Product image of Insuman Comb 25 (Insulin Human) supplied by GNH India

Insuman Comb 25

Active Ingredient:
Insulin Human
Origin:
EU

Insuman Comb 25 (Insulin Human)

Insulin Human, the active ingredient in Insuman Comb 25, is an insulin presented as a premixed injectable solution for subcutaneous use. It treats diabetes mellitus in both type 1 and type 2 patients, providing basal and prandial glucose control.

GNH India supplies Insuman Comb 25 as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Sanofi-Aventis Deutschland Gmbh

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Indications & Clinical Uses

Insuman Comb 25 is an insulin preparation used to manage hyperglycaemia in diabetes mellitus.

  • Type 1 diabetes mellitus: provides both basal and mealtime insulin to maintain target blood‑glucose levels.
  • Type 2 diabetes mellitus: complements oral agents or other insulins when additional glucose control is required.
  • Insulin deficiency states (e.g., post‑pancreatectomy): replaces absent endogenous insulin to prevent hyperglycaemia.

How It Works

  • Insulin Human binds to insulin receptors on muscle, adipose and hepatic cells, activating the receptor’s tyrosine kinase activity. This triggers intracellular signaling that promotes glucose uptake via GLUT‑4 translocation, suppresses hepatic gluconeogenesis, and enhances glycogen synthesis, thereby lowering circulating blood‑glucose concentrations.

Side Effects

Common Side Effects

  • Hypoglycaemia: low blood‑glucose episodes, especially if meals are missed or dosing is excessive.
  • Injection‑site reactions: redness, swelling, or itching at the injection site.
  • Weight gain: due to improved glucose utilisation and storage.
  • Lipodystrophy: localized fat accumulation or loss at injection sites.
  • Edema: mild peripheral fluid retention.

Serious or Rare Side Effects

  • Severe hypoglycaemia with seizures or loss of consciousness.
  • Allergic reactions including anaphylaxis or urticaria.
  • Insulin antibody formation leading to unpredictable glucose control.
  • Lipohypertrophy causing painful nodules.
  • Acute metabolic acidosis in rare cases.

Precautions & Warnings

Insuman Comb 25 requires careful monitoring and patient education.

  • Renal impairment: adjust dose and monitor glucose closely.
  • Hepatic dysfunction: consider more frequent glucose checks.
  • Pregnancy: use only if benefits outweigh risks and under medical supervision.
  • Concomitant beta‑blockers: may mask hypoglycaemia symptoms.
  • Do not mix with other insulin formulations in the same syringe.
  • Store at 2-8°C: keep refrigerated, protect from light, do not freeze or shake.

Avoid Interactions

Insuman Comb 25 may interact with several drug classes.

Major Interactions (Avoid)

  • Sulfonylureas or meglitinides: additive risk of severe hypoglycaemia.
  • Beta‑blockers: can mask hypoglycaemia warning signs.
  • Corticosteroids: may increase glucose levels, requiring dose adjustment.

Moderate Interactions (Monitor Closely)

  • Thiazide diuretics: may raise blood‑glucose modestly.
  • ACE inhibitors: may enhance insulin sensitivity, necessitating monitoring.
  • Oral contraceptives: may slightly affect insulin requirements.

Frequently Asked Questions

Insuman Comb 25 is a premixed insulin formulation used to control blood‑glucose levels in patients with type 1 or type 2 diabetes mellitus, as well as in other insulin‑deficient conditions where basal and prandial insulin coverage is needed.

Insulin Human binds to insulin receptors on muscle, fat and liver cells, activating signaling pathways that increase glucose uptake, suppress hepatic glucose production, and promote glycogen synthesis, thereby reducing circulating blood‑glucose concentrations.

The dose of Insuman Comb 25 is individualized. A qualified prescriber determines the appropriate amount based on the patient’s age, weight, glycaemic targets, current therapy and response to treatment.

Insuman Comb 25 should be used in pregnancy or while breastfeeding only if the prescriber judges that the benefit to the mother outweighs any potential risk to the fetus or infant. Close monitoring of blood‑glucose is essential.

To order, submit an enquiry on the product page at gnhindia.com specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details (including cold‑chain where required) and import documentation.

Insuman Comb 25 is a premixed insulin containing both rapid‑acting and intermediate‑acting components, offering convenience compared with separate basal and bolus injections. It differs from basal‑only insulins (e.g., glargine) and rapid‑acting analogues (e.g., lispro) in its pharmacokinetic profile and dosing schedule.

Store the product at 2‑8 °C (refrigerated), protected from light. Do not freeze or shake the vial. Once opened, it may be kept at room temperature for a limited period as indicated in the product label, but should be discarded after the recommended in‑use time.

Insuman Comb 25 is administered by subcutaneous injection, typically into the abdomen, thigh or upper arm. The injection site should be rotated to reduce the risk of lipodystrophy, and the dose is injected using a sterile needle according to the prescriber’s instructions.

The most serious risks include severe hypoglycaemia, which can lead to seizures or loss of consciousness, and allergic reactions such as anaphylaxis. Patients should be educated to recognize early signs of hypoglycaemia and to seek immediate medical attention for any severe allergic response.

Insuman Comb 25 is contraindicated in individuals with a known hypersensitivity to human insulin or any excipients in the formulation. It should also be avoided in patients experiencing hypoglycaemia until glucose levels are corrected.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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