Product image of Insuman Comb 15 Solostar (Insulin Human) supplied by GNH India

Insuman Comb 15 Solostar

Active Ingredient:
Insulin Human
Origin:
EU

Insuman Comb 15 Solostar (Insulin Human)

Insulin human, the active ingredient in Insuman Comb 15 Solostar, is an insulin presented as a premixed insulin injection for subcutaneous use. It is used to manage blood glucose levels in patients with type 1 and type 2 diabetes mellitus, providing both basal and prandial insulin coverage as prescribed.

GNH India supplies Insuman Comb 15 Solostar as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide. The company adheres to stringent quality standards and provides reliable cold‑chain logistics for biologic products.

Manufacturer / TM Owner

Sanofi-Aventis Deutschland Gmbh

1
Pack/s
This product is added to your enquiry list

Request a Quote

Please fill out the form below and our team will get back to you shortly with pricing and further information.

A minimum order value applies. Our team will confirm the exact amount or quantity after reviewing your requirements.

Indications & Clinical Uses

  • Insuman Comb 15 Solostar is a premixed insulin used to control hyperglycemia in diabetes mellitus.
  • Type 1 diabetes mellitus: provides basal and mealtime insulin to achieve target blood glucose levels.
  • Type 2 diabetes mellitus: improves glycemic control when basal and prandial insulin are required.
  • Mixed‑insulin therapy in diabetes: delivers a fixed ratio of rapid‑acting and intermediate‑acting insulin for convenient dosing.
  • Adjunct to oral antidiabetic agents: can be added when oral therapy no longer maintains glycemic targets.

How It Works

  • Insulin human binds to insulin receptors on cell membranes, activating the intrinsic tyrosine kinase pathway. This triggers downstream signaling that promotes translocation of GLUT‑4 transporters to the cell surface, enhancing glucose uptake in muscle and adipose tissue, while suppressing hepatic gluconeogenesis and glycogenolysis. The premixed formulation combines rapid‑acting and intermediate‑acting insulin components to provide both immediate post‑prandial and sustained basal insulin activity.

Side Effects

Insuman Comb 15 Solostar may be associated with a range of adverse reactions, varying from mild to severe.

Common Side Effects

  • Hypoglycemia.
  • Injection site reactions (pain, redness).
  • Weight gain.

Serious or Rare Side Effects

  • Severe hypoglycemia with loss of consciousness.
  • Anaphylaxis or severe allergic response.
  • Lipodystrophy with lipoatrophy or lipohypertrophy.
  • Diabetic ketoacidosis when insulin is omitted.

Precautions & Warnings

  • When using Insuman Comb 15 Solostar, careful monitoring and patient education are essential.
  • Monitor blood glucose regularly: adjust dose based on readings and meals.
  • Avoid injection during hypoglycemia: do not administer if glucose is low.
  • Check for allergic reactions: discontinue if severe rash or swelling occurs.
  • Use with caution in renal or hepatic impairment: dose may need adjustment.
  • Pregnancy and breastfeeding: only use if benefits outweigh potential risks.
  • Store at 2-8°C: keep refrigerated, protect from light, do not freeze or shake.

Avoid Interactions

Insuman Comb 15 Solostar can interact with several medicines, requiring attention to avoid harmful effects.

Major Interactions (Avoid)

  • Concurrent use of beta‑blockers may mask hypoglycemia symptoms.
  • Alcohol excess can potentiate insulin’s glucose‑lowering effect leading to unpredictable hypoglycemia.
  • Use with MAO inhibitors may increase risk of severe hypoglycemia.

Moderate Interactions (Monitor Closely)

  • Thiazide diuretics may raise blood glucose, requiring dose adjustment.
  • Corticosteroids can increase glucose levels, possibly necessitating higher insulin dose.
  • ACE inhibitors may affect potassium balance but generally do not require insulin dose change.

Frequently Asked Questions

Insuman Comb 15 Solostar is a premixed insulin formulation that provides both rapid‑acting and intermediate‑acting insulin. It is prescribed to help patients with type 1 or type 2 diabetes mellitus achieve better blood‑glucose control by covering basal needs and post‑meal glucose spikes.

