Product image of Insuman Comb 25 (Insulin Human) supplied by GNH India

Insuman Comb 25

Active Ingredient:
Insulin Human
Origin:
EU

Insuman Comb 25 (Insulin Human)

Insulin Human, the active ingredient in Insuman Comb 25, is an insulin presented as a subcutaneous injectable for diabetes management. It is used to control blood glucose levels in patients with insulin‑dependent diabetes.\nGNH India supplies Insuman Comb 25 as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Sanofi-Aventis Deutschland Gmbh

1
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Indications & Clinical Uses

  • Insuman Comb 25 is an insulin analogue that acts on the glucose regulation pathway to manage hyperglycaemia in diabetes.\n\n- Type 1 diabetes mellitus: provides basal and prandial insulin coverage to replace the absent endogenous insulin, helping maintain target glycaemic ranges.\n- Type 2 diabetes mellitus: supplements endogenous insulin production and improves post‑prandial glucose control when oral agents are insufficient.

How It Works

  • Insulin Human binds to insulin receptors on muscle, adipose and hepatic cells, activating the receptor’s intrinsic tyrosine kinase activity. This triggers downstream signaling that promotes glucose uptake, glycogen synthesis, and lipogenesis while suppressing hepatic gluconeogenesis, thereby lowering circulating blood glucose concentrations.

Side Effects

  • Insuman Comb 25 may be associated with a range of adverse reactions.\n\nCommon Side Effects:\n- Hypoglycaemia: low blood glucose episodes, especially if meals are missed or dosing is excessive.\n- Injection‑site reactions: redness, swelling, or bruising at the injection site.\n- Weight gain: modest increase due to improved glucose utilisation.\n- Lipodystrophy: localized fat accumulation or loss with repeated injections.\n- Edema: mild peripheral swelling, particularly in the lower limbs.\n\nSerious or Rare Side Effects:\n- Severe hypoglycaemia leading to seizures or loss of consciousness.\n- Anaphylactic reaction: urticaria, bronchospasm, or angio‑edema requiring emergency care.\n- Hypokalemia: low serum potassium levels, especially with high insulin doses.\n- Insulin allergy: systemic hypersensitivity manifesting as fever, rash, or organ involvement.

Precautions & Warnings

  • When using Insuman Comb 25, clinicians and patients should observe several safety measures.\n\n- Dose adjustment: tailor the insulin dose to individual glucose monitoring results and lifestyle factors.\n- Blood‑glucose monitoring: perform frequent self‑monitoring to detect hypoglycaemia early.\n- Renal impairment: reduce dose cautiously as reduced clearance can increase hypoglycaemia risk.\n- Pregnancy and lactation: use only if clearly needed; benefits must outweigh potential risks.\n- Store at 2-8°C: keep refrigerated, protect from light, do not freeze or shake the vial.

Avoid Interactions

  • Insuman Comb 25 can interact with several drug classes, influencing glucose control or insulin action.\n\nMajor Interactions (Avoid):\n- Concurrent sulfonylureas or meglitinides: may cause severe hypoglycaemia.\n- Beta‑blockers: can mask typical hypoglycaemia symptoms such as tachycardia.\n\nModerate Interactions (Monitor Closely):\n- ACE inhibitors or ARBs: may potentiate insulin’s glucose‑lowering effect.\n- Thiazide diuretics: can raise blood glucose, requiring dose reassessment.\n- Oral contraceptives: may alter insulin requirements during hormonal changes.

Frequently Asked Questions

Insuman Comb 25 is a human insulin formulation used to control blood glucose levels in patients with Type 1 or Type 2 diabetes mellitus. It provides both basal and prandial insulin activity, helping achieve target glycaemic control as part of a comprehensive diabetes management plan.

Insulin Human mimics the action of natural pancreatic insulin. It binds to insulin receptors on muscle, fat, and liver cells, activating intracellular pathways that increase glucose uptake, promote glycogen storage, and suppress hepatic glucose production, thereby lowering circulating blood sugar.

The dose of Insuman Comb 25 is individualized. A qualified prescriber determines the appropriate amount based on the patient’s blood‑glucose readings, diet, activity level, and overall treatment goals. Patients should follow the prescribing clinician’s instructions and adjust only under medical supervision.

Insulin is generally considered the preferred glucose‑lowering therapy during pregnancy because it does not cross the placenta. However, the safety of Insuman Comb 25 specifically has not been fully established, so it should be used only when clearly needed and under close medical supervision.

To request Insuman Comb 25, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details (including cold‑chain if required) and import documentation.

Insuman Comb 25 contains human insulin, whereas many newer products use insulin analogues with altered absorption profiles. Human insulin provides reliable glucose‑lowering effects but may have a shorter onset and duration compared with rapid‑acting or long‑acting analogues, influencing dosing frequency and flexibility.

Insuman Comb 25 should be stored in a refrigerator at 2‑8 °C, protected from light. Do not freeze or shake the vial. Once in use, it may be kept at room temperature (up to 30 °C) for a limited period, typically 28 days, as indicated on the label.

Insuman Comb 25 is given by subcutaneous injection, usually into the abdomen, thigh, or upper arm. The injection site should be rotated to reduce lipodystrophy. Patients should be trained on proper technique, needle selection, and disposal of sharps according to local regulations.

The most serious risks include severe hypoglycaemia, which can lead to seizures or loss of consciousness, and rare allergic reactions such as anaphylaxis. Prompt recognition of symptoms and immediate medical attention are essential to mitigate these potentially life‑threatening events.

Insuman Comb 25 is contraindicated in individuals with a known hypersensitivity to human insulin or any excipients in the formulation. Patients with recurrent severe hypoglycaemia despite dose adjustments, or those who cannot reliably monitor blood glucose, should discuss alternative therapies with their clinician.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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