Product image of Insuman Comb 15 (Insulin Human) supplied by GNH India

Insuman Comb 15

Active Ingredient:
Insulin Human
Origin:
EU

Insuman Comb 15 (Insulin Human)

Insulin Human, the active ingredient in Insuman Comb 15, is an insulin presented as a subcutaneous injectable formulation for subcutaneous use. It is used to control blood glucose levels in patients with type 1 and type 2 diabetes mellitus, providing basal and prandial coverage as part of a comprehensive insulin therapy regimen.

GNH India supplies Insuman Comb 15 as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide. The company adheres to stringent quality standards and provides reliable global distribution.

Manufacturer / TM Owner

Sanofi-Aventis Deutschland Gmbh

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Indications & Clinical Uses

Insuman Comb 15 is an insulin used in the management of diabetes mellitus, targeting glucose regulation.

  • Type 1 diabetes mellitus: provides basal and mealtime insulin to maintain target blood glucose levels.
  • Type 2 diabetes mellitus: supplements endogenous insulin to improve glycemic control when oral agents are insufficient.
  • Gestational diabetes mellitus: replaces or supplements insulin to achieve euglycemia during pregnancy.

How It Works

  • Insulin Human binds to insulin receptors on muscle, adipose and hepatic cells, activating the receptor’s intrinsic tyrosine kinase activity. This triggers intracellular signaling cascades that promote translocation of GLUT‑4 transporters, increase glucose uptake, enhance glycogen synthesis, and suppress hepatic gluconeogenesis, thereby lowering circulating glucose concentrations.

Side Effects

Insuman Comb 15 may cause a range of adverse reactions.

Common Side Effects

  • Hypoglycemia: low blood glucose episodes, especially if dose is excessive.
  • Injection site reactions: redness, swelling, or itching at the injection site.
  • Weight gain: increased adipose tissue due to improved glucose utilization.
  • Lipodystrophy: localized changes in fat tissue with repeated injections.
  • Edema: mild fluid retention, particularly in the lower extremities.

Serious or Rare Side Effects

  • Severe hypoglycemia: can lead to seizures, loss of consciousness, or coma.
  • Allergic reactions: rash, urticaria, or anaphylaxis requiring immediate medical attention.
  • Insulin antibodies: may alter insulin efficacy and cause unpredictable glucose control.
  • Hypokalemia: low serum potassium levels, especially with high insulin doses.

Precautions & Warnings

When using Insuman Comb 15, careful monitoring and patient education are essential.

  • Dose adjustment: tailor the dose based on regular blood glucose monitoring and clinical response.
  • Hypoglycemia risk: educate patients on recognizing and treating low blood glucose promptly.
  • Renal impairment: monitor closely as reduced renal function may prolong insulin action.
  • Pregnancy: use only if the anticipated benefit justifies potential risk to the fetus.
  • Store at 2-8°C: keep refrigerated, protect from light, do not freeze or shake.

Avoid Interactions

Insuman Comb 15 can interact with several medications, affecting glycemic control.

Major Interactions (Avoid)

  • Beta‑blockers: may mask hypoglycemia symptoms, delaying recognition.
  • MAO inhibitors: can potentiate insulin’s glucose‑lowering effect, increasing hypoglycemia risk.
  • Concurrent use of other insulins: additive hypoglycemic effect may occur.
  • Glucocorticoids: may raise blood glucose, necessitating higher insulin doses.

Moderate Interactions (Monitor Closely)

  • Thiazide diuretics: may increase blood glucose levels.
  • Oral contraceptives: can alter insulin requirements during hormonal changes.
  • ACE inhibitors: may enhance insulin sensitivity, requiring dose reassessment.

Frequently Asked Questions

Insuman Comb 15 is a human insulin formulation prescribed to manage blood glucose levels in individuals with type 1 or type 2 diabetes mellitus. It provides both basal and prandial insulin coverage, helping to achieve target glycemic control as part of a comprehensive diabetes treatment plan.

Insulin human mimics the action of natural pancreatic insulin by binding to insulin receptors on muscle, fat, and liver cells. This binding activates signaling pathways that increase glucose uptake, promote glycogen storage, and suppress hepatic glucose production, thereby lowering circulating blood sugar concentrations.

The dose of Insuman Comb 15 is individualized and determined by the prescribing healthcare professional based on factors such as the patient’s blood glucose readings, diet, activity level, and overall treatment goals. Patients should follow the prescriber’s instructions and not adjust the dose without medical guidance.

Insulin is generally considered the treatment of choice for diabetes in pregnancy because it does not cross the placenta in significant amounts. However, the decision to use Insuman Comb 15 during pregnancy or while breastfeeding should be made by a qualified healthcare provider, weighing the benefits against any potential risks.

To order Insuman Comb 15, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies, and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details (including cold‑chain handling if needed), and necessary import documentation.

Insuman Comb 15 contains human insulin, which has a well‑established safety and efficacy profile. Compared with rapid‑acting insulin analogues, it may have a slightly slower onset but offers reliable basal and prandial coverage. Choice of insulin depends on individual patient needs, lifestyle, and physician preference.

Insuman Comb 15 should be stored in a refrigerator at 2‑8 °C, protected from light, and must not be frozen or shaken. Once in use, the vial or pen can be kept at controlled room temperature (up to 30 °C) for a maximum of 28 days, according to the manufacturer’s guidelines.

Insuman Comb 15 is administered by subcutaneous injection into the abdomen, thigh, or upper arm. The injection technique, site rotation, and timing relative to meals should follow the prescribing clinician’s instructions to ensure optimal absorption and glucose control.

The most serious risks include severe hypoglycemia, which can cause seizures, loss of consciousness, or coma, and allergic reactions such as anaphylaxis. Patients should be educated to recognize early signs of low blood sugar and to seek immediate medical attention if a severe reaction occurs.

Insuman Comb 15 is contraindicated in individuals with a known hypersensitivity to human insulin or any of the product’s excipients. It should also be used with caution in patients with severe renal or hepatic impairment, and those who are not able to monitor blood glucose regularly.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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