Insulin human mimics the natural hormone insulin. It binds to insulin receptors on muscle, fat and liver cells, activating a signaling cascade that moves glucose‑transport proteins to the cell surface, allowing glucose to enter cells for energy. It also suppresses liver production of glucose, lowering overall blood‑sugar levels.

The dose is individualized and set by a qualified prescriber. It is based on factors such as the patient’s current blood‑glucose readings, carbohydrate intake, body weight, renal function, and overall treatment goals. Patients should follow the dosing schedule and adjustments recommended by their healthcare professional.

Safety data are limited. Insulin is generally considered the preferred glucose‑lowering therapy in pregnancy because it does not cross the placenta in harmful amounts. Use during pregnancy or while breastfeeding should only occur when the prescriber judges that the benefits to the mother outweigh any potential risks to the fetus or infant.

To place an order, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, cold‑chain shipping details and any necessary import documentation.

Insuman Comb 15 Solostar contains human insulin in a fixed ratio of rapid‑acting and intermediate‑acting components, similar to other premixed products such as NovoMix 30 or Humalog Mix 25. Compared with analog‑based mixes, human‑insulin mixes may have a slightly different onset and duration, but they all aim to simplify basal‑bolus therapy with fewer daily injections.

The product must be stored refrigerated at 2 °C to 8 °C. Keep it in the original carton to protect from light, do not freeze, and avoid shaking the vial. Once in use, most premixed insulins remain stable for up to 28 days at room temperature, but check the label for the exact in‑use period.

It is given by subcutaneous injection, typically into the abdomen, thigh, or upper arm. The injection site should be rotated to reduce lipodystrophy. Patients should use a sterile needle, follow aseptic technique, and inject the prescribed dose at the times indicated by their healthcare provider, usually before meals and at bedtime.

The most critical risks include severe hypoglycemia, which can cause loss of consciousness or seizures, and allergic reactions ranging from rash to anaphylaxis. Omission of doses in insulin‑dependent patients may lead to diabetic ketoacidosis, a life‑threatening condition requiring immediate medical attention.

Patients with known hypersensitivity to human insulin or any excipients in the formulation should avoid it. It is also contraindicated in individuals experiencing acute hypoglycemia until glucose levels are corrected. Caution is advised for those with severe renal or hepatic impairment, and prescribers should evaluate each case individually.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

Disclaimer

At GNH India, we aim to provide information that is expert-reviewed, accurate, and reliable. However, all content on this platform is intended for general informational purposes only and does not constitute professional medical advice, diagnosis, or treatment. While efforts are made to maintain accuracy and currency, the information may contain errors, omissions, or may not reflect the latest developments. Always consult a qualified healthcare professional regarding any medical concerns.

All product names, brand names, trademarks and registered trademarks displayed on this website are the property of their respective owners. This website and its operator are not affiliated with, endorsed by, or authorized by any such trade mark owners unless expressly stated. Any reference to product names or trademarks is made solely for descriptive and informational purposes. No commercial relationship, sponsorship, approval, or association with any trademark owner should be inferred. Information provided herein does not constitute promotion, advertising, or an offer for sale of any medicinal product and is intended solely for general informational purposes.

All trademarks and brand names displayed on this website are used strictly in accordance with the provisions of the Trade Marks Act, 1999, specifically Sections 30 and 30(1) governing fair use. Trademark ownership has been accurately attributed under the "Manufacturer/ TM Owner" section in compliance with statutory requirements.

Ordering Process

Simple, Secure, and Seamless

Learn how our streamlined ordering process guarantees fast, compliant, and reliable access to essential medicines worldwide.

Quote request form

01

Submit Quote Request Form

Tell us what medications you need by filling out our simple form and uploading a valid document.

Price estimate review

02

We Review & Send Estimate

Our licensed pharmacists will verify your details and provide you with a detailed cost estimate.

Secure payment

03

Confirm & Make Payment

Discuss any queries, approve the estimate, and complete your payment.

Worldwide delivery

04

Get Delivered

Your medicines, safely packed and delivered to your door or nearest airport — hassle-free.

Quality You Can Trust

Our internationally recognized certifications underscore our commitment to safety, quality, and excellence.