Product image of Insuman Comb 25 (Insulin Human) supplied by GNH India

Insuman Comb 25

Active Ingredient:
Insulin Human
Origin:
EU

Insuman Comb 25 (Insulin Human)

Insulin human, the active ingredient in Insuman Comb 25, is a insulin presented as a subcutaneous injectable for diabetes management. It is used to lower blood glucose in patients with type 1 and type 2 diabetes mellitus.\n\nGNH India supplies Insuman Comb 25 as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Sanofi-Aventis Deutschland Gmbh

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Indications & Clinical Uses

  • Insuman Comb 25 is an insulin preparation indicated for the treatment of diabetes mellitus.\n\n- Type 1 diabetes mellitus: provides basal and prandial insulin coverage to achieve target glycaemic control.\n- Type 2 diabetes mellitus: improves glycaemic control when oral agents are insufficient or when insulin therapy is required.

How It Works

  • Insulin human binds to insulin receptors on peripheral tissues, activating the receptor’s tyrosine kinase activity. This triggers intracellular signaling that promotes glucose transporter (GLUT4) translocation, increasing glucose uptake in muscle and adipose tissue, while simultaneously suppressing hepatic gluconeogenesis and glycogenolysis, thereby lowering plasma glucose levels.

Side Effects

  • Common Side Effects:\n- Hypoglycaemia: low blood glucose episodes, especially if meals are missed or dose is excessive.\n- Injection‑site reactions: redness, swelling, or itching at the injection site.\n- Weight gain: increased caloric storage associated with improved glucose utilisation.\n- Lipodystrophy: localized thickening or atrophy of subcutaneous fat with repeated injections.\n- Edema: mild fluid retention, particularly in the lower extremities.\n- Localised allergic reactions: mild rash or urticaria at the site.\n\nSerious or Rare Side Effects:\n- Severe hypoglycaemia: prolonged loss of consciousness or seizures requiring emergency care.\n- Anaphylactic reaction: systemic allergic response that can be life‑threatening.\n- Insulin antibody formation: may alter insulin effectiveness and cause unpredictable glucose control.\n- Hypokalemia: low serum potassium secondary to rapid glucose shift into cells.

Precautions & Warnings

  • Patients receiving Insuman Comb 25 should be monitored closely for glycaemic trends and dose adjustments.\n\n- Monitor blood glucose regularly: adjust dose based on fasting and post‑prandial readings.\n- Adjust dose during illness or stress: hyperglycaemia may require temporary dose increase.\n- Avoid use in patients with hypoglycaemia unawareness without proper education.\n- Use caution in renal or hepatic impairment: insulin clearance may be reduced.\n- Store at 2-8°C: keep refrigerated, protect from light, do not freeze or shake.

Avoid Interactions

  • Insuman Comb 25 may interact with several drug classes that affect glucose homeostasis.\n\nMajor Interactions (Avoid):\n- Sulfonylureas: additive risk of severe hypoglycaemia.\n- Beta‑blockers: can mask hypoglycaemia symptoms.\n- MAO inhibitors: may potentiate insulin’s glucose‑lowering effect.\n\nModerate Interactions (Monitor Closely):\n- ACE inhibitors: may enhance insulin sensitivity, requiring dose review.\n- Thiazide diuretics: can increase blood glucose, necessitating closer monitoring.\n- Oral contraceptives: may alter glucose control, prompting dose adjustments.

Frequently Asked Questions

Insuman Comb 25 is used to control blood glucose levels in patients with Type 1 and Type 2 diabetes mellitus. It provides both basal and prandial insulin activity, helping achieve target glycaemic control as part of a comprehensive diabetes management plan.

Insulin human binds to insulin receptors on muscle, fat and liver cells, activating intracellular pathways that increase glucose uptake and storage while suppressing hepatic glucose production. This combined action lowers circulating glucose and restores normal metabolic balance.

The dose of Insuman Comb 25 is individualized. A qualified prescriber determines the amount based on the patient’s blood‑glucose readings, body weight, diet, activity level and response to therapy. Dosage adjustments are made during follow‑up visits to maintain optimal control.

Insulin is the preferred glucose‑lowering agent during pregnancy because it does not cross the placenta. Insuman Comb 25 may be used under medical supervision in pregnant or lactating women, but the prescriber should weigh benefits against any potential risks.

To order, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details (including cold‑chain if needed) and import documentation.

Insuman Comb 25 contains human insulin, which has a slower onset and longer duration than rapid‑acting analogues such as insulin lispro or aspart. It is often used when a more gradual insulin profile is desired, whereas rapid‑acting analogues are preferred for mealtime spikes due to their quicker action.

Store Insuman Comb 25 refrigerated between 2 °C and 8 °C. Protect the vial from light, do not freeze, and avoid shaking. Once in use, it may be kept at controlled room temperature (up to 25 °C) for a limited period as indicated on the label.

Insuman Comb 25 is given by subcutaneous injection, typically into the abdomen, thigh or upper arm. Use a sterile needle or an appropriate insulin pen, rotate injection sites to reduce lipodystrophy, and follow the prescriber’s instructions for timing relative to meals.

The most serious risks include severe hypoglycaemia, which can cause loss of consciousness or seizures, and systemic allergic reactions such as anaphylaxis. Patients should be educated to recognize early signs and have emergency glucose sources available.

Insuman Comb 25 should not be used by individuals with a known hypersensitivity to human insulin or any excipients in the formulation. It is also contraindicated in patients with severe hypoglycaemia unawareness who cannot reliably monitor or respond to low glucose episodes.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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