Product image of Insuman Comb 15 (Insulin Human) supplied by GNH India

Insuman Comb 15

Active Ingredient:
Insulin Human
Origin:
EU

Insuman Comb 15 (Insulin Human)

Insulin Human, the active ingredient in Insuman Comb 15, is an insulin presented as a subcutaneous preparation for subcutaneous use. It mimics natural pancreatic insulin to lower blood glucose, providing essential therapy for individuals with type 1 diabetes mellitus and type 2 diabetes mellitus who require exogenous insulin to achieve glycaemic control.

GNH India supplies Insuman Comb 15 as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide, ensuring reliable access to quality‑assured insulin for diabetes management across global markets.

Manufacturer / TM Owner

Sanofi-Aventis Deutschland Gmbh

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Indications & Clinical Uses

Insuman Comb 15, a human insulin, is used to manage blood glucose levels in diabetes mellitus.

  • Type 1 diabetes mellitus: provides basal and prandial insulin coverage to control fasting and post‑meal glucose levels.
  • Type 2 diabetes mellitus: improves glycaemic control when oral agents or other insulins are insufficient.
  • Hospitalised hyperglycaemia: used in acute settings to rapidly lower elevated blood glucose.

How It Works

  • Insuman Comb 15 contains insulin human, which binds to insulin receptors on cell membranes, activating the receptor’s intrinsic tyrosine kinase activity. This triggers intracellular signaling cascades that promote translocation of GLUT‑4 transporters to the cell surface, enhancing glucose uptake in muscle and adipose tissue, and suppressing hepatic gluconeogenesis, thereby reducing plasma glucose concentrations.

Side Effects

Insuman Comb 15 may cause a range of adverse reactions, from mild to severe.

Common Side Effects

  • Hypoglycaemia: low blood glucose episodes, especially if meals are missed or dose is excessive.
  • Injection site reactions: redness, swelling, or itching at the injection site.
  • Weight gain: increased caloric storage due to improved glucose utilization.
  • Edema: fluid retention, particularly in the lower extremities.
  • Lipodystrophy: changes in subcutaneous fat at repeated injection sites.

Serious or Rare Side Effects

  • Anaphylactic reaction: severe allergic response requiring immediate medical attention.
  • Severe hypoglycaemia with seizures or loss of consciousness.
  • Insulin antibody formation that may alter insulin activity.
  • Hypokalemia: low potassium levels, especially with high insulin doses.
  • Acute allergic dermatitis: widespread skin rash or hives.

Precautions & Warnings

When using Insuman Comb 15, several safety considerations are essential.

  • Blood glucose monitoring: adjust dose based on regular glucose readings.
  • Hypoglycaemia risk: educate patients on recognizing and treating low blood sugar.
  • Renal impairment: consider dose reduction as insulin clearance may be decreased.
  • Hepatic dysfunction: use caution, as altered metabolism can affect insulin action.
  • Concomitant beta‑blockers: may mask hypoglycaemia symptoms, requiring closer observation.
  • Store at 2-8°C: keep refrigerated, protect from light, do not freeze or shake.

Avoid Interactions

Insuman Comb 15 can interact with other medicines, influencing its efficacy or safety.

Major Interactions (Avoid)

  • Sulfonylureas or meglitinides: additive hypoglycaemia risk.
  • Beta‑blockers: may conceal hypoglycaemia warning signs.
  • Alcohol: can potentiate insulin‑induced hypoglycaemia.

Moderate Interactions (Monitor Closely)

  • Thiazide diuretics: may increase blood glucose levels.
  • Corticosteroids: can raise glucose, requiring dose adjustment.
  • Oral contraceptives: may affect insulin sensitivity and glucose control.

Frequently Asked Questions

Insuman Comb 15 is a human insulin indicated to improve glycaemic control in patients with type 1 diabetes mellitus and type 2 diabetes mellitus. It is prescribed when endogenous insulin production is insufficient or when oral antidiabetic agents alone cannot achieve target blood glucose levels.

Insulin human mimics the action of natural pancreatic insulin. It binds to insulin receptors on muscle, fat, and liver cells, activating intracellular pathways that increase glucose uptake, inhibit hepatic glucose production, and promote storage of glucose as glycogen, thereby lowering circulating blood glucose concentrations.

The dose of Insuman Comb 15 is individualized. A qualified prescriber determines the amount, timing, and frequency based on the patient’s age, weight, type of diabetes, current glycaemic control, diet, and concurrent therapies. Patients should follow the prescribing information and adjust only under medical supervision.

Data on insulin human use during pregnancy and lactation are limited. It may be used if the potential benefit to the mother outweighs any possible risk to the fetus or infant. Treatment decisions should be made by a healthcare professional experienced in managing diabetes in pregnant or nursing women.

To order Insuman Comb 15, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India supplies hospitals, pharmacies, and procurement teams worldwide. After verification of trade or institutional credentials, the sales team will provide pricing, availability, shipping details (including cold‑chain logistics if needed), and required import documentation.

Insuman Comb 15 contains human insulin, which has a rapid onset and short duration similar to other short‑acting insulins. Compared with insulin analogues, it may have a slightly slower onset and longer duration, but it remains an effective option for basal‑bolus regimens, especially where cost‑effectiveness is a priority.

Insuman Comb 15 must be stored in a refrigerator at 2‑8 °C (36‑46 °F). Keep the product in its original packaging, protect it from light, and avoid freezing. If refrigeration is unavailable for a short period, it may be kept at room temperature (up to 25 °C) for a maximum of 28 days, after which it should be discarded.

Insuman Comb 15 is administered by subcutaneous injection, typically into the abdomen, thigh, or upper arm. The injection site should be rotated to reduce the risk of lipodystrophy. Patients should be trained on proper injection technique, needle disposal, and timing relative to meals to achieve optimal glucose control.

The most serious risks include severe hypoglycaemia, which can lead to seizures, loss of consciousness, or death, and allergic reactions such as anaphylaxis. Patients should be educated to recognize early signs of low blood sugar and to seek immediate medical attention if a severe reaction occurs.

Insuman Comb 15 should not be used by individuals with a known hypersensitivity to insulin human or any of the product’s excipients. It is also contraindicated in patients experiencing hypoglycaemia until the condition is corrected. Clinicians should evaluate each patient’s medical history before initiating therapy.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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