Product image of Insuman Comb 15 (Insulin Human) supplied by GNH India

Insuman Comb 15

Active Ingredient:
Insulin Human
Origin:
EU

Insuman Comb 15 (Insulin Human)

Insulin Human, the active ingredient in Insuman Comb 15, is an insulin presented as an injectable solution for subcutaneous use. The product is manufactured to EU standards and is prescribed by healthcare professionals for glycemic control in type 1 and type 2 diabetes mellitus.

GNH India supplies Insuman Comb 15 as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Sanofi-Aventis Deutschland Gmbh

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Indications & Clinical Uses

  • Insuman Comb 15 is an insulin that acts on the endocrine pathway to manage diabetes mellitus.
  • Type 1 diabetes mellitus: provides basal and prandial insulin coverage to achieve target blood glucose levels.
  • Type 2 diabetes mellitus: supplements endogenous insulin to improve glycemic control when oral agents are insufficient.

How It Works

  • Insulin Human binds to insulin receptors on cell membranes, activating the receptor’s intrinsic tyrosine kinase activity. This triggers downstream signaling pathways that promote translocation of glucose transporter‑4 (GLUT‑4) to the cell surface, enhancing glucose uptake in muscle and adipose tissue while suppressing hepatic glucose production, thereby lowering circulating blood glucose concentrations.

Side Effects

Common Side Effects

  • Hypoglycemia: low blood glucose episodes, especially if meals are missed or dosing is excessive.
  • Injection site reactions: redness, swelling, or itching at the injection site.
  • Weight gain: increased adipose tissue due to improved glucose utilization.
  • Lipodystrophy: localized fat accumulation or loss at injection sites.
  • Edema: mild peripheral swelling.
  • Headache or fatigue.

Serious or Rare Side Effects

  • Severe hypoglycemia: neurological impairment requiring immediate treatment.
  • Allergic reactions: rash, urticaria, or anaphylaxis.
  • Insulin antibodies: may alter insulin effectiveness.
  • Severe hypokalemia: low potassium levels in rare cases.
  • Acute pancreatitis: sudden abdominal pain with elevated enzymes.
  • Vision changes: transient blurred vision associated with rapid glucose shifts.

Precautions & Warnings

  • Precautions for Insuman Comb 15 include careful monitoring and patient education.
  • Dose adjustment: tailor insulin dose based on frequent blood glucose measurements.
  • Hypoglycemia risk: educate patients on recognizing and treating low glucose episodes.
  • Pregnancy safety: Category B; use only if benefits outweigh potential risks.
  • Renal impairment: consider dose reduction and close monitoring.
  • Concomitant medications: assess for agents that may mask hypoglycemia symptoms.
  • Store at 2-8°C: keep refrigerated, protect from light, do not freeze or shake.

Avoid Interactions

Insuman Comb 15 may interact with several drug classes.

Major Interactions (Avoid)

  • Alcohol: can potentiate hypoglycemia, especially with fasting.
  • Beta‑blockers: may mask hypoglycemia symptoms, requiring closer glucose monitoring.
  • Sulfonylureas or meglitinides: additive risk of severe hypoglycemia.

Moderate Interactions (Monitor Closely)

  • Thiazolidinediones: may increase fluid retention, requiring weight monitoring.
  • ACE inhibitors or ARBs: may enhance insulin sensitivity, necessitating dose review.
  • Corticosteroids: can raise blood glucose, possibly requiring insulin dose increase.

Frequently Asked Questions

Insuman Comb 15 is a human insulin formulation used to lower blood glucose levels in patients with type 1 or type 2 diabetes mellitus. It provides both basal and prandial insulin activity to help achieve target glycemic control as part of a comprehensive diabetes management plan.

Insulin Human binds to insulin receptors on muscle, fat, and liver cells, activating intracellular signaling that moves glucose transporters to the cell surface. This increases glucose uptake from the bloodstream and reduces hepatic glucose production, thereby lowering circulating blood glucose concentrations.

The dose of Insuman Comb 15 is individualized and set by a qualified prescriber based on the patient’s blood glucose readings, dietary intake, activity level, and overall treatment goals. Patients should follow the dosing instructions provided by their healthcare professional.

Insuman Comb 15 is classified as Pregnancy Category B, indicating that animal studies have not shown risk but there are limited human data. It may be used during pregnancy or lactation only if the potential benefits justify the potential risks, and under close medical supervision.

To order Insuman Comb 15, submit an enquiry on the product page at gnhindia.com with the required quantity. GNH India works with hospitals, pharmacies, and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details (including cold‑chain logistics), and necessary import documentation.

Insuman Comb 15 contains human insulin, which has a similar efficacy profile to other recombinant human insulins but differs from insulin analogues that may have altered onset or duration of action. Choice of product depends on individual patient needs, dosing flexibility, and prescriber preference.

Insuman Comb 15 should be stored at 2‑8 °C (refrigerated) in its original carton, protected from light. Do not freeze or shake the vial. Once in use, the product may be kept at room temperature (up to 30 °C) for a limited period as indicated on the label.

Insuman Comb 15 is administered by subcutaneous injection into the abdomen, thigh, or upper arm. The injection technique, site rotation, and timing relative to meals should follow the prescribing clinician’s instructions to ensure optimal absorption and glycemic control.

The most serious risks include severe hypoglycemia, which can cause confusion, seizures, or loss of consciousness, and allergic reactions ranging from rash to anaphylaxis. Patients should be educated on early signs of hypoglycemia and instructed to seek immediate medical attention for any severe allergic symptoms.

Insuman Comb 15 should not be used by individuals with a known hypersensitivity to human insulin or any of the excipients in the formulation. It is also contraindicated in patients with severe hypoglycemia unawareness or those for whom insulin therapy is not indicated by their healthcare provider.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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