Product image of Insuman Basal Solostar (Insulin Human) supplied by GNH India

Insuman Basal Solostar

Active Ingredient:
Insulin Human
Origin:
EU

Insuman Basal Solostar (Insulin Human)

Insulin Human, the active ingredient in Insuman Basal Solostar, is an insulin presented as a 100 U/mL solution for injection (prefilled pen) for subcutaneous use. It provides basal insulin coverage to manage blood glucose in individuals with diabetes, including both type 1 and type 2 diabetes mellitus.

GNH India supplies Insuman Basal Solostar as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide. The company adheres to stringent quality standards and provides cold‑chain logistics for biologic products, ensuring product integrity from manufacture to delivery.

Manufacturer / TM Owner

Sanofi-Aventis Deutschland Gmbh

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Indications & Clinical Uses

Insuman Basal Solostar is a basal insulin that acts on the glucose regulation pathway in diabetes.

  • Type 1 diabetes mellitus: provides long‑acting insulin to maintain fasting glucose levels.
  • Type 2 diabetes mellitus: supplies basal insulin to complement oral agents and improve overall glycemic control.
  • Diabetes mellitus requiring basal insulin therapy: delivers steady insulin exposure to reduce hyperglycemia between meals and overnight.

How It Works

  • Insulin Human binds to insulin receptors on muscle, adipose and hepatic cells, activating the receptor tyrosine kinase cascade. This promotes translocation of GLUT‑4 transporters, increasing cellular glucose uptake, and suppresses hepatic gluconeogenesis, thereby lowering blood glucose. The formulation provides a prolonged, relatively flat pharmacokinetic profile that mimics endogenous basal insulin secretion. The subcutaneous administration allows gradual absorption, resulting in a duration of action of up to 24 hours, which supports once‑daily dosing.

Side Effects

Insuman Basal Solostar may be associated with several adverse reactions, ranging from mild to serious.

Common Side Effects

  • Hypoglycemia: low blood glucose episodes, especially if meals are missed or dosing is excessive.
  • Injection site reactions: redness, swelling, or itching at the injection site.
  • Weight gain: modest increase in body weight over time.

Serious or Rare Side Effects

  • Severe hypoglycemia: profound low glucose requiring assistance.
  • Allergic reactions: rash, urticaria, or angioedema indicating hypersensitivity.
  • Lipodystrophy: abnormal fat accumulation or loss at injection sites.
  • Insulin antibodies: formation of antibodies that may alter insulin action.

Precautions & Warnings

When using Insuman Basal Solostar, several precautions should be observed to ensure safety and effectiveness.

  • Hypoglycemia risk: monitor blood glucose frequently, especially during dose adjustments.
  • Dose titration: adjust gradually based on fasting glucose trends and physician guidance.
  • Concomitant medications: review other glucose‑lowering agents to avoid additive hypoglycemia.
  • Renal or hepatic impairment: assess function as insulin clearance may be altered.
  • Pregnancy and lactation: use only if benefits outweigh potential risks, after medical evaluation.
  • Store at 2-8°C: keep refrigerated, protect from light, do not freeze or shake.

Avoid Interactions

Insuman Basal Solostar can interact with other medicines, influencing glucose control or insulin activity.

Major Interactions (Avoid)

  • Sulfonylureas: combined use markedly increases hypoglycemia risk.
  • Beta‑blockers: may mask typical hypoglycemia symptoms, complicating detection.
  • Systemic corticosteroids: can raise blood glucose, potentially requiring higher insulin doses.

Moderate Interactions (Monitor Closely)

  • ACE inhibitors: may enhance insulin sensitivity, necessitating glucose monitoring.
  • Thiazide diuretics: can impair glucose tolerance, requiring dose review.

Frequently Asked Questions

Insuman Basal Solostar is a basal insulin indicated for the long‑term management of blood glucose in adults with type 1 or type 2 diabetes mellitus. It provides a steady insulin level to control fasting and between‑meal glucose, helping to achieve target glycemic goals as part of a comprehensive diabetes care plan.

Insulin Human mimics the action of naturally produced insulin by binding to insulin receptors on muscle, fat and liver cells. This triggers intracellular signaling that moves glucose‑transport proteins to the cell surface, increasing glucose uptake, while simultaneously suppressing liver glucose production, thereby lowering circulating blood sugar.

The dose of Insuman Basal Solostar is individualized. A qualified healthcare professional determines the starting amount and any subsequent adjustments based on the patient’s fasting glucose levels, overall treatment goals, body weight, renal function and other clinical factors. Patients should follow the prescriber’s written instructions precisely.

Data on the use of Insuman Basal Solostar in pregnancy and lactation are limited. It should be used only if the potential benefits to the mother outweigh any possible risks to the fetus or infant. Women who are pregnant, planning pregnancy, or breastfeeding must discuss treatment options with their obstetrician or endocrinologist.

To place an order, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, cold‑chain shipping details and any necessary import documentation.

Insuman Basal Solostar contains human insulin, offering a relatively flat, 24‑hour profile similar to other basal analogues such as insulin glargine or detemir. While analogues may have slightly longer duration or reduced variability, human basal insulin remains effective, is often less expensive, and is compatible with standard insulin pens.

Store the prefilled pen at 2‑8 °C (refrigerated) and protect it from light. Do not freeze or shake the pen. Once in use, it may be kept at controlled room temperature (up to 30 °C) for a maximum of 28 days, as indicated on the label.

The product is supplied as a prefilled pen for subcutaneous injection. Patients should select an appropriate injection site—typically the abdomen, thigh or upper arm—rotate sites with each dose, and follow the pen’s instructions for dose setting, needle attachment and disposal.

The most serious risks include severe hypoglycemia, which can cause loss of consciousness or seizures, and allergic reactions ranging from rash to anaphylaxis. Rarely, patients may develop lipodystrophy or insulin‑binding antibodies that alter insulin effectiveness. Prompt medical attention is required if any of these events occur.

Insuman Basal Solostar is contraindicated in individuals with a known hypersensitivity to insulin human or any of the pen’s excipients. Patients with severe hypoglycemia unawareness, uncontrolled adrenal or pituitary insufficiency, or those who are unable to monitor glucose levels appropriately should avoid its use until evaluated by a clinician.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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