lipid metabolism, thereby lowering blood glucose concentrations.

The dose of Insuman Basal is individualized. A prescriber determines the starting amount and any subsequent adjustments based on the patient’s blood‑glucose readings, body weight, diet, activity level and overall treatment plan. Patients should follow the specific dosing instructions provided by their healthcare provider.

Safety data for Insuman Basal in pregnancy and lactation are limited. It may be used during pregnancy only if the potential benefit justifies the potential risk to the fetus, and under close medical supervision. Breastfeeding mothers should consult their physician, as insulin does pass into breast milk in small amounts.

To order Insuman Basal, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details (including cold‑chain logistics) and any necessary import documentation.

Insuman Basal contains recombinant human insulin, whereas many newer basal insulins are insulin analogues with modified amino‑acid sequences that may offer flatter pharmacokinetic profiles. Both provide long‑acting glucose control, but analogue products can have a reduced risk of nocturnal hypoglycaemia in some patients. Choice depends on clinical response, cost, and prescriber preference.

Insuman Basal must be stored at 2‑8 °C (refrigerated) in its original packaging, protected from light. Do not freeze or shake the vial or pen. Once in use, it may be kept at room temperature (up to 30 °C) for a limited period as indicated in the product labeling, but should be discarded after the recommended time.

Insuman Basal is given by subcutaneous injection, typically into the abdomen, thigh or upper arm. The injection site should be rotated to avoid lipodystrophy. Patients should be trained on proper technique, needle length, and disposal of sharps, and should follow the dosing schedule prescribed by their healthcare professional.

The most serious risks include severe hypoglycaemia, which can cause loss of consciousness or seizures, and allergic reactions ranging from rash to anaphylaxis. Rarely, patients may develop insulin‑induced edema or hypokalemia. Prompt medical attention is required if any of these serious events occur.

Insuman Basal should not be used by individuals with a known hypersensitivity to human insulin or any excipients in the formulation. It is also contraindicated in patients experiencing severe hypoglycaemia unawareness or those with conditions that preclude insulin therapy without close medical supervision.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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