Product image of Insuman Comb 25 Solostar (Insulin Human (Rdna)) supplied by GNH India

Insuman Comb 25 Solostar

Active Ingredient:
Insulin Human (Rdna)
Origin:
EU

Insuman Comb 25 Solostar (Insulin Human (Rdna))

Insulin Human, the active ingredient in Insuman Comb 25 Solostar, is an insulin presented as a premixed insulin solution for subcutaneous injection use. It treats diabetes mellitus in both type 1 and type 2 patients by providing basal and rapid‑acting glucose control.

GNH India supplies Insuman Comb 25 Solostar as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Sanofi-Aventis Deutschland Gmbh

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Indications & Clinical Uses

Insuman Comb 25 Solostar, a premixed human insulin, is used to manage blood glucose in diabetes mellitus.

  • Type 1 diabetes mellitus: provides basal and prandial insulin to control fasting and post‑meal glucose levels.
  • Type 2 diabetes mellitus: adds insulin coverage when oral agents are insufficient, offering combined basal and rapid‑acting action.
  • Insulin‑deficient hyperglycemia: reduces elevated blood glucose during acute illness or stress in patients lacking adequate endogenous insulin.

How It Works

  • Insulin Human binds to insulin receptors on muscle, adipose and hepatic cells, activating the receptor’s tyrosine kinase activity. This triggers intracellular signaling that promotes glucose uptake, glycogen synthesis, and inhibition of hepatic glucose production, thereby lowering circulating blood glucose concentrations.

Side Effects

Insuman Comb 25 Solostar may cause a range of adverse reactions.

Common Side Effects

  • Hypoglycemia: low blood sugar episodes, especially if meals are missed or dosing is excessive.
  • Injection site pain or erythema: mild discomfort or redness at the injection site.
  • Weight gain: increase in body weight due to improved glucose utilization.
  • Lipodystrophy: localized changes in fat tissue at injection sites.

Serious or Rare Side Effects

  • Severe hypoglycemia: profound low blood sugar that can lead to seizures or loss of consciousness.
  • Anaphylactic reaction: rare systemic allergic response requiring immediate medical attention.
  • Insulin antibody formation: immune response that may alter insulin effectiveness.

Precautions & Warnings

When using Insuman Comb 25 Solostar, several safety considerations are recommended.

  • Blood glucose monitoring: check levels regularly to adjust dose and avoid hypoglycemia.
  • Dose adjustment during illness: increase monitoring and possibly dose when infection or stress raises glucose.
  • Avoid use in active hypoglycemia: do not administer if the patient is already experiencing low blood sugar.
  • Renal impairment caution: reduced clearance may require dose modification.
  • Pregnancy and lactation: safety data are limited; use only if benefits outweigh risks.
  • Store at 2-8°C: keep refrigerated, protect from light, do not freeze or shake the pen.

Avoid Interactions

Insuman Comb 25 Solostar can interact with other medications, affecting glucose control.

Major Interactions (Avoid)

  • Sulfonylureas: combined effect may cause severe hypoglycemia.
  • Meglitinides: additive glucose‑lowering effect increases hypoglycemia risk.
  • GLP‑1 receptor agonists: potentiate insulin action, heightening hypoglycemia potential.

Moderate Interactions (Monitor Closely)

  • Corticosteroids: may raise blood glucose, requiring dose adjustments.
  • Thiazide diuretics: can increase glucose levels, necessitating closer monitoring.
  • ACE inhibitors: may enhance insulin sensitivity, potentially leading to lower glucose readings.

Frequently Asked Questions

Insuman Comb 25 Solostar is a premixed human insulin indicated for the management of blood glucose in patients with type 1 and type 2 diabetes mellitus. It delivers both basal and rapid‑acting insulin components to help control fasting and post‑prandial glucose levels as part of a comprehensive diabetes treatment plan.

Insulin Human mimics the action of naturally produced insulin by binding to insulin receptors on muscle, fat and liver cells. This binding activates intracellular pathways that increase glucose uptake, stimulate glycogen synthesis, and suppress hepatic glucose output, thereby lowering circulating blood glucose concentrations.

The dosage of Insuman Comb 25 Solostar is individualized. A qualified prescriber determines the appropriate amount based on the patient’s age, weight, type of diabetes, current glycemic control, diet, and other medications. Patients should follow the prescribing healthcare professional’s instructions and not adjust the dose on their own.

Safety data for Insuman Comb 25 Solostar in pregnancy and lactation are limited, and the product’s pregnancy category is unknown. It should only be used if the potential benefits to the mother outweigh any possible risks to the fetus or infant, and under close medical supervision.

To place an order, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India supplies hospitals, pharmacies and procurement teams worldwide. After receiving the request, the sales team will verify trade or institutional credentials, then provide pricing, availability, shipping details (including cold‑chain logistics if needed) and any required import documentation.

Insuman Comb 25 Solostar is a premixed human insulin containing a fixed ratio of intermediate‑acting and rapid‑acting components. Compared with basal‑only insulins, it offers both background and mealtime coverage in a single injection, reducing the number of daily shots. Unlike some analog insulins, it uses recombinant human insulin, which may be preferred for patients seeking a biosimilar option.

The pen should be stored at 2‑8 °C (refrigerated) and protected from light. Do not freeze or shake the device. Once in use, it may be kept at room temperature (up to 30 °C) for a maximum of 28 days, as indicated on the label. Always keep the pen in its original packaging to maintain sterility.

Insuman Comb 25 Solostar is delivered subcutaneously using the pre‑filled pen. The injection site should be rotated among the abdomen, thigh or upper arm to reduce lipodystrophy. Patients should clean the skin with an alcohol swab, attach a new needle, set the prescribed dose, and inject at a 90‑degree angle. Proper technique should be taught by a healthcare professional.

The most serious risks include severe hypoglycemia, which can cause seizures, loss of consciousness or injury, and rare allergic reactions such as anaphylaxis. Patients should be educated to recognize early signs of low blood sugar and to seek immediate medical help if an allergic response occurs.

Insuman Comb 25 Solostar should be avoided in individuals with known hypersensitivity to human insulin or any excipients in the formulation. It is also contraindicated in patients experiencing active hypoglycemia. Caution is advised for those with severe renal or hepatic impairment, and the product should be used only under medical supervision in such cases.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